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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046173
UUCD1 version UUC-HoS-00282
Ensembl Protein ID ENSP00000428205.1
UniProt Accession Q969P5; A4KYM0; FBX32_HUMAN
Genbank Protein ID AAL16407.1; CAD12251.1; ABO37797.1; BAB71333.1; ENSP00000390790
Protein Name F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein
Genbank Nucleotide ID AY059629; AJ420108; EF143260; AK056986; AC090193
Gene Name FBXO32
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000156804.7 ENST00000517956.5 ENSP00000428205.1
ENSG00000156804.7 ENST00000443022.2 ENSP00000390790.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19117950; 15531760; 18354498; 19850579
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 95.49 0.00e+00 702.00 IUUC-Rno-105610
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Protein Sequence
(Fasta)
MPFLGQDWRS PGQNWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA 60
AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046173|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCACTCCCG GAGCCTGCAA CGCTTGAGAT CCTCTCCGCG CCCGCCACCC CGCAGGGTGC 60
CCCGCGCCGT TCCCGCCGCC CCGCCGCCCC CGTCGCGGGC CCCTGCACCC CGAGCATCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046173|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
KEGG hsa:114907
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001986 Ailuropoda melanoleuca 98.87 0.00e+00 732.00
IUUC-Apl-003973 Anas platyrhynchos 92.16 2.00e-178 618.00
IUUC-Aca-004945 Anolis carolinensis 89.30 0.00e+00 656.00
IUUC-Ame-011383 Astyanax mexicanus 75.21 6.00e-164 570.00
IUUC-Bta-013522 Bos taurus 98.03 0.00e+00 727.00
IUUC-Bci-013735 Botrytis cinerea 32.08 1.60e-01 32.00
IUUC-Bdi-014435 Brachypodium distachyon 37.50 8.00e-05 40.80
IUUC-Bol-015763 Brassica oleracea 28.81 4.80e-02 31.60
IUUC-Cja-019893 Callithrix jacchus 99.44 0.00e+00 734.00
IUUC-Cfa-021053 Canis familiaris 98.31 0.00e+00 728.00
IUUC-Cpo-021330 Cavia porcellus 97.46 0.00e+00 723.00
IUUC-Csa-023160 Chlorocebus sabaeus 99.72 0.00e+00 736.00
IUUC-Cho-024993 Choloepus hoffmanni 77.56 2.00e-131 461.00
IUUC-Cin-025462 Ciona intestinalis 29.79 2.00e-25 109.00
IUUC-Csv-025908 Ciona savignyi 30.13 8.00e-42 164.00
IUUC-Cme-027326 Cyanidioschyzon merolae 24.80 6.00e-03 33.90
IUUC-Dre-028707 Danio rerio 75.63 9.00e-161 559.00
IUUC-Dno-029334 Dasypus novemcinctus 98.03 0.00e+00 728.00
IUUC-Dor-030350 Dipodomys ordii 97.65 0.00e+00 683.00
IUUC-Dme-031699 Drosophila melanogaster 28.49 4.00e-31 128.00
IUUC-Ete-033123 Echinops telfairi 76.66 3.00e-133 467.00
IUUC-Eca-033246 Equus caballus 98.87 0.00e+00 728.00
IUUC-Eeu-035339 Erinaceus europaeus 97.40 7.00e-133 466.00
IUUC-Fca-035805 Felis catus 98.86 0.00e+00 722.00
IUUC-Fal-037424 Ficedula albicollis 91.55 0.00e+00 690.00
IUUC-Gga-040478 Gallus gallus 92.68 0.00e+00 694.00
IUUC-Gac-042238 Gasterosteus aculeatus 72.85 1.00e-156 545.00
IUUC-Ggo-045515 Gorilla gorilla 99.72 0.00e+00 736.00
IUUC-Itr-048038 Ictidomys tridecemlineatus 98.59 0.00e+00 729.00
IUUC-Lch-049820 Latimeria chalumnae 81.13 9.00e-175 605.00
IUUC-Loc-051732 Lepisosteus oculatus 78.59 1.00e-169 588.00
IUUC-Laf-053789 Loxodonta africana 96.36 0.00e+00 686.00
IUUC-Mcc-055119 Macaca mulatta 99.72 0.00e+00 736.00
IUUC-Meu-056262 Macropus eugenii 80.18 1.00e-96 346.00
IUUC-Mga-059869 Meleagris gallopavo 85.11 1.00e-175 608.00
IUUC-Mmr-061443 Microcebus murinus 99.15 0.00e+00 733.00
IUUC-Mdo-062355 Monodelphis domestica 95.49 0.00e+00 714.00
IUUC-Mmu-064306 Mus musculus 96.62 0.00e+00 717.00
IUUC-Mpu-066902 Mustela putorius furo 98.47 0.00e+00 639.00
IUUC-Mlu-067076 Myotis lucifugus 97.46 0.00e+00 719.00
IUUC-Nle-069716 Nomascus leucogenys 99.72 0.00e+00 736.00
IUUC-Ont-072007 Oreochromis niloticus 73.74 2.00e-155 541.00
IUUC-Oan-073321 Ornithorhynchus anatinus 95.32 1.00e-160 558.00
IUUC-Ocu-074320 Oryctolagus cuniculus 97.18 0.00e+00 694.00
IUUC-Ola-087193 Oryzias latipes 73.74 9.00e-160 556.00
IUUC-Oga-088558 Otolemur garnettii 98.31 0.00e+00 730.00
IUUC-Oar-090092 Ovis aries 97.75 0.00e+00 725.00
IUUC-Ptr-091443 Pan troglodytes 99.15 0.00e+00 731.00
IUUC-Pan-092207 Papio anubis 99.72 0.00e+00 736.00
IUUC-Psi-093282 Pelodiscus sinensis 91.06 0.00e+00 683.00
IUUC-Pma-094448 Petromyzon marinus 66.48 3.00e-143 501.00
IUUC-Pfo-096873 Poecilia formosa 74.30 1.00e-160 559.00
IUUC-Pca-101124 Procavia capensis 96.34 0.00e+00 709.00
IUUC-Pva-102791 Pteropus vampyrus 98.03 0.00e+00 725.00
IUUC-Rno-105610 Rattus norvegicus 95.49 0.00e+00 702.00
IUUC-Sha-106684 Sarcophilus harrisii 96.06 0.00e+00 715.00
IUUC-Smo-109491 Selaginella moellendorffii 22.35 2.00e-03 37.00
IUUC-Sar-113077 Sorex araneus 88.61 2.00e-165 575.00
IUUC-Ssc-115993 Sus scrofa 95.77 0.00e+00 701.00
IUUC-Tgu-117376 Taeniopygia guttata 91.22 1.00e-177 615.00
IUUC-Tru-118690 Takifugu rubripes 73.18 5.00e-159 553.00
IUUC-Tni-120740 Tetraodon nigroviridis 71.79 2.00e-158 551.00
IUUC-Tbe-127713 Tupaia belangeri 89.24 2.00e-164 571.00
IUUC-Ttr-128339 Tursiops truncatus 99.15 0.00e+00 733.00
IUUC-Vpa-130070 Vicugna pacos 97.83 9.00e-81 293.00
IUUC-Xtr-132470 Xenopus tropicalis 83.94 0.00e+00 629.00
IUUC-Xma-133649 Xiphophorus maculatus 73.74 8.00e-161 559.00
Created Date 25-Jun-2017

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