iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046598

UUCD1 version

UUC-HoS-01171

Ensembl Protein ID

ENSP00000382858.2

UniProt Accession

Q9Y5T5; A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; UBP16_HUMAN

Genbank Protein ID

AAD20949.1; AAR13293.1; BAG51175.1; BAG63599.1; BAG57569.1; BAD96401.1; BAD96604.1; CAB90432.1; EAX09927.1; EAX09929.1; AAH30777.1; AAG39290.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AF126736; AY333928; AK023247; AK302247; AK294284; AK222681; AK222884; AL163249; AF129075; CH471079; BC030777; AF113219

Gene Name

USP16; MSTP039

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156256.14	ENST00000399975.7	ENSP00000382857.3
ENSG00000156256.14	ENST00000399976.6	ENSP00000382858.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20550933; 11753566
UBD/ZnF/ZnF_UBP	ZnF_UBP	17512543

Classification

Family	E-value	Score	Start	End
DUB/USP	9.40e-91	306.2	196	821

Active Site

Position(s)	Description	Evidence
205	Nucleophile
758	Proton acceptor	ECO:0000255\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkkavsp 70
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk++v+p
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGVVTP 278
           5******************************86555555540.........24555555555658899************************ PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikcl 157
           +el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+s i+c 
   Q: 279  KELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSMPSFVDRIFGGELTSMIMCD 370
           **********************************************************99999999************************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke................................................................ 185
           +c++vs  +e+fldlslpv ++++ kk+                                                                
   Q: 371  QCRTVSLVHESFLDLSLPVLDDQSGKKSvndknlkktvededqdseeekdndsyikersdipsgtskhlqkkakkqakkqaknqrrqqkiqg 462
           ***********************99999**************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 463  kvlhlndictidhpedseyeaemslqgevniksnhisqegvmhkeycvnqkdlngqakmiesvtdnqksteevdmkninmdndlevltsspt 554
           ******************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftkeeel 200
                                                                                        s+q+cL +ft++e+l
   Q: 555  rnlngayltegsngevdisngfknlnlnaalhpdeinieilndshtpgtkvyevvnedpetafctlanrevfntdecSIQHCLYQFTRNEKL 646
           ******************************************************************************************** PP
   S: 201  egenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke. 274
           +++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++fp+ Ldl+pfct ++++++e 
   Q: 647  RDANKLLCEVCTRRQCngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEe 736
           ************888899999999999999999*********************..9999************************99998877 PP
   S: 275  ..kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
             ++ Y+L++vv HsG+++sGHY+ay+k                        +kg+W++++D++V++v+ ++vl+   s+aY+lfY+r
   Q: 737  ntRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemeSKGQWFHISDTHVQAVPTTKVLN---SQAYLLFYER 821
           77999************************999999999999999999999888999*******************...********98 PP

Organism

Homo sapiens

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAATGCCGC GTTCCGGAAG TTATTGCTTT CCAGGGGTCA CTCTGGCTTC GACTCCGTCG 60
CTCTCAATTC GTCACCAGGA GGAAGACGGA GCTGGCTGCC CAGCCCAAAG GCCCATGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016578--P:histone deubiquitination
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045901--P:positive regulation of translational elongation
GO:0016579--P:protein deubiquitination
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:10600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	35.81	2.00e-27	118.00
IUUC-Aml-001931	Ailuropoda melanoleuca	91.90	0.00e+00	1405.00
IUUC-Atr-003015	Amborella trichopoda	31.18	1.00e-34	142.00
IUUC-Apl-004145	Anas platyrhynchos	63.43	0.00e+00	916.00
IUUC-Aca-004314	Anolis carolinensis	59.51	0.00e+00	888.00
IUUC-Aly-006422	Arabidopsis lyrata	29.17	2.00e-28	122.00
IUUC-Ath-006732	Arabidopsis thaliana	32.65	7.00e-32	133.00
IUUC-Afl-008729	Aspergillus flavus	28.42	6.00e-14	72.80
IUUC-Aor-009965	Aspergillus oryzae	28.72	2.00e-14	74.70
IUUC-Ame-011659	Astyanax mexicanus	49.32	6.00e-110	392.00
IUUC-Bta-013362	Bos taurus	90.69	0.00e+00	1399.00
IUUC-Bdi-014465	Brachypodium distachyon	31.91	2.00e-30	128.00
IUUC-Bol-015941	Brassica oleracea	29.76	2.00e-32	134.00
IUUC-Bra-016751	Brassica rapa	29.12	4.00e-30	127.00
IUUC-Cja-019177	Callithrix jacchus	95.88	0.00e+00	1523.00
IUUC-Cfa-020051	Canis familiaris	91.78	0.00e+00	1421.00
IUUC-Cpo-021886	Cavia porcellus	81.91	0.00e+00	1301.00
IUUC-Csa-024103	Chlorocebus sabaeus	97.82	0.00e+00	1553.00
IUUC-Cho-024315	Choloepus hoffmanni	78.12	8.00e-128	451.00
IUUC-Cin-025775	Ciona intestinalis	51.77	2.00e-39	154.00
IUUC-Csv-026075	Ciona savignyi	52.15	3.00e-60	226.00
IUUC-Cme-027348	Cyanidioschyzon merolae	39.46	5.00e-20	93.20
IUUC-Dre-028388	Danio rerio	46.65	0.00e+00	643.00
IUUC-Dno-029409	Dasypus novemcinctus	89.00	0.00e+00	1401.00
IUUC-Dor-030443	Dipodomys ordii	78.36	0.00e+00	655.00
IUUC-Ete-032807	Echinops telfairi	83.25	0.00e+00	685.00
IUUC-Eca-033479	Equus caballus	91.90	0.00e+00	1447.00
IUUC-Eeu-034835	Erinaceus europaeus	83.64	0.00e+00	659.00
IUUC-Fca-036320	Felis catus	92.02	0.00e+00	1466.00
IUUC-Fal-037029	Ficedula albicollis	60.95	0.00e+00	854.00
IUUC-Gmo-039480	Gadus morhua	53.07	1.00e-114	407.00
IUUC-Gga-040527	Gallus gallus	63.60	0.00e+00	915.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.49	3.00e-113	403.00
IUUC-Gma-043919	Glycine max	27.41	3.00e-30	127.00
IUUC-Ggo-045598	Gorilla gorilla	98.91	0.00e+00	1566.00
IUUC-Hvu-047146	Hordeum vulgare	35.38	2.00e-26	115.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	91.66	0.00e+00	1446.00
IUUC-Lch-050536	Latimeria chalumnae	53.08	0.00e+00	749.00
IUUC-Lpe-050703	Leersia perrieri	29.01	6.00e-27	116.00
IUUC-Loc-051814	Lepisosteus oculatus	57.00	4.00e-126	446.00
IUUC-Laf-053732	Loxodonta africana	86.51	0.00e+00	1394.00
IUUC-Mcc-054661	Macaca mulatta	98.18	0.00e+00	1556.00
IUUC-Meu-055967	Macropus eugenii	73.35	9.00e-159	554.00
IUUC-Mga-059551	Meleagris gallopavo	63.72	0.00e+00	928.00
IUUC-Mvi-060391	Microbotryum violaceum	32.31	3.00e-19	90.90
IUUC-Mmr-061747	Microcebus murinus	93.43	0.00e+00	1437.00
IUUC-Mdo-062220	Monodelphis domestica	69.17	0.00e+00	1051.00
IUUC-Mmu-063582	Mus musculus	82.73	0.00e+00	1268.00
IUUC-Mac-064941	Musa acuminata	32.72	7.00e-37	149.00
IUUC-Mpu-066339	Mustela putorius furo	91.29	0.00e+00	1454.00
IUUC-Mlu-067511	Myotis lucifugus	85.85	0.00e+00	1337.00
IUUC-Nle-069252	Nomascus leucogenys	98.18	0.00e+00	1554.00
IUUC-Opr-070969	Ochotona princeps	86.21	0.00e+00	1308.00
IUUC-Ont-071786	Oreochromis niloticus	51.76	7.00e-118	418.00
IUUC-Ocu-074704	Oryctolagus cuniculus	91.22	0.00e+00	1405.00
IUUC-Oba-075094	Oryza barthii	29.22	2.00e-29	125.00
IUUC-Obr-076743	Oryza brachyantha	30.25	9.00e-30	125.00
IUUC-Ogl-077739	Oryza glaberrima	29.22	2.00e-29	124.00
IUUC-Ogu-078851	Oryza glumaepatula	29.22	2.00e-29	125.00
IUUC-Oin-079402	Oryza indica	29.22	2.00e-29	124.00
IUUC-Olo-080431	Oryza longistaminata	29.22	2.00e-29	125.00
IUUC-Ome-081580	Oryza meridionalis	29.22	2.00e-29	125.00
IUUC-Oni-082644	Oryza nivara	29.22	2.00e-29	124.00
IUUC-Opu-083452	Oryza punctata	28.79	6.00e-29	123.00
IUUC-Oru-084546	Oryza rufipogon	29.22	2.00e-29	124.00
IUUC-Osa-085858	Oryza sativa	29.22	2.00e-29	125.00
IUUC-Oga-088713	Otolemur garnettii	91.17	0.00e+00	1442.00
IUUC-Oar-089887	Ovis aries	91.29	0.00e+00	1414.00
IUUC-Ptr-091670	Pan troglodytes	98.79	0.00e+00	1566.00
IUUC-Pan-092293	Papio anubis	98.18	0.00e+00	1556.00
IUUC-Psi-093101	Pelodiscus sinensis	66.63	0.00e+00	948.00
IUUC-Ppa-095584	Physcomitrella patens	29.33	3.00e-34	141.00
IUUC-Pfo-097202	Poecilia formosa	53.44	4.00e-118	419.00
IUUC-Pab-098773	Pongo abelii	98.29	0.00e+00	1217.00
IUUC-Pop-099136	Populus trichocarpa	29.46	1.00e-37	151.00
IUUC-Pca-101069	Procavia capensis	68.69	0.00e+00	1130.00
IUUC-Ppe-101794	Prunus persica	30.32	5.00e-33	136.00
IUUC-Pva-103092	Pteropus vampyrus	88.53	0.00e+00	683.00
IUUC-Rno-105237	Rattus norvegicus	83.21	0.00e+00	1277.00
IUUC-Sha-106889	Sarcophilus harrisii	72.79	0.00e+00	1114.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	27.62	3.00e-12	67.00
IUUC-Sit-110283	Setaria italica	32.07	8.00e-30	126.00
IUUC-Sly-111487	Solanum lycopersicum	30.49	1.00e-38	155.00
IUUC-Stu-112820	Solanum tuberosum	29.05	1.00e-36	148.00
IUUC-Sar-113530	Sorex araneus	83.09	0.00e+00	1306.00
IUUC-Sbi-113785	Sorghum bicolor	38.31	1.00e-24	108.00
IUUC-Ssc-116091	Sus scrofa	90.61	0.00e+00	1389.00
IUUC-Tgu-117478	Taeniopygia guttata	60.05	0.00e+00	874.00
IUUC-Tru-118640	Takifugu rubripes	53.40	7.00e-119	421.00
IUUC-Tsy-119042	Tarsius syrichta	79.66	0.00e+00	926.00
IUUC-Tni-120015	Tetraodon nigroviridis	47.36	0.00e+00	629.00
IUUC-Tca-121701	Theobroma cacao	27.66	3.00e-36	147.00
IUUC-Tae-125305	Triticum aestivum	28.40	2.00e-25	111.00
IUUC-Tur-126788	Triticum urartu	28.40	8.00e-26	112.00
IUUC-Tbe-127309	Tupaia belangeri	77.92	0.00e+00	1113.00
IUUC-Ttr-128271	Tursiops truncatus	91.04	0.00e+00	1439.00
IUUC-Vpa-130674	Vicugna pacos	91.25	0.00e+00	1330.00
IUUC-Xtr-131869	Xenopus tropicalis	52.21	0.00e+00	784.00
IUUC-Xma-134195	Xiphophorus maculatus	53.21	2.00e-116	413.00
IUUC-Zma-135157	Zea mays	30.56	3.00e-27	117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence