iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	11406394
UBD/Alpha-Helix/UIM	UIM	11406394
E3 activity/HECT	HECT	12969426

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	5.10e-122	408.3	3341	3680
UBD/Alpha-Helix/UBA	6.10e-07	30.3	1271	1309
UBD/Alpha-Helix/UBM	2.50e-13	50.1	2646	2670

Active Site

Position(s)	Description	Evidence
3648	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfy 97
           ++dlk rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ ++++t+qpnp+s ++ +ehl++F+f+Gr+++kal+dg+lld+ +++sfy
   Q: 3341 PQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNDATFQPNPNSVYQ-TEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFY 3434
           689************************************9999.556678889******986.5******************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.......lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           k++lg+k++++d+e+vdp++yk+lk+++en   d++++ ldltfs++ ++         e++++eLkpgG+ni+Vt+e k+eYv+lv+ ++l++ i
   Q: 3435 KHILGVKVTYHDIEAVDPDYYKNLKWLLEN---DVSDI-LDLTFSMDADEekhilyeKTEVTDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAI 3526
           ****************************99...88887.88888866666668895555566778******************************* PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfael 282
           + q++af eGfne+ip el+s+F+ +elelli+G +eid++dlk++t+y++ yt+ sp+i+wFwev+++fs+e+ ++fLqFvTg+s++Pl+Gf++l
   Q: 3527 RPQINAFLEGFNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTS-YTAGSPVIHWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKAL 3621
           *************************************************99.******************************************** PP
   S: 283  k....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +    p++ +i+k +++++rlPs++TCfn+L+LPeY+ske+l+e+Ll+Ai+e+ +gF++
   Q: 3622 QgisgPQRLQIHKaYGAPERLPSAHTCFNQLDLPEYQSKEQLQERLLLAIHEAsEGFGF 3680
           *************99999***************************************86 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLld 40
           de+++  +veMGF+r++a  aLr+   n++e+A+++L++
   Q: 1271 DESIVGMIVEMGFSRSRAEIALRRVgTNSVEMAMDWLFT 1309
           68889999******************************8 PP

UBD/Alpha-Helix/UBM

   S: 4    qvDpeVfsqLPeeiQeEvmaelrqq 28
           ++Dpe++++LP++iQ Ev+a +r q
   Q: 2646 DIDPEFLAALPPDIQTEVLAQQRAQ 2670
           79******************99976 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MKLRRRRASE VPSKIKSFIN SVTSVPLELI HEPLACFRWE FDKGDFHHWV DLFNYFDTFF 60
EKHVQVRKDL HIEENFEESD PPFPKDAVLQ VLRVIRVVLE NCTNKHFYSS YEQHLSLLLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATCTTC TCCACTTCTC TTTCTCTCTC ACACCGTCTT TCTCTCTCCC TATCAAATCC 60
CTTCTCTTCT AATACGCGAT CCTCTTTTAA ACCCTAGTTT CGGATCGCTC TTACACTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ath:AT1G55860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001684	Ailuropoda melanoleuca	51.77	1.00e-128	456.00
IUUC-Atr-003044	Amborella trichopoda	56.59	0.00e+00	3497.00
IUUC-Apl-003513	Anas platyrhynchos	45.20	1.00e-92	333.00
IUUC-Aca-005263	Anolis carolinensis	51.99	3.00e-129	457.00
IUUC-Aly-006083	Arabidopsis lyrata	94.21	0.00e+00	6371.00
IUUC-Acl-008254	Aspergillus clavatus	43.61	2.00e-138	488.00
IUUC-Afl-008712	Aspergillus flavus	44.10	9.00e-140	490.00
IUUC-Afu-009022	Aspergillus fumigatus	43.27	9.00e-139	489.00
IUUC-Ang-009771	Aspergillus niger	43.95	3.00e-140	494.00
IUUC-Ate-010253	Aspergillus terreus	43.78	2.00e-139	491.00
IUUC-Ame-011067	Astyanax mexicanus	51.54	2.00e-127	451.00
IUUC-Bgr-012043	Blumeria graminis	45.01	7.00e-135	476.00
IUUC-Bta-012813	Bos taurus	51.77	1.00e-128	456.00
IUUC-Bci-013995	Botrytis cinerea	45.81	4.00e-139	490.00
IUUC-Bdi-014884	Brachypodium distachyon	35.98	0.00e+00	1072.00
IUUC-Bra-016637	Brassica rapa	82.52	0.00e+00	5509.00
IUUC-Cel-018179	Caenorhabditis elegans	48.25	2.00e-119	424.00
IUUC-Cja-018741	Callithrix jacchus	51.88	5.00e-128	453.00
IUUC-Cfa-020083	Canis familiaris	51.77	9.00e-129	456.00
IUUC-Cpo-021923	Cavia porcellus	44.04	2.00e-95	345.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	60.61	4.00e-156	543.00
IUUC-Csa-023853	Chlorocebus sabaeus	51.77	1.00e-128	456.00
IUUC-Cho-024718	Choloepus hoffmanni	55.24	5.00e-119	423.00
IUUC-Cin-025627	Ciona intestinalis	49.32	4.00e-122	434.00
IUUC-Csv-025872	Ciona savignyi	49.55	9.00e-120	422.00
IUUC-Dre-028525	Danio rerio	50.00	8.00e-113	403.00
IUUC-Dno-029680	Dasypus novemcinctus	51.77	1.00e-128	456.00
IUUC-Dor-030902	Dipodomys ordii	46.46	2.00e-109	391.00
IUUC-Dse-031197	Dothistroma septosporum	39.59	2.00e-132	468.00
IUUC-Dme-032122	Drosophila melanogaster	48.99	2.00e-122	435.00
IUUC-Eca-033915	Equus caballus	51.22	1.00e-126	449.00
IUUC-Eeu-034963	Erinaceus europaeus	51.43	9.00e-127	449.00
IUUC-Fca-035824	Felis catus	51.77	1.00e-128	456.00
IUUC-Fal-037275	Ficedula albicollis	45.45	4.00e-93	335.00
IUUC-Gmo-039073	Gadus morhua	51.77	9.00e-129	456.00
IUUC-Gga-040309	Gallus gallus	57.32	1.00e-98	352.00
IUUC-Gac-042430	Gasterosteus aculeatus	51.77	9.00e-129	456.00
IUUC-Gma-044247	Glycine max	63.20	0.00e+00	4004.00
IUUC-Ggo-044449	Gorilla gorilla	44.95	9.00e-92	329.00
IUUC-Hsa-046879	Homo sapiens	51.77	1.00e-128	456.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	51.77	7.00e-129	455.00
IUUC-Lch-050252	Latimeria chalumnae	51.88	5.00e-128	453.00
IUUC-Lpe-050915	Leersia perrieri	53.94	0.00e+00	3313.00
IUUC-Loc-052472	Lepisosteus oculatus	51.55	2.00e-128	455.00
IUUC-Lma-053159	Leptosphaeria maculans	31.91	5.00e-141	496.00
IUUC-Laf-054154	Loxodonta africana	51.77	1.00e-128	456.00
IUUC-Mcc-055085	Macaca mulatta	51.77	1.00e-128	456.00
IUUC-Mtr-058088	Medicago truncatula	61.57	0.00e+00	2398.00
IUUC-Mla-058888	Melampsora laricipopulina	46.47	2.00e-112	398.00
IUUC-Mga-059481	Meleagris gallopavo	45.20	3.00e-93	335.00
IUUC-Mvi-060320	Microbotryum violaceum	45.47	2.00e-124	441.00
IUUC-Mmr-060820	Microcebus murinus	51.77	8.00e-129	456.00
IUUC-Mdo-062930	Monodelphis domestica	51.77	5.00e-129	457.00
IUUC-Mmu-063601	Mus musculus	51.77	8.00e-129	456.00
IUUC-Mac-065557	Musa acuminata	50.12	0.00e+00	1424.00
IUUC-Mpu-066653	Mustela putorius furo	51.77	8.00e-129	456.00
IUUC-Mlu-067418	Myotis lucifugus	51.77	7.00e-129	456.00
IUUC-Nfi-068278	Neosartorya fischeri	43.61	3.00e-139	490.00
IUUC-Nle-069418	Nomascus leucogenys	51.77	1.00e-128	455.00
IUUC-Opr-070443	Ochotona princeps	44.39	8.00e-92	331.00
IUUC-Ont-071300	Oreochromis niloticus	51.77	1.00e-128	456.00
IUUC-Oan-073046	Ornithorhynchus anatinus	51.54	1.00e-127	452.00
IUUC-Ocu-074178	Oryctolagus cuniculus	51.77	7.00e-129	456.00
IUUC-Oba-075252	Oryza barthii	54.66	0.00e+00	3311.00
IUUC-Obr-076762	Oryza brachyantha	53.87	0.00e+00	3285.00
IUUC-Ogl-077590	Oryza glaberrima	55.35	0.00e+00	1165.00
IUUC-Ogu-077981	Oryza glumaepatula	52.42	0.00e+00	2046.00
IUUC-Oin-079663	Oryza indica	53.20	0.00e+00	3060.00
IUUC-Olo-080326	Oryza longistaminata	54.63	0.00e+00	3293.00
IUUC-Oni-082342	Oryza nivara	54.60	0.00e+00	3340.00
IUUC-Opu-083428	Oryza punctata	54.50	0.00e+00	3276.00
IUUC-Oru-084559	Oryza rufipogon	54.69	0.00e+00	3310.00
IUUC-Olu-087813	Ostreococcus lucimarinus	51.34	5.00e-125	440.00
IUUC-Oga-088903	Otolemur garnettii	51.77	8.00e-129	456.00
IUUC-Oar-090210	Ovis aries	51.77	1.00e-128	456.00
IUUC-Ptr-091629	Pan troglodytes	44.90	3.00e-92	333.00
IUUC-Pan-092368	Papio anubis	50.24	9.00e-114	406.00
IUUC-Pma-094364	Petromyzon marinus	43.38	2.00e-87	315.00
IUUC-Pno-094871	Phaeosphaeria nodorum	31.70	1.00e-135	478.00
IUUC-Ppa-095834	Physcomitrella patens	47.94	0.00e+00	1691.00
IUUC-Pfo-096232	Poecilia formosa	51.77	7.00e-129	456.00
IUUC-Pab-098583	Pongo abelii	51.77	1.00e-128	456.00
IUUC-Pop-099520	Populus trichocarpa	63.43	0.00e+00	4185.00
IUUC-Pca-100596	Procavia capensis	43.94	4.00e-87	315.00
IUUC-Ppe-102109	Prunus persica	65.56	0.00e+00	4303.00
IUUC-Pva-102116	Pteropus vampyrus	47.67	1.00e-113	406.00
IUUC-Pgr-103465	Puccinia graminis	40.71	1.00e-123	439.00
IUUC-Ptt-103813	Puccinia triticina	38.73	2.00e-114	408.00
IUUC-Pte-104018	Pyrenophora teres	31.81	5.00e-142	499.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	32.02	3.00e-136	481.00
IUUC-Sha-106961	Sarcophilus harrisii	51.77	6.00e-129	456.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	44.25	4.00e-96	345.00
IUUC-Smo-109428	Selaginella moellendorffii	42.56	0.00e+00	1548.00
IUUC-Sit-110149	Setaria italica	54.36	0.00e+00	3188.00
IUUC-Sly-111285	Solanum lycopersicum	61.93	0.00e+00	4075.00
IUUC-Sar-113291	Sorex araneus	52.86	6.00e-124	440.00
IUUC-Sbi-113794	Sorghum bicolor	51.47	0.00e+00	3088.00
IUUC-Sre-114958	Sporisorium reilianum	51.12	7.00e-141	493.00
IUUC-Ssc-115754	Sus scrofa	51.77	9.00e-129	456.00
IUUC-Tgu-116632	Taeniopygia guttata	43.78	7.00e-93	334.00
IUUC-Tru-118570	Takifugu rubripes	51.77	5.00e-129	456.00
IUUC-Tsy-119407	Tarsius syrichta	47.37	4.00e-91	328.00
IUUC-Tni-120836	Tetraodon nigroviridis	51.11	4.00e-125	443.00
IUUC-Tca-121646	Theobroma cacao	66.93	0.00e+00	4341.00
IUUC-Tre-121909	Trichoderma reesei	45.64	5.00e-139	490.00
IUUC-Tbe-127793	Tupaia belangeri	43.13	3.00e-84	305.00
IUUC-Ttr-129253	Tursiops truncatus	51.77	2.00e-128	455.00
IUUC-Uma-129355	Ustilago maydis	51.94	2.00e-144	505.00
IUUC-Vpa-130708	Vicugna pacos	51.77	3.00e-128	454.00
IUUC-Vvi-131559	Vitis vinifera	67.11	0.00e+00	1806.00
IUUC-Xtr-132123	Xenopus tropicalis	49.46	7.00e-116	413.00
IUUC-Xma-133869	Xiphophorus maculatus	51.77	6.00e-129	457.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence