iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000058898.1	ENSRNOT00000088391.1	ENSRNOP00000074683.1
ENSRNOG00000058898.1	ENSRNOT00000090258.1	ENSRNOP00000071377.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-132	442.8	557	886

Active Site

Position(s)	Description	Evidence
856	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 557  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 645
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k ++l+d+e+vd+e+y sl +i+en   d +e  ldl+f ++ee++g+t+++eLk+gG+++ Vtn+Nk+eY+ lv+++r
   Q: 646  IRPFYKMMLQKLITLHDMESVDSEYYSSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKTGGSEVVVTNKNKKEYIYLVIQWR 729
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++i+wFw+++ +++se+r ++LqFvTg
   Q: 730  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSLNHQVIHWFWKAVLMMDSEKRIRLLQFVTG 818
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++d+lP+++TCfn+L+LP+Y+s ++l +kL++Aie+t+gF+
   Q: 819  TSRVPMNGFAELYgsngPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFD 886
           *******************************************************************8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSSDMAADDT EAPVLSEDEV WEFCLDKNEE GGGSPGSDVT DTCEPPCGCW ELNPSSLEEE 60
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGVLTSVQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCGACGCC TCCTCCTCCT CTTCCTCTCC GGCTGCTGCA GCCTAGCAGG GGCGGTTCGT 60
CCAGTATGAG CTCGGACATG GCAGCCGACG ACACTGAGGC CCCAGTGCTT TCGGAGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

rno:25489

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	78.33	0.00e+00	1243.00
IUUC-Apl-003886	Anas platyrhynchos	66.67	0.00e+00	1215.00
IUUC-Bta-012453	Bos taurus	77.04	0.00e+00	1221.00
IUUC-Cel-018564	Caenorhabditis elegans	45.12	0.00e+00	639.00
IUUC-Cja-019034	Callithrix jacchus	76.40	0.00e+00	1102.00
IUUC-Cfa-020258	Canis familiaris	78.70	0.00e+00	1192.00
IUUC-Cpo-021648	Cavia porcellus	77.60	0.00e+00	1318.00
IUUC-Csa-023334	Chlorocebus sabaeus	80.02	0.00e+00	1363.00
IUUC-Cin-025157	Ciona intestinalis	52.49	0.00e+00	852.00
IUUC-Dre-027924	Danio rerio	61.60	0.00e+00	910.00
IUUC-Dno-029159	Dasypus novemcinctus	73.15	0.00e+00	1045.00
IUUC-Ete-032409	Echinops telfairi	70.89	0.00e+00	949.00
IUUC-Eca-033441	Equus caballus	79.91	0.00e+00	1330.00
IUUC-Eeu-034546	Erinaceus europaeus	65.80	0.00e+00	930.00
IUUC-Fca-036384	Felis catus	79.13	0.00e+00	1225.00
IUUC-Fal-037547	Ficedula albicollis	72.02	0.00e+00	1264.00
IUUC-Gmo-039679	Gadus morhua	64.89	0.00e+00	1106.00
IUUC-Gga-040524	Gallus gallus	72.38	0.00e+00	1256.00
IUUC-Hsa-046479	Homo sapiens	79.08	0.00e+00	1236.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	86.59	0.00e+00	1189.00
IUUC-Loc-052645	Lepisosteus oculatus	65.60	0.00e+00	1174.00
IUUC-Mcc-055585	Macaca mulatta	78.95	0.00e+00	1225.00
IUUC-Meu-056897	Macropus eugenii	92.68	1.00e-164	573.00
IUUC-Mga-059362	Meleagris gallopavo	66.15	0.00e+00	1235.00
IUUC-Mmr-061061	Microcebus murinus	78.98	0.00e+00	1250.00
IUUC-Mmu-063318	Mus musculus	96.29	0.00e+00	1736.00
IUUC-Mpu-066567	Mustela putorius furo	79.64	0.00e+00	1387.00
IUUC-Mlu-068148	Myotis lucifugus	78.23	0.00e+00	1215.00
IUUC-Nle-069225	Nomascus leucogenys	78.95	0.00e+00	1230.00
IUUC-Oan-073019	Ornithorhynchus anatinus	74.94	0.00e+00	1243.00
IUUC-Ocu-074409	Oryctolagus cuniculus	77.68	0.00e+00	1234.00
IUUC-Oga-088241	Otolemur garnettii	71.71	0.00e+00	1063.00
IUUC-Oar-089797	Ovis aries	79.06	0.00e+00	1336.00
IUUC-Ptr-091629	Pan troglodytes	76.40	0.00e+00	1094.00
IUUC-Psi-093618	Pelodiscus sinensis	72.39	0.00e+00	1127.00
IUUC-Pab-098394	Pongo abelii	79.89	0.00e+00	1360.00
IUUC-Pca-100568	Procavia capensis	68.72	0.00e+00	959.00
IUUC-Sha-107370	Sarcophilus harrisii	68.16	0.00e+00	1104.00
IUUC-Tgu-117474	Taeniopygia guttata	72.75	0.00e+00	1278.00
IUUC-Tru-117675	Takifugu rubripes	60.45	0.00e+00	1082.00
IUUC-Tbe-127408	Tupaia belangeri	72.44	0.00e+00	950.00
IUUC-Ttr-128437	Tursiops truncatus	71.05	0.00e+00	979.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence