iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008713

Ensembl Protein ID

EED54915

UniProt Accession

B8N7E5; RSP5_ASPFN

Genbank Protein ID

EED54915.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

EQ963474

Gene Name

hulA; AFLA_021670

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_021670	EED54915	EED54915

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.90e-124	413.0	480	811

Active Site

Position(s)	Description	Evidence
780	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  +fyk++l+
   Q: 480  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLR 579
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+sl+d+e vd++l+++l++ ++n   die + ++ltf v++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++eq++af +Gfne+ip 
   Q: 580  KKVSLQDMEGVDEDLHRNLTWTLDN---DIEGI-IELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPA 676
           ***********************99...9***9.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw++++ +++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k++++  lP+
   Q: 677  DLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQESDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKSGDPGALPK 776
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+L+LP+Y++ ++l++kL +A+eet gF++
   Q: 777  SHTCFNRLDLPPYKTNDVLEHKLSIAVEETLGFGQ 811
           *********************************86 PP

Organism

Aspergillus flavus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MTCSQPNLRV TIIAADGLYK RDVFRFPDPF AVATVGGEQT HTTSVIKKTL NPYWNEMFDL 60
RVNEDSILAI QIFDQKKFKK KDQGFLGVIN VRIGDVIDLQ MGGDEMLTRD LKKSNDNLVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTTGCA GCCAGCCAAA CCTCAGGGTT ACAAGTAAGC CATTCGGGAA TGGGGGAGAA 60
CCATCAGTCA TTCTTCCATA CAGAAGAGAA GGGCAAAGAG CTTACTGACT CTCTTTCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

afv:AFLA_021670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	48.09	5.00e-157	546.00
IUUC-Apl-003893	Anas platyrhynchos	47.83	7.00e-154	536.00
IUUC-Aca-005338	Anolis carolinensis	47.31	1.00e-154	538.00
IUUC-Ago-007742	Ashbya gossypii	66.10	0.00e+00	1004.00
IUUC-Acl-008273	Aspergillus clavatus	93.84	0.00e+00	1466.00
IUUC-Afu-009103	Aspergillus fumigatus	90.29	0.00e+00	1414.00
IUUC-Ani-009259	Aspergillus nidulans	90.43	0.00e+00	1430.00
IUUC-Ang-009738	Aspergillus niger	94.23	0.00e+00	1467.00
IUUC-Aor-010053	Aspergillus oryzae	100.00	0.00e+00	627.00
IUUC-Ate-010529	Aspergillus terreus	95.18	0.00e+00	1496.00
IUUC-Ame-010810	Astyanax mexicanus	52.47	7.00e-146	509.00
IUUC-Bgr-012148	Blumeria graminis	73.00	0.00e+00	1102.00
IUUC-Bta-012679	Bos taurus	48.09	2.00e-157	547.00
IUUC-Bci-013785	Botrytis cinerea	74.23	0.00e+00	1168.00
IUUC-Cel-018299	Caenorhabditis elegans	45.71	5.00e-149	519.00
IUUC-Cja-018732	Callithrix jacchus	47.93	2.00e-157	548.00
IUUC-Cfa-021226	Canis familiaris	45.83	5.00e-157	546.00
IUUC-Cpo-021671	Cavia porcellus	48.09	2.00e-157	547.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.54	2.00e-153	534.00
IUUC-Cho-024695	Choloepus hoffmanni	47.64	2.00e-156	544.00
IUUC-Cin-025212	Ciona intestinalis	44.43	7.00e-142	496.00
IUUC-Csv-026256	Ciona savignyi	44.09	7.00e-143	498.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	73.09	0.00e+00	1118.00
IUUC-Cne-026849	Cryptococcus neoformans	62.70	0.00e+00	997.00
IUUC-Dre-027770	Danio rerio	52.47	2.00e-146	511.00
IUUC-Dno-029466	Dasypus novemcinctus	48.09	3.00e-157	547.00
IUUC-Dor-030138	Dipodomys ordii	47.26	3.00e-152	530.00
IUUC-Dse-031241	Dothistroma septosporum	75.21	0.00e+00	1204.00
IUUC-Dme-032041	Drosophila melanogaster	45.67	5.00e-143	499.00
IUUC-Ete-033145	Echinops telfairi	45.44	3.00e-145	507.00
IUUC-Eca-033445	Equus caballus	48.09	7.00e-157	545.00
IUUC-Eeu-035247	Erinaceus europaeus	48.09	4.00e-157	546.00
IUUC-Fca-036384	Felis catus	48.31	7.00e-157	546.00
IUUC-Fal-037547	Ficedula albicollis	46.60	8.00e-151	525.00
IUUC-Fox-037774	Fusarium oxysporum	73.32	0.00e+00	1135.00
IUUC-Fso-038393	Fusarium solani	72.40	0.00e+00	1100.00
IUUC-Gmo-039674	Gadus morhua	46.91	6.00e-152	529.00
IUUC-Ggr-040107	Gaeumannomyces graminis	71.81	0.00e+00	1144.00
IUUC-Gga-041276	Gallus gallus	47.94	2.00e-154	537.00
IUUC-Gac-042020	Gasterosteus aculeatus	47.49	1.00e-154	538.00
IUUC-Ggo-045332	Gorilla gorilla	48.09	6.00e-157	546.00
IUUC-Hsa-045968	Homo sapiens	48.09	3.00e-157	547.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	47.32	2.00e-155	541.00
IUUC-Kpa-049273	Komagataella pastoris	66.99	0.00e+00	1044.00
IUUC-Lch-050443	Latimeria chalumnae	47.76	2.00e-155	541.00
IUUC-Loc-052662	Lepisosteus oculatus	47.16	2.00e-145	508.00
IUUC-Lma-052980	Leptosphaeria maculans	73.08	0.00e+00	698.00
IUUC-Laf-053850	Loxodonta africana	48.09	7.00e-157	546.00
IUUC-Mcc-055821	Macaca mulatta	48.09	4.00e-157	546.00
IUUC-Meu-055953	Macropus eugenii	39.87	2.00e-116	411.00
IUUC-Mor-057097	Magnaporthe oryzae	73.28	0.00e+00	1155.00
IUUC-Mpo-057442	Magnaporthe poae	69.75	0.00e+00	1024.00
IUUC-Mla-058996	Melampsora laricipopulina	69.68	0.00e+00	858.00
IUUC-Mga-059362	Meleagris gallopavo	46.57	2.00e-151	527.00
IUUC-Mvi-060395	Microbotryum violaceum	78.79	0.00e+00	818.00
IUUC-Mmr-061061	Microcebus murinus	47.62	1.00e-159	555.00
IUUC-Mdo-062173	Monodelphis domestica	44.25	7.00e-153	532.00
IUUC-Mmu-064136	Mus musculus	48.09	5.00e-157	546.00
IUUC-Mpu-066765	Mustela putorius furo	48.09	6.00e-157	546.00
IUUC-Mlu-067565	Myotis lucifugus	48.09	8.00e-157	545.00
IUUC-Nfi-068427	Neosartorya fischeri	93.21	0.00e+00	1444.00
IUUC-Ncr-068918	Neurospora crassa	72.95	0.00e+00	1099.00
IUUC-Nle-069225	Nomascus leucogenys	48.13	6.00e-158	550.00
IUUC-Opr-071044	Ochotona princeps	48.09	7.00e-157	546.00
IUUC-Ont-071664	Oreochromis niloticus	46.26	3.00e-144	504.00
IUUC-Oan-073019	Ornithorhynchus anatinus	45.92	3.00e-149	520.00
IUUC-Ocu-074160	Oryctolagus cuniculus	47.85	7.00e-157	546.00
IUUC-Ola-087467	Oryzias latipes	47.51	3.00e-154	537.00
IUUC-Oga-088460	Otolemur garnettii	48.09	4.00e-157	546.00
IUUC-Oar-090198	Ovis aries	48.18	7.00e-157	546.00
IUUC-Ptr-090939	Pan troglodytes	48.09	3.00e-157	547.00
IUUC-Pan-092284	Papio anubis	48.09	3.00e-157	547.00
IUUC-Psi-093645	Pelodiscus sinensis	47.67	1.00e-155	541.00
IUUC-Pma-094364	Petromyzon marinus	52.05	1.00e-142	498.00
IUUC-Pno-095118	Phaeosphaeria nodorum	74.04	0.00e+00	1187.00
IUUC-Pfo-097145	Poecilia formosa	47.71	4.00e-150	523.00
IUUC-Pab-098088	Pongo abelii	48.09	3.00e-157	547.00
IUUC-Pca-100568	Procavia capensis	45.42	3.00e-137	481.00
IUUC-Pva-102354	Pteropus vampyrus	48.09	1.00e-156	545.00
IUUC-Pgr-103620	Puccinia graminis	77.96	0.00e+00	800.00
IUUC-Ptt-103806	Puccinia triticina	78.54	0.00e+00	689.00
IUUC-Pte-104016	Pyrenophora teres	75.69	0.00e+00	1195.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.69	0.00e+00	1195.00
IUUC-Rno-105318	Rattus norvegicus	48.09	4.00e-157	546.00
IUUC-Sce-106289	Saccharomyces cerevisiae	75.08	0.00e+00	917.00
IUUC-Sha-107482	Sarcophilus harrisii	45.17	6.00e-156	542.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	65.43	0.00e+00	1034.00
IUUC-Spo-108171	Schizosaccharomyces pombe	67.83	0.00e+00	1041.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	74.51	0.00e+00	1167.00
IUUC-Stu-112894	Solanum tuberosum	34.34	4.00e-56	211.00
IUUC-Sar-113761	Sorex araneus	47.14	1.00e-154	538.00
IUUC-Sre-114929	Sporisorium reilianum	70.78	0.00e+00	869.00
IUUC-Ssc-115368	Sus scrofa	45.98	7.00e-149	519.00
IUUC-Tgu-117130	Taeniopygia guttata	47.85	2.00e-154	538.00
IUUC-Tru-118610	Takifugu rubripes	54.12	4.00e-153	533.00
IUUC-Tsy-119492	Tarsius syrichta	48.26	2.00e-155	540.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.23	4.00e-149	520.00
IUUC-Tre-122203	Trichoderma reesei	72.95	0.00e+00	1106.00
IUUC-Tvi-122595	Trichoderma virens	72.21	0.00e+00	1123.00
IUUC-Tme-126897	Tuber melanosporum	71.11	0.00e+00	1083.00
IUUC-Tbe-127408	Tupaia belangeri	44.74	5.00e-134	470.00
IUUC-Ttr-128235	Tursiops truncatus	53.09	2.00e-147	514.00
IUUC-Uma-129332	Ustilago maydis	70.95	0.00e+00	836.00
IUUC-Vda-129753	Verticillium dahliae	70.42	0.00e+00	1068.00
IUUC-Vpa-130503	Vicugna pacos	50.31	1.00e-137	482.00
IUUC-Xtr-132859	Xenopus tropicalis	47.76	1.00e-156	545.00
IUUC-Xma-133797	Xiphophorus maculatus	48.17	1.00e-157	548.00
IUUC-Yli-134668	Yarrowia lipolytica	74.12	0.00e+00	936.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence