iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092023

Ensembl Protein ID

ENSPANP00000016700.1

UniProt Accession

A0A096NUH6; A0A096NUH6_PAPAN

Genbank Protein ID

ENSPANP00000016700

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHZZ01007539

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000018342.1	ENSPANT00000015109.1	ENSPANP00000016700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-86	288.0	192	813

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprell 74
           G++NlgNtC++N+v+Q L+++  l++l++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+
   Q: 192  GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPSVLF 277
           9*****************************542..333222.23445566666777777777*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
           ++l+++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+
   Q: 278  NQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCE 366
           *********************************99888888888888877777773443335555555555****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec+n+s+ ++pf+d+slp+ +++ +k++                                                             
   Q: 367  ECANISTVKDPFIDISLPIIEERVSKPLllgkmnkyrslretdhdryngnvtvenihqpraakkhssskdksqlihdrkcirklsgetv 455
           ***********************99888************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  vtyqkkenlemngdslmfarlmnsesplnesptddsekeashsesnvdadseasesesaskqtelfrsssgsgvhtdgplyppsagelv 544
           ***************************************************************************************** PP
   S: 186  ...........................................................................slqdcLesftkeee 199
                                                                                      s+q+cL +ft+ e 
   Q: 545  ytketdsgdkqmaeaiselhlrstvtghqdfdrenqplsisnnlcflegkhlrphspqnafqtlsqtyittskecSVQSCLYQFTSMEL 633
           ***************************************************************************************** PP
   S: 200  legenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           l g+nk+ ce+c+k+++                   a+k+l ++ +P vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++
   Q: 634  LMGNNKLLCENCTKNKQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATC 720
           *************88888999999999999999999*********************..9999************************88 PP
   S: 270  ekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgsta 330
           ++ +   k+ Y L+++v HsGs+++GHY+ayvk                           + g+W++++D++V++v+e++ l+   ++a
   Q: 721  KNASMgdKVLYGLYGIVEHSGSMREGHYTAYVKVrtpsrklsehptkkksvpglkeadseSAGQWVHVSDTYVQVVPESRALS---AQA 806
           77655669**************************999999999999999999999888877888*******************...*** PP
   S: 331  YvlfYkr 337
           Y+lfY+r
   Q: 807  YLLFYER 813
           *****98 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MRVKDPSKAL PEKAKRSKRP TVPHEEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQPVLPS DIWLCLKCGF QGCGKNSESQ HSLKHFKNSR IEPHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AAGATCCAAG TAAAGCTTTA CCTGAGAAAG CCAAAAGAAG TAAAAGGCCT 60
ACTGTACCTC ATGAAGAAGA CTCTTCAGAT GATATTGCTG GTAAATTGTG ATATTTGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	72.87	0.00e+00	1082.00
IUUC-Apl-003512	Anas platyrhynchos	67.11	0.00e+00	1042.00
IUUC-Aca-004284	Anolis carolinensis	60.36	0.00e+00	947.00
IUUC-Ame-010735	Astyanax mexicanus	60.69	8.00e-86	310.00
IUUC-Bta-012880	Bos taurus	81.81	0.00e+00	1268.00
IUUC-Cja-019144	Callithrix jacchus	92.16	0.00e+00	1502.00
IUUC-Cfa-020971	Canis familiaris	82.67	0.00e+00	730.00
IUUC-Cpo-022497	Cavia porcellus	69.60	0.00e+00	1080.00
IUUC-Csa-023910	Chlorocebus sabaeus	98.32	0.00e+00	1514.00
IUUC-Cho-024358	Choloepus hoffmanni	61.90	8.00e-112	397.00
IUUC-Dre-028106	Danio rerio	53.35	0.00e+00	795.00
IUUC-Dno-029456	Dasypus novemcinctus	76.13	0.00e+00	700.00
IUUC-Dor-030438	Dipodomys ordii	64.38	0.00e+00	939.00
IUUC-Dme-031870	Drosophila melanogaster	47.31	2.00e-35	145.00
IUUC-Ete-032736	Echinops telfairi	64.72	0.00e+00	940.00
IUUC-Eca-034211	Equus caballus	82.17	0.00e+00	1319.00
IUUC-Eeu-034797	Erinaceus europaeus	81.56	8.00e-86	311.00
IUUC-Fca-035947	Felis catus	78.14	0.00e+00	1144.00
IUUC-Fal-037199	Ficedula albicollis	67.08	0.00e+00	920.00
IUUC-Gmo-039228	Gadus morhua	61.01	5.00e-141	494.00
IUUC-Gga-040823	Gallus gallus	63.26	1.00e-163	569.00
IUUC-Gac-042406	Gasterosteus aculeatus	59.52	2.00e-136	479.00
IUUC-Ggo-045402	Gorilla gorilla	94.98	0.00e+00	1550.00
IUUC-Hsa-046430	Homo sapiens	94.60	0.00e+00	1549.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	81.66	0.00e+00	746.00
IUUC-Lch-049547	Latimeria chalumnae	57.75	0.00e+00	892.00
IUUC-Loc-052842	Lepisosteus oculatus	58.17	0.00e+00	885.00
IUUC-Laf-053988	Loxodonta africana	81.95	0.00e+00	1324.00
IUUC-Mcc-055491	Macaca mulatta	93.74	0.00e+00	1526.00
IUUC-Meu-056256	Macropus eugenii	63.77	8.00e-171	593.00
IUUC-Mtr-057945	Medicago truncatula	31.58	3.00e-34	140.00
IUUC-Mla-059026	Melampsora laricipopulina	31.22	2.00e-16	80.90
IUUC-Mga-059833	Meleagris gallopavo	59.42	1.00e-163	569.00
IUUC-Mmr-060952	Microcebus murinus	84.60	0.00e+00	1331.00
IUUC-Mdo-062642	Monodelphis domestica	69.44	0.00e+00	1058.00
IUUC-Mmu-063945	Mus musculus	77.87	0.00e+00	1225.00
IUUC-Mpu-065944	Mustela putorius furo	75.18	0.00e+00	1152.00
IUUC-Mlu-067049	Myotis lucifugus	81.34	0.00e+00	1255.00
IUUC-Nle-069828	Nomascus leucogenys	94.49	0.00e+00	1541.00
IUUC-Opr-070672	Ochotona princeps	70.81	2.00e-143	502.00
IUUC-Ont-072121	Oreochromis niloticus	58.78	9.00e-133	467.00
IUUC-Oan-073656	Ornithorhynchus anatinus	63.48	0.00e+00	1003.00
IUUC-Ocu-074323	Oryctolagus cuniculus	81.54	0.00e+00	1263.00
IUUC-Ola-087238	Oryzias latipes	59.42	5.00e-147	514.00
IUUC-Oga-088379	Otolemur garnettii	77.60	0.00e+00	1238.00
IUUC-Oar-089718	Ovis aries	82.42	0.00e+00	1276.00
IUUC-Ptr-091358	Pan troglodytes	94.85	0.00e+00	1551.00
IUUC-Psi-093256	Pelodiscus sinensis	65.90	0.00e+00	967.00
IUUC-Ppa-095584	Physcomitrella patens	29.29	9.00e-36	145.00
IUUC-Pfo-097285	Poecilia formosa	51.72	4.00e-118	419.00
IUUC-Pab-098539	Pongo abelii	95.22	0.00e+00	1550.00
IUUC-Pop-099588	Populus trichocarpa	32.09	8.00e-34	139.00
IUUC-Pca-100610	Procavia capensis	67.22	0.00e+00	912.00
IUUC-Pva-102985	Pteropus vampyrus	90.27	0.00e+00	699.00
IUUC-Rno-105538	Rattus norvegicus	77.75	0.00e+00	1232.00
IUUC-Sha-107022	Sarcophilus harrisii	72.92	9.00e-179	620.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.21	1.00e-21	98.20
IUUC-Sar-113637	Sorex araneus	70.66	0.00e+00	1058.00
IUUC-Ssc-115870	Sus scrofa	81.17	0.00e+00	1308.00
IUUC-Tgu-116907	Taeniopygia guttata	67.76	0.00e+00	1055.00
IUUC-Tru-117835	Takifugu rubripes	51.23	1.00e-106	380.00
IUUC-Tsy-118869	Tarsius syrichta	77.70	0.00e+00	1207.00
IUUC-Tni-119716	Tetraodon nigroviridis	62.99	8.00e-92	331.00
IUUC-Tbe-128041	Tupaia belangeri	65.28	0.00e+00	942.00
IUUC-Ttr-128901	Tursiops truncatus	80.81	0.00e+00	1273.00
IUUC-Vpa-130331	Vicugna pacos	82.81	0.00e+00	1199.00
IUUC-Xtr-131794	Xenopus tropicalis	64.34	3.00e-143	502.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence