iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036384

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02073577

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000008280.3	ENSFCAT00000008282.3	ENSFCAP00000007676.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-135	449.6	993	1322

Active Site

Position(s)	Description	Evidence
1292	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 993  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1079
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1080 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKIGGSEIVVTNKNKKEYIYLV 1161
           ***********************************99...6666..79*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++
   Q: 1162 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRL 1248
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1249 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1322
           *************************************************************************8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDNN VHMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIQENVKSQE RSSVPSPENV NKKSSCLQIS LQPTRYSGCL QSSNVLADGD DASFMCVLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA TCCTTTGTCA 60
GAGACCTCCG GAGATGATCT GGATAACAAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	94.42	0.00e+00	2449.00
IUUC-Apl-003886	Anas platyrhynchos	76.01	0.00e+00	1268.00
IUUC-Acl-008273	Aspergillus clavatus	48.47	4.00e-158	551.00
IUUC-Afl-008713	Aspergillus flavus	47.97	4.00e-156	545.00
IUUC-Afu-009103	Aspergillus fumigatus	48.48	1.00e-158	553.00
IUUC-Ani-009259	Aspergillus nidulans	47.45	1.00e-157	550.00
IUUC-Ang-009738	Aspergillus niger	47.56	6.00e-155	541.00
IUUC-Aor-010053	Aspergillus oryzae	56.04	2.00e-98	351.00
IUUC-Ate-010529	Aspergillus terreus	48.39	2.00e-157	549.00
IUUC-Ame-011138	Astyanax mexicanus	83.61	0.00e+00	847.00
IUUC-Bgr-012148	Blumeria graminis	46.53	2.00e-153	536.00
IUUC-Bta-012453	Bos taurus	90.82	0.00e+00	2312.00
IUUC-Bci-013785	Botrytis cinerea	47.26	5.00e-157	548.00
IUUC-Cel-018564	Caenorhabditis elegans	54.04	1.00e-180	626.00
IUUC-Cja-019034	Callithrix jacchus	92.67	0.00e+00	1413.00
IUUC-Cfa-020258	Canis familiaris	94.72	0.00e+00	2369.00
IUUC-Cpo-021648	Cavia porcellus	89.19	0.00e+00	1459.00
IUUC-Csa-023334	Chlorocebus sabaeus	94.66	0.00e+00	1497.00
IUUC-Cho-024672	Choloepus hoffmanni	83.08	0.00e+00	711.00
IUUC-Cin-025157	Ciona intestinalis	52.04	0.00e+00	874.00
IUUC-Csv-026098	Ciona savignyi	68.60	0.00e+00	644.00
IUUC-Dno-029159	Dasypus novemcinctus	89.71	0.00e+00	1334.00
IUUC-Dor-030729	Dipodomys ordii	78.14	0.00e+00	1040.00
IUUC-Dse-031241	Dothistroma septosporum	47.57	2.00e-156	546.00
IUUC-Dme-032166	Drosophila melanogaster	67.71	0.00e+00	709.00
IUUC-Ete-032409	Echinops telfairi	86.39	0.00e+00	1200.00
IUUC-Eca-033441	Equus caballus	94.79	0.00e+00	1453.00
IUUC-Eeu-034546	Erinaceus europaeus	78.20	0.00e+00	1183.00
IUUC-Fal-037547	Ficedula albicollis	80.57	0.00e+00	1312.00
IUUC-Fox-037774	Fusarium oxysporum	47.97	6.00e-157	547.00
IUUC-Gmo-039679	Gadus morhua	67.95	0.00e+00	1077.00
IUUC-Gga-040524	Gallus gallus	82.30	0.00e+00	1315.00
IUUC-Gac-042607	Gasterosteus aculeatus	67.47	0.00e+00	1100.00
IUUC-Hsa-046479	Homo sapiens	91.62	0.00e+00	2357.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	82.65	0.00e+00	1213.00
IUUC-Lch-050445	Latimeria chalumnae	59.30	0.00e+00	1452.00
IUUC-Loc-052645	Lepisosteus oculatus	73.90	0.00e+00	1192.00
IUUC-Lma-052980	Leptosphaeria maculans	45.57	1.00e-89	323.00
IUUC-Laf-053638	Loxodonta africana	83.51	0.00e+00	1356.00
IUUC-Mcc-055585	Macaca mulatta	91.47	0.00e+00	2325.00
IUUC-Meu-056897	Macropus eugenii	95.47	5.00e-171	595.00
IUUC-Mga-059362	Meleagris gallopavo	75.95	0.00e+00	1282.00
IUUC-Mvi-060395	Microbotryum violaceum	53.36	2.00e-148	519.00
IUUC-Mmr-061061	Microcebus murinus	92.01	0.00e+00	2381.00
IUUC-Mmu-063318	Mus musculus	77.90	0.00e+00	1233.00
IUUC-Mpu-066567	Mustela putorius furo	96.04	0.00e+00	1568.00
IUUC-Mlu-068148	Myotis lucifugus	89.59	0.00e+00	2286.00
IUUC-Nfi-068427	Neosartorya fischeri	48.48	2.00e-158	553.00
IUUC-Ncr-068918	Neurospora crassa	48.29	7.00e-157	547.00
IUUC-Nle-069225	Nomascus leucogenys	91.25	0.00e+00	2346.00
IUUC-Ont-071664	Oreochromis niloticus	65.94	0.00e+00	1061.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.76	0.00e+00	1382.00
IUUC-Ocu-074409	Oryctolagus cuniculus	87.11	0.00e+00	2227.00
IUUC-Oga-088241	Otolemur garnettii	85.92	0.00e+00	2103.00
IUUC-Oar-089797	Ovis aries	94.42	0.00e+00	1519.00
IUUC-Ptr-091629	Pan troglodytes	93.20	0.00e+00	1388.00
IUUC-Psi-093618	Pelodiscus sinensis	68.11	0.00e+00	1622.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.98	3.00e-163	568.00
IUUC-Pfo-097145	Poecilia formosa	68.68	0.00e+00	1065.00
IUUC-Pab-098394	Pongo abelii	94.29	0.00e+00	1510.00
IUUC-Pca-100568	Procavia capensis	77.96	0.00e+00	1155.00
IUUC-Pva-102303	Pteropus vampyrus	89.97	0.00e+00	1087.00
IUUC-Ptt-103806	Puccinia triticina	51.33	9.00e-119	421.00
IUUC-Pte-104016	Pyrenophora teres	49.15	3.00e-161	562.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.15	3.00e-161	562.00
IUUC-Rno-106095	Rattus norvegicus	79.13	0.00e+00	1249.00
IUUC-Sha-107370	Sarcophilus harrisii	67.52	0.00e+00	1757.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.54	1.00e-155	543.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.51	1.00e-157	550.00
IUUC-Tgu-117474	Taeniopygia guttata	81.19	0.00e+00	1323.00
IUUC-Tru-117675	Takifugu rubripes	64.92	0.00e+00	1067.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.39	0.00e+00	1062.00
IUUC-Tre-122203	Trichoderma reesei	46.98	2.00e-153	536.00
IUUC-Tvi-122595	Trichoderma virens	46.74	1.00e-153	536.00
IUUC-Tme-126897	Tuber melanosporum	48.38	2.00e-145	509.00
IUUC-Tbe-127408	Tupaia belangeri	86.72	0.00e+00	1164.00
IUUC-Ttr-128437	Tursiops truncatus	85.59	0.00e+00	1199.00
IUUC-Vpa-130503	Vicugna pacos	88.63	0.00e+00	1301.00
IUUC-Xtr-132431	Xenopus tropicalis	70.34	0.00e+00	1192.00
IUUC-Xma-133630	Xiphophorus maculatus	64.65	0.00e+00	1044.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence