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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063352
UUCD1 version UUC-MuM-00750
Ensembl Protein ID ENSMUSP00000043780.4
UniProt Accession Q8CIK8; Q3UV90; Q6PJA8; Q8R2T9; Q8R351; RFWD3_MOUSE
Genbank Protein ID BAE23381.1; BAE23467.1; AAH18533.2; AAH23694.1; AAH26603.1; AAH27246.1; AAH96602.1
Protein Name E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3
Genbank Nucleotide ID AK137499; AK137698; BC018533; BC023694; BC026603; BC027246; BC096602
Gene Name Rfwd3; Rnf201
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033596.5 ENSMUST00000038739.4 ENSMUSP00000043780.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-06 28.4 496 534
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+  +++l+f  ++ +ll+s+s D+tik+ +l t+++++
   Q: 496  HNKQIRGLSFssQSkGLLLSASLDCTIKLTSLETNTVVQ 534
           9999*******8556*************98888877766 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair (By similarity).
 E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair (By similarity).
Protein Sequence
(Fasta)
MAEVAVGQAS DLVPSEMDHE VIYSHLQGPL EGTIEPATPT EVVSNGAPLQ PAPAELANSQ 60
GGAHVQPAPA EVVSSQDGLP TLQPLPPASI DLTEEVQPSE ENMEVVNPGT SEEPSQGSGA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063352|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
GCGCGGGCGG AGCGGGTGCG CAGTAGGGGA TGCGCGGTAA CGATGGCCGA AGTCGCGGTC 60
GGCCAGGCGT CCGACTTGGT CCCCTCAGGT GAGGCTGCTC CCTGCTTCTT CTCCGCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063352|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0035861--C:site of double-strand break
GO:0097371--F:MDM2/MDM4 family protein binding
GO:0002039--F:p53 binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0016567--P:protein ubiquitination
GO:2000001--P:regulation of DNA damage checkpoint
GO:0010212--P:response to ionizing radiation
KEGG mmu:234736
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000929 Aegilops tauschii 22.66 2.00e-17 83.60
IUUC-Aml-001188 Ailuropoda melanoleuca 64.71 0.00e+00 985.00
IUUC-Atr-003034 Amborella trichopoda 25.72 9.00e-13 67.40
IUUC-Apl-003182 Anas platyrhynchos 65.69 0.00e+00 676.00
IUUC-Aca-004619 Anolis carolinensis 65.24 0.00e+00 707.00
IUUC-Aly-006391 Arabidopsis lyrata 30.87 3.00e-32 133.00
IUUC-Ath-007300 Arabidopsis thaliana 29.75 1.00e-29 125.00
IUUC-Ame-010890 Astyanax mexicanus 58.22 4.00e-176 611.00
IUUC-Bta-013051 Bos taurus 62.40 0.00e+00 921.00
IUUC-Bdi-014519 Brachypodium distachyon 24.37 7.00e-19 89.00
IUUC-Bol-015271 Brassica oleracea 28.33 2.00e-30 127.00
IUUC-Bra-017931 Brassica rapa 31.72 2.00e-30 127.00
IUUC-Cja-019240 Callithrix jacchus 68.58 0.00e+00 955.00
IUUC-Cfa-021010 Canis familiaris 68.17 0.00e+00 986.00
IUUC-Cpo-022308 Cavia porcellus 67.36 0.00e+00 908.00
IUUC-Csa-023501 Chlorocebus sabaeus 68.12 0.00e+00 994.00
IUUC-Cho-024900 Choloepus hoffmanni 63.45 0.00e+00 858.00
IUUC-Cin-025403 Ciona intestinalis 36.71 6.00e-89 322.00
IUUC-Csv-025819 Ciona savignyi 38.37 1.00e-42 166.00
IUUC-Cme-027123 Cyanidioschyzon merolae 25.79 3.00e-18 87.00
IUUC-Dre-028354 Danio rerio 55.51 1.00e-163 570.00
IUUC-Dno-029400 Dasypus novemcinctus 66.80 0.00e+00 930.00
IUUC-Dor-030320 Dipodomys ordii 66.22 0.00e+00 771.00
IUUC-Dme-031949 Drosophila melanogaster 28.05 2.00e-45 176.00
IUUC-Ete-032691 Echinops telfairi 53.37 3.00e-126 446.00
IUUC-Eca-034320 Equus caballus 69.03 0.00e+00 1025.00
IUUC-Fca-035732 Felis catus 69.36 0.00e+00 970.00
IUUC-Fal-036648 Ficedula albicollis 65.49 0.00e+00 674.00
IUUC-Gmo-038609 Gadus morhua 53.46 8.00e-129 453.00
IUUC-Gga-040522 Gallus gallus 64.62 4.00e-99 355.00
IUUC-Gac-042318 Gasterosteus aculeatus 52.05 2.00e-123 435.00
IUUC-Gma-043184 Glycine max 41.46 2.00e-16 80.90
IUUC-Ggo-044464 Gorilla gorilla 68.31 0.00e+00 983.00
IUUC-Hsa-045991 Homo sapiens 68.05 0.00e+00 977.00
IUUC-Hvu-047705 Hordeum vulgare 23.99 1.00e-24 108.00
IUUC-Itr-047977 Ictidomys tridecemlineatus 69.59 0.00e+00 1021.00
IUUC-Lch-050112 Latimeria chalumnae 63.60 0.00e+00 642.00
IUUC-Lpe-051605 Leersia perrieri 24.84 7.00e-15 75.90
IUUC-Loc-052241 Lepisosteus oculatus 59.03 8.00e-176 610.00
IUUC-Laf-054559 Loxodonta africana 68.15 0.00e+00 882.00
IUUC-Mcc-055093 Macaca mulatta 68.38 0.00e+00 984.00
IUUC-Meu-056417 Macropus eugenii 61.42 0.00e+00 642.00
IUUC-Mtr-058533 Medicago truncatula 26.01 1.00e-28 121.00
IUUC-Mga-059498 Meleagris gallopavo 64.06 0.00e+00 656.00
IUUC-Mmr-061782 Microcebus murinus 66.04 0.00e+00 961.00
IUUC-Mdo-062053 Monodelphis domestica 68.02 0.00e+00 718.00
IUUC-Mac-064582 Musa acuminata 25.50 5.00e-20 92.80
IUUC-Mpu-066087 Mustela putorius furo 67.27 0.00e+00 968.00
IUUC-Mlu-068147 Myotis lucifugus 64.65 0.00e+00 910.00
IUUC-Nle-069503 Nomascus leucogenys 65.04 0.00e+00 916.00
IUUC-Opr-070479 Ochotona princeps 60.05 0.00e+00 836.00
IUUC-Ont-071700 Oreochromis niloticus 54.47 1.00e-161 563.00
IUUC-Oan-073702 Ornithorhynchus anatinus 70.04 0.00e+00 745.00
IUUC-Ocu-074886 Oryctolagus cuniculus 64.79 0.00e+00 944.00
IUUC-Oba-075729 Oryza barthii 23.71 8.00e-22 98.60
IUUC-Obr-076562 Oryza brachyantha 26.43 1.00e-19 91.30
IUUC-Ogl-077615 Oryza glaberrima 23.71 8.00e-22 98.60
IUUC-Ogu-078921 Oryza glumaepatula 23.00 3.00e-22 100.00
IUUC-Oin-079250 Oryza indica 25.57 2.00e-15 77.40
IUUC-Olo-080758 Oryza longistaminata 22.50 3.00e-19 90.10
IUUC-Ome-081707 Oryza meridionalis 25.79 3.00e-17 83.20
IUUC-Oni-083006 Oryza nivara 24.09 4.00e-22 99.80
IUUC-Opu-083650 Oryza punctata 26.56 3.00e-22 100.00
IUUC-Oru-084924 Oryza rufipogon 22.84 2.00e-22 100.00
IUUC-Osa-085820 Oryza sativa 23.00 7.00e-22 99.00
IUUC-Ola-087229 Oryzias latipes 54.65 7.00e-129 453.00
IUUC-Oga-088243 Otolemur garnettii 68.76 0.00e+00 954.00
IUUC-Oar-089461 Ovis aries 65.69 0.00e+00 977.00
IUUC-Ptr-090527 Pan troglodytes 68.01 0.00e+00 970.00
IUUC-Pan-092431 Papio anubis 67.72 0.00e+00 914.00
IUUC-Psi-093156 Pelodiscus sinensis 52.46 0.00e+00 731.00
IUUC-Ppa-095305 Physcomitrella patens 44.04 4.00e-20 94.00
IUUC-Pfo-097065 Poecilia formosa 55.49 3.00e-159 555.00
IUUC-Pab-098272 Pongo abelii 67.87 0.00e+00 986.00
IUUC-Pop-099827 Populus trichocarpa 26.91 3.00e-33 137.00
IUUC-Pca-100713 Procavia capensis 58.98 0.00e+00 817.00
IUUC-Ppe-102103 Prunus persica 26.30 6.00e-32 132.00
IUUC-Pva-103133 Pteropus vampyrus 77.18 0.00e+00 683.00
IUUC-Sha-107628 Sarcophilus harrisii 54.89 0.00e+00 758.00
IUUC-Smo-108927 Selaginella moellendorffii 34.69 3.00e-06 46.20
IUUC-Sit-109891 Setaria italica 22.89 1.00e-23 104.00
IUUC-Sly-111779 Solanum lycopersicum 30.62 3.00e-29 123.00
IUUC-Stu-112817 Solanum tuberosum 50.00 2.00e-19 89.00
IUUC-Sar-113124 Sorex araneus 56.85 3.00e-174 605.00
IUUC-Sbi-114107 Sorghum bicolor 24.13 3.00e-26 113.00
IUUC-Ssc-115850 Sus scrofa 67.10 0.00e+00 974.00
IUUC-Tgu-117295 Taeniopygia guttata 66.53 0.00e+00 685.00
IUUC-Tru-117539 Takifugu rubripes 53.88 2.00e-159 555.00
IUUC-Tsy-118805 Tarsius syrichta 62.59 5.00e-100 358.00
IUUC-Tni-120274 Tetraodon nigroviridis 56.16 3.00e-160 558.00
IUUC-Tca-121162 Theobroma cacao 27.30 1.00e-27 118.00
IUUC-Tae-124822 Triticum aestivum 23.75 8.00e-24 105.00
IUUC-Tur-126768 Triticum urartu 33.64 8.00e-16 78.60
IUUC-Tbe-127884 Tupaia belangeri 64.25 1.00e-70 261.00
IUUC-Ttr-128665 Tursiops truncatus 82.47 3.00e-128 452.00
IUUC-Vpa-130385 Vicugna pacos 67.96 0.00e+00 982.00
IUUC-Vvi-131464 Vitis vinifera 26.84 1.00e-25 111.00
IUUC-Xtr-132015 Xenopus tropicalis 65.73 0.00e+00 675.00
IUUC-Xma-133109 Xiphophorus maculatus 56.20 1.00e-160 560.00
Created Date 25-Jun-2017

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