iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089456

Ensembl Protein ID

ENSOARP00000000543.1

UniProt Accession

W5NQV3; W5NQV3_SHEEP

Genbank Protein ID

ENSOARP00000000543

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01097192

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000530.1	ENSOART00000000572.1	ENSOARP00000000543.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-90	303.9	718	1039

Active Site

Position(s)	Description	Evidence
1009	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+++l+v+f+gE g d gGv  ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G l+g++l++ ++ 
   Q: 718  NEDLRRELMVSFSGEIGYDFGGVRAEFFYCLFQEMTRPEYGMFTYPEEASYMWFPVRPKF----EKKSYF-FFGLLCGLSLFNCNVA 799
           6899*******************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d+p++ +++k+ll++  sledl+e+ p l +sl+ +++ + +d+ee      f+++ ++  + ++++L+p+G++i V ++Nk++Yv+
   Q: 800  DIPFPLALFKKLLDQTPSLEDLKELSPVLGESLQTLLDDDGDDLEEV-----FHIHFNVHWDKNDVDLIPDGSHIIVDQTNKRDYVS 881
           *************************************8855555554.....555555677889999******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++v+y+++ ++k  +e+f++Gf++v+++e+++ F++e+l+ +i G++++d+e+++k++ y++gy +++p+i +Fw++l++++ ee+k
   Q: 882  KYVNYIFNISVKAVYEEFQRGFYKVCDKEIIEFFHPEQLKDVIIGNTDYDWETFEKNAHYEHGYDSSHPTIVMFWKALHKLTLEEKK 968
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++r+ ++G++++k   f++++  ++++ ++++TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 969  KFLVFLTGTDRIQVKGVKNMK-ITFCCPETLNEKDPIRAQTCFSVLYLPKYSTMERVEEALQVAINNSRGFG 1039
           *********************.77999999999*************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MEGRPRRRSR GGARPVSGRV PESRPSASRP SASRPSATAP AESWGAKLWL FPSAAGLRSA 60
LSKRPEATRQ MCCTRRRLAV LERGGAGVEV HQLPAGSDGA RKPKCIKLGK KMKIHSMDQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGGGA GGCCACGGAG GAGGTCGCGG GGCGGCGCAC GCCCGGTGTC CGGGCGGGTC 60
CCCGAGTCCC GACCCTCCGC GTCCCGGCCC TCCGCGTCCC GGCCCTCCGC GACAGCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	84.38	0.00e+00	1722.00
IUUC-Bta-012422	Bos taurus	84.24	0.00e+00	1563.00
IUUC-Cja-018751	Callithrix jacchus	74.73	0.00e+00	1519.00
IUUC-Cfa-020247	Canis familiaris	85.59	0.00e+00	1622.00
IUUC-Csa-023204	Chlorocebus sabaeus	76.94	0.00e+00	1378.00
IUUC-Cho-025101	Choloepus hoffmanni	66.20	0.00e+00	662.00
IUUC-Dno-029795	Dasypus novemcinctus	74.45	0.00e+00	1181.00
IUUC-Dor-030862	Dipodomys ordii	67.88	0.00e+00	1300.00
IUUC-Ete-032585	Echinops telfairi	61.07	0.00e+00	815.00
IUUC-Eca-034358	Equus caballus	82.63	0.00e+00	1582.00
IUUC-Eeu-035282	Erinaceus europaeus	71.11	0.00e+00	792.00
IUUC-Fca-036505	Felis catus	84.91	0.00e+00	1683.00
IUUC-Ggo-045445	Gorilla gorilla	73.76	0.00e+00	1446.00
IUUC-Hsa-046342	Homo sapiens	76.14	0.00e+00	1528.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	73.17	0.00e+00	1452.00
IUUC-Laf-053921	Loxodonta africana	75.60	0.00e+00	1488.00
IUUC-Mcc-054850	Macaca mulatta	76.72	0.00e+00	1378.00
IUUC-Mmr-060783	Microcebus murinus	67.84	0.00e+00	1212.00
IUUC-Mpu-066123	Mustela putorius furo	83.62	0.00e+00	1711.00
IUUC-Mlu-067914	Myotis lucifugus	81.09	0.00e+00	1480.00
IUUC-Nle-069986	Nomascus leucogenys	76.03	0.00e+00	1506.00
IUUC-Opr-070513	Ochotona princeps	70.37	0.00e+00	1064.00
IUUC-Ocu-074305	Oryctolagus cuniculus	74.44	0.00e+00	1418.00
IUUC-Ptr-091216	Pan troglodytes	76.23	0.00e+00	1320.00
IUUC-Pan-091706	Papio anubis	75.37	0.00e+00	1471.00
IUUC-Pca-100320	Procavia capensis	68.50	0.00e+00	1360.00
IUUC-Pva-102646	Pteropus vampyrus	85.59	0.00e+00	1729.00
IUUC-Sar-113605	Sorex araneus	79.04	8.00e-154	537.00
IUUC-Ssc-116076	Sus scrofa	84.30	0.00e+00	644.00
IUUC-Tsy-119240	Tarsius syrichta	66.27	0.00e+00	1228.00
IUUC-Tbe-127787	Tupaia belangeri	74.20	0.00e+00	1363.00
IUUC-Ttr-128191	Tursiops truncatus	83.53	0.00e+00	1659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence