iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132176

UUCD1 version

UUC-XeT-00001

Ensembl Protein ID

ENSXETP00000029095.2

UniProt Accession

Q28BK1; G1K3F9; HACE1_XENTR

Genbank Protein ID

CAJ83645.1; ENSXETP00000029095

Protein Name

E3 ubiquitin-protein ligase HACE1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1

Genbank Nucleotide ID

CR942795; AAMC01096447

Gene Name

hace1; TEgg040h18.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000013282.2	ENSXETT00000029095.2	ENSXETP00000029095.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-118	396.7	611	940

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G +lg+al++++l+++ 
   Q: 611  EKLKQGIAVRFHGEEGMGQ-GVVREWFDILSSEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGEILGLALYHRQLVNIY 696
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt+eNk eYv+lv+e+
   Q: 697  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 782
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++ f +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++d+++iqwFwev++e+++eer  +LqFvT
   Q: 783  RMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGYERDDQVIQWFWEVVQELTQEERVLLLQFVT 871
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i   + +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 872  GSSRVPHGGFAYIMggsgLQNFTIAAvAYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 940
           ******************8888888878899********************************986555 PP

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVLELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKRGAD PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCAAGAT ATTATTTAAC CATTTTATGC GCCGCTGCCC GTTGCAAATA AAGAACAGGC 60
GCCTGTTTGT CGCTCCTAAA TCTTGTCGCC CTAGGCCCGG GCCTGGGGGC CTCTCCCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0032580--C:Golgi cisterna membrane
GO:0000139--C:Golgi membrane
GO:0017137--F:Rab GTPase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007049--P:cell cycle
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

KEGG

xtr:734146

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	86.80	0.00e+00	1686.00
IUUC-Apl-003400	Anas platyrhynchos	88.54	0.00e+00	1181.00
IUUC-Aca-005375	Anolis carolinensis	86.35	0.00e+00	1683.00
IUUC-Ame-011847	Astyanax mexicanus	84.43	0.00e+00	1658.00
IUUC-Bta-012831	Bos taurus	87.27	0.00e+00	1655.00
IUUC-Cja-019160	Callithrix jacchus	87.83	0.00e+00	1709.00
IUUC-Cfa-020346	Canis familiaris	87.18	0.00e+00	1697.00
IUUC-Cpo-021766	Cavia porcellus	86.97	0.00e+00	1695.00
IUUC-Csa-023768	Chlorocebus sabaeus	87.71	0.00e+00	1709.00
IUUC-Cho-024688	Choloepus hoffmanni	80.35	0.00e+00	1038.00
IUUC-Cin-025417	Ciona intestinalis	52.15	7.00e-142	497.00
IUUC-Csv-025993	Ciona savignyi	45.47	5.00e-139	488.00
IUUC-Dre-027819	Danio rerio	82.49	0.00e+00	1624.00
IUUC-Dno-029027	Dasypus novemcinctus	86.83	0.00e+00	1689.00
IUUC-Dor-030327	Dipodomys ordii	80.28	0.00e+00	1477.00
IUUC-Ete-032966	Echinops telfairi	81.04	0.00e+00	1563.00
IUUC-Eca-034339	Equus caballus	87.39	0.00e+00	1701.00
IUUC-Eeu-034544	Erinaceus europaeus	77.60	3.00e-141	496.00
IUUC-Fca-035617	Felis catus	84.04	0.00e+00	1175.00
IUUC-Fal-036687	Ficedula albicollis	90.68	0.00e+00	1786.00
IUUC-Gmo-039508	Gadus morhua	88.84	0.00e+00	839.00
IUUC-Gga-040845	Gallus gallus	90.57	0.00e+00	1791.00
IUUC-Gac-041894	Gasterosteus aculeatus	83.37	0.00e+00	1593.00
IUUC-Ggo-044465	Gorilla gorilla	84.27	0.00e+00	1631.00
IUUC-Hsa-045731	Homo sapiens	87.71	0.00e+00	1711.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	87.61	0.00e+00	1707.00
IUUC-Lch-050436	Latimeria chalumnae	85.92	0.00e+00	1680.00
IUUC-Loc-052287	Lepisosteus oculatus	86.37	0.00e+00	1716.00
IUUC-Laf-053846	Loxodonta africana	87.61	0.00e+00	1707.00
IUUC-Mcc-055845	Macaca mulatta	87.82	0.00e+00	1712.00
IUUC-Meu-056060	Macropus eugenii	85.49	0.00e+00	662.00
IUUC-Mga-059935	Meleagris gallopavo	88.01	0.00e+00	1703.00
IUUC-Mmr-060960	Microcebus murinus	87.61	0.00e+00	1707.00
IUUC-Mdo-061851	Monodelphis domestica	89.62	0.00e+00	1764.00
IUUC-Mmu-063657	Mus musculus	87.29	0.00e+00	1700.00
IUUC-Mpu-066161	Mustela putorius furo	93.72	0.00e+00	789.00
IUUC-Mlu-067354	Myotis lucifugus	85.24	0.00e+00	1620.00
IUUC-Nle-069112	Nomascus leucogenys	87.71	0.00e+00	1712.00
IUUC-Opr-070686	Ochotona princeps	84.74	0.00e+00	776.00
IUUC-Ont-072398	Oreochromis niloticus	82.37	0.00e+00	1592.00
IUUC-Oan-073194	Ornithorhynchus anatinus	86.59	0.00e+00	1628.00
IUUC-Ocu-074397	Oryctolagus cuniculus	78.43	0.00e+00	1478.00
IUUC-Ola-086777	Oryzias latipes	82.97	0.00e+00	1602.00
IUUC-Oga-088684	Otolemur garnettii	87.51	0.00e+00	1701.00
IUUC-Oar-089428	Ovis aries	86.57	0.00e+00	1661.00
IUUC-Ptr-090529	Pan troglodytes	87.61	0.00e+00	1708.00
IUUC-Pan-091702	Papio anubis	87.71	0.00e+00	1710.00
IUUC-Psi-093969	Pelodiscus sinensis	89.34	0.00e+00	1707.00
IUUC-Pfo-097364	Poecilia formosa	83.23	0.00e+00	1602.00
IUUC-Pab-098574	Pongo abelii	87.71	0.00e+00	1711.00
IUUC-Pca-100525	Procavia capensis	82.12	1.00e-170	593.00
IUUC-Pva-102365	Pteropus vampyrus	76.91	0.00e+00	1443.00
IUUC-Rno-105153	Rattus norvegicus	87.39	0.00e+00	1704.00
IUUC-Sha-107319	Sarcophilus harrisii	89.83	0.00e+00	1766.00
IUUC-Stu-112894	Solanum tuberosum	34.19	4.00e-54	206.00
IUUC-Sar-113449	Sorex araneus	64.57	3.00e-142	499.00
IUUC-Ssc-115865	Sus scrofa	87.39	0.00e+00	1700.00
IUUC-Tgu-117225	Taeniopygia guttata	90.57	0.00e+00	1794.00
IUUC-Tru-118026	Takifugu rubripes	82.57	0.00e+00	1587.00
IUUC-Tsy-119407	Tarsius syrichta	75.42	0.00e+00	1408.00
IUUC-Tni-120234	Tetraodon nigroviridis	81.45	0.00e+00	1263.00
IUUC-Tbe-127708	Tupaia belangeri	73.65	0.00e+00	755.00
IUUC-Ttr-128667	Tursiops truncatus	87.29	0.00e+00	1700.00
IUUC-Vpa-130200	Vicugna pacos	86.82	0.00e+00	1638.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence