iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132293

Ensembl Protein ID

ENSXETP00000046165.2

UniProt Accession

F6S8L5; F6S8L5_XENTR

Genbank Protein ID

ENSXETP00000046165

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01064150

Gene Name

fyn

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000021344.3	ENSXETT00000046165.2	ENSXETP00000046165.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-15	56.0	87	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARTEDDLSFQKGEKFQIL--NSSEGDWWEARSLTTGGTGYIPSNYVAPVD 142
           789***********************..89999*********************9987 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MGCVQCKDKE ATKLTDERDN SLTQSLGYRY GTDPTPQHYP SFTVTTIPNY NNFHTNAGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFQKGEKFQ ILNSSEGDWW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTTTTAGG GAGACTAAAA GAAGCAATGT GGTGAAATCA AGTTACCATA GCTTGGGAAA 60
ATATTGGTAA GTCTGTGGCT CTTATTATAT AATGTTAGAG TTGACTTTTT GGGGGATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	90.50	0.00e+00	981.00
IUUC-Apl-003716	Anas platyrhynchos	95.71	0.00e+00	1036.00
IUUC-Aca-005065	Anolis carolinensis	90.69	0.00e+00	979.00
IUUC-Ame-011876	Astyanax mexicanus	83.83	0.00e+00	896.00
IUUC-Bta-012645	Bos taurus	90.50	0.00e+00	980.00
IUUC-Cja-019027	Callithrix jacchus	90.50	0.00e+00	981.00
IUUC-Cfa-021163	Canis familiaris	90.50	0.00e+00	981.00
IUUC-Cpo-022315	Cavia porcellus	90.50	0.00e+00	981.00
IUUC-Csa-023721	Chlorocebus sabaeus	90.32	0.00e+00	979.00
IUUC-Cho-025014	Choloepus hoffmanni	90.69	0.00e+00	983.00
IUUC-Dre-027985	Danio rerio	86.78	0.00e+00	984.00
IUUC-Dno-030043	Dasypus novemcinctus	84.72	0.00e+00	985.00
IUUC-Dor-031035	Dipodomys ordii	89.20	0.00e+00	960.00
IUUC-Eeu-034582	Erinaceus europaeus	86.17	2.00e-168	585.00
IUUC-Fca-035582	Felis catus	90.50	0.00e+00	981.00
IUUC-Fal-037320	Ficedula albicollis	96.07	0.00e+00	1041.00
IUUC-Gmo-038992	Gadus morhua	85.34	0.00e+00	961.00
IUUC-Gga-041262	Gallus gallus	96.07	0.00e+00	1041.00
IUUC-Gac-042461	Gasterosteus aculeatus	84.73	0.00e+00	962.00
IUUC-Ggo-044469	Gorilla gorilla	89.41	0.00e+00	974.00
IUUC-Hsa-045723	Homo sapiens	90.32	0.00e+00	979.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	90.50	0.00e+00	981.00
IUUC-Lch-049825	Latimeria chalumnae	87.52	0.00e+00	942.00
IUUC-Loc-052531	Lepisosteus oculatus	84.92	0.00e+00	962.00
IUUC-Laf-053659	Loxodonta africana	90.32	0.00e+00	979.00
IUUC-Mcc-055039	Macaca mulatta	93.51	0.00e+00	1020.00
IUUC-Mga-060067	Meleagris gallopavo	91.08	0.00e+00	983.00
IUUC-Mmr-061194	Microcebus murinus	90.50	0.00e+00	981.00
IUUC-Mdo-062628	Monodelphis domestica	90.32	0.00e+00	979.00
IUUC-Mmu-063896	Mus musculus	90.50	0.00e+00	981.00
IUUC-Mpu-066333	Mustela putorius furo	90.88	0.00e+00	985.00
IUUC-Mlu-067315	Myotis lucifugus	90.50	0.00e+00	981.00
IUUC-Nle-068978	Nomascus leucogenys	94.57	0.00e+00	1028.00
IUUC-Ont-071783	Oreochromis niloticus	86.22	0.00e+00	947.00
IUUC-Oan-073714	Ornithorhynchus anatinus	90.77	0.00e+00	858.00
IUUC-Ocu-074284	Oryctolagus cuniculus	90.32	0.00e+00	979.00
IUUC-Ola-087431	Oryzias latipes	86.46	0.00e+00	974.00
IUUC-Oga-088789	Otolemur garnettii	94.94	0.00e+00	1033.00
IUUC-Oar-089408	Ovis aries	90.50	0.00e+00	980.00
IUUC-Ptr-091068	Pan troglodytes	90.32	0.00e+00	979.00
IUUC-Pan-092217	Papio anubis	90.32	0.00e+00	979.00
IUUC-Psi-093602	Pelodiscus sinensis	91.06	0.00e+00	986.00
IUUC-Pfo-097084	Poecilia formosa	86.78	0.00e+00	981.00
IUUC-Pab-097673	Pongo abelii	89.94	0.00e+00	975.00
IUUC-Pca-100245	Procavia capensis	88.48	0.00e+00	874.00
IUUC-Pva-102645	Pteropus vampyrus	89.55	0.00e+00	952.00
IUUC-Rno-105372	Rattus norvegicus	90.32	0.00e+00	979.00
IUUC-Sha-107637	Sarcophilus harrisii	90.13	0.00e+00	967.00
IUUC-Sar-113016	Sorex araneus	79.33	0.00e+00	835.00
IUUC-Ssc-116389	Sus scrofa	90.13	0.00e+00	974.00
IUUC-Tgu-117206	Taeniopygia guttata	96.07	0.00e+00	1041.00
IUUC-Tru-118241	Takifugu rubripes	85.40	0.00e+00	969.00
IUUC-Tni-120031	Tetraodon nigroviridis	85.85	0.00e+00	967.00
IUUC-Tbe-127707	Tupaia belangeri	88.01	0.00e+00	875.00
IUUC-Ttr-129145	Tursiops truncatus	90.50	0.00e+00	981.00
IUUC-Vpa-130815	Vicugna pacos	87.64	0.00e+00	925.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence