iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034046

UUCD1 version

UUC-EqC-00665

Ensembl Protein ID

ENSECAP00000016095.1

UniProt Accession

F7AM44; F7AM44_HORSE

Protein Name

Uncharacterized protein

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000017677.1	ENSECAT00000019649.1	ENSECAP00000016095.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-86	290.1	4467	4796

Active Site

Position(s)	Description	Evidence
4765	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l +p      h+++F+flG+llg+a+++g +l
   Q: 4467 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLFSPaarapVHTNMFRFLGVLLGIAIRTGSPL 4553
           4566****************************************************99999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4554 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRTEYVR 4635
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4636 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSASLIQWFWEVMESFSNTERS 4720
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4721 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4796
           *************.8*************999988888***********************************99875 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MPSDSFCLAA QARLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIIYTGT ELTQNGELPP 60
RKDDGVDTQS GTKKEDLNDK EKKDEEEMPA PAYRAKSILE SWVWGKQPDV NELKECLSVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTGACAAC TGGGAGGATT TGGAGGGAAG ATGCCCTCTG ATTCTTTCTG TTTGGCTGCC 60
CAGGCTCGAC TTGACTCCAA ATGGTTGAAA ACGGATATCC AGGTGGGTTT TTGTACATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	97.54	0.00e+00	7197.00
IUUC-Atr-003065	Amborella trichopoda	35.29	3.00e-49	190.00
IUUC-Apl-003983	Anas platyrhynchos	90.59	0.00e+00	8342.00
IUUC-Aca-004300	Anolis carolinensis	89.59	0.00e+00	8204.00
IUUC-Ame-010621	Astyanax mexicanus	83.88	0.00e+00	6859.00
IUUC-Bta-013067	Bos taurus	96.53	0.00e+00	8698.00
IUUC-Bdi-014093	Brachypodium distachyon	32.97	2.00e-45	177.00
IUUC-Bol-015203	Brassica oleracea	33.99	2.00e-50	194.00
IUUC-Bra-016737	Brassica rapa	33.99	7.00e-46	179.00
IUUC-Cja-019687	Callithrix jacchus	93.82	0.00e+00	8384.00
IUUC-Cfa-020672	Canis familiaris	97.58	0.00e+00	8817.00
IUUC-Cpo-021819	Cavia porcellus	92.86	0.00e+00	8379.00
IUUC-Csa-023817	Chlorocebus sabaeus	95.64	0.00e+00	8641.00
IUUC-Cho-024387	Choloepus hoffmanni	93.01	0.00e+00	1836.00
IUUC-Cin-025709	Ciona intestinalis	58.53	0.00e+00	1438.00
IUUC-Csv-026336	Ciona savignyi	36.18	0.00e+00	1527.00
IUUC-Dre-027717	Danio rerio	81.71	0.00e+00	7222.00
IUUC-Dno-029296	Dasypus novemcinctus	94.77	0.00e+00	8558.00
IUUC-Dor-030979	Dipodomys ordii	88.95	0.00e+00	2823.00
IUUC-Dme-032171	Drosophila melanogaster	59.56	0.00e+00	1534.00
IUUC-Ete-032687	Echinops telfairi	85.12	0.00e+00	2883.00
IUUC-Eeu-034859	Erinaceus europaeus	85.04	0.00e+00	1961.00
IUUC-Fca-036262	Felis catus	97.52	0.00e+00	8826.00
IUUC-Fal-037562	Ficedula albicollis	90.31	0.00e+00	8251.00
IUUC-Gmo-039054	Gadus morhua	82.89	0.00e+00	1027.00
IUUC-Gga-040359	Gallus gallus	90.44	0.00e+00	8285.00
IUUC-Gac-041879	Gasterosteus aculeatus	90.39	0.00e+00	1038.00
IUUC-Ggo-044692	Gorilla gorilla	95.77	0.00e+00	4247.00
IUUC-Hsa-045995	Homo sapiens	95.80	0.00e+00	8684.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	95.05	0.00e+00	2423.00
IUUC-Lch-049808	Latimeria chalumnae	85.84	0.00e+00	3286.00
IUUC-Loc-052685	Lepisosteus oculatus	84.00	0.00e+00	7520.00
IUUC-Laf-053372	Loxodonta africana	94.46	0.00e+00	8528.00
IUUC-Mcc-054693	Macaca mulatta	95.70	0.00e+00	8671.00
IUUC-Meu-056660	Macropus eugenii	96.40	0.00e+00	1933.00
IUUC-Mga-059371	Meleagris gallopavo	90.38	0.00e+00	7131.00
IUUC-Mmr-060787	Microcebus murinus	96.13	0.00e+00	8750.00
IUUC-Mdo-062518	Monodelphis domestica	89.09	0.00e+00	8015.00
IUUC-Mmu-063690	Mus musculus	94.42	0.00e+00	8520.00
IUUC-Mpu-066478	Mustela putorius furo	97.34	0.00e+00	8759.00
IUUC-Mlu-067596	Myotis lucifugus	90.23	0.00e+00	4336.00
IUUC-Nle-069445	Nomascus leucogenys	95.38	0.00e+00	2162.00
IUUC-Opr-070990	Ochotona princeps	87.76	0.00e+00	2964.00
IUUC-Ont-072285	Oreochromis niloticus	82.24	0.00e+00	7285.00
IUUC-Oan-072721	Ornithorhynchus anatinus	85.77	0.00e+00	3397.00
IUUC-Ocu-074273	Oryctolagus cuniculus	95.42	0.00e+00	8626.00
IUUC-Obr-076107	Oryza brachyantha	33.16	2.00e-46	181.00
IUUC-Ola-087346	Oryzias latipes	92.14	0.00e+00	1201.00
IUUC-Oga-088742	Otolemur garnettii	94.99	0.00e+00	8519.00
IUUC-Oar-090093	Ovis aries	96.55	0.00e+00	8700.00
IUUC-Ptr-091034	Pan troglodytes	90.03	0.00e+00	5636.00
IUUC-Pan-092783	Papio anubis	93.31	0.00e+00	8417.00
IUUC-Psi-094027	Pelodiscus sinensis	90.51	0.00e+00	7939.00
IUUC-Pfo-096208	Poecilia formosa	79.95	0.00e+00	5947.00
IUUC-Pab-097681	Pongo abelii	93.29	0.00e+00	2590.00
IUUC-Pca-100705	Procavia capensis	91.50	0.00e+00	1106.00
IUUC-Pva-103147	Pteropus vampyrus	87.93	0.00e+00	2536.00
IUUC-Rno-105458	Rattus norvegicus	94.42	0.00e+00	8504.00
IUUC-Sha-106959	Sarcophilus harrisii	81.50	0.00e+00	6951.00
IUUC-Sit-109917	Setaria italica	34.62	8.00e-46	178.00
IUUC-Sly-110961	Solanum lycopersicum	35.11	1.00e-50	195.00
IUUC-Sar-113532	Sorex araneus	85.32	0.00e+00	1804.00
IUUC-Sbi-114352	Sorghum bicolor	32.35	5.00e-46	179.00
IUUC-Ssc-115337	Sus scrofa	94.70	0.00e+00	3089.00
IUUC-Tgu-116789	Taeniopygia guttata	90.30	0.00e+00	8278.00
IUUC-Tru-118129	Takifugu rubripes	81.77	0.00e+00	7324.00
IUUC-Tsy-119302	Tarsius syrichta	81.43	0.00e+00	1194.00
IUUC-Tni-120374	Tetraodon nigroviridis	80.33	0.00e+00	7176.00
IUUC-Tca-121094	Theobroma cacao	33.42	6.00e-52	199.00
IUUC-Tae-124157	Triticum aestivum	33.80	4.00e-47	183.00
IUUC-Tbe-128137	Tupaia belangeri	87.92	0.00e+00	2343.00
IUUC-Ttr-128273	Tursiops truncatus	91.80	0.00e+00	6389.00
IUUC-Vpa-130471	Vicugna pacos	84.23	0.00e+00	1488.00
IUUC-Xtr-132185	Xenopus tropicalis	85.18	0.00e+00	7681.00
IUUC-Xma-133233	Xiphophorus maculatus	82.21	0.00e+00	7288.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence