iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003310

Ensembl Protein ID

ENSAPLP00000001881.1

UniProt Accession

U3I3R0; U3I3R0_ANAPL

Genbank Protein ID

ENSAPLP00000001881

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ADON01052709

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000002071.1	ENSAPLT00000002459.1	ENSAPLP00000001881.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.30e-135	449.4	592	924

Active Site

Position(s)	Description	Evidence
893	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 592  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 679
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee++l++ f+v+ e+lg+++++eLk+gG+ni Vt+eNkeeY+ l++e
   Q: 680  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECNLEMYFCVDMELLGKVTSHELKSGGSNILVTEENKEEYIGLMAE 765
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l +F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 766  WRFSRGVREQTKAFLDGFNEVVPLQWLHYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 853
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 854  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 924
           *********************************************************************96 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MATASPRSDT SNNHNGRLQM QVTVSSAKLK RKKNWFGTTF YTELTADGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LRQALEIHNR KLEKVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACAG CCTCACCAAG ATCTGATACA AGTAACAACC ATAATGGCAG GTTACAGATG 60
CAAGTAACAG GCAAGTAGTG ATTTTTGTCA TGGTGATTTT TACTGTGAAA TATACATATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	84.16	0.00e+00	1571.00
IUUC-Aca-005388	Anolis carolinensis	84.90	0.00e+00	1554.00
IUUC-Bta-012857	Bos taurus	83.93	0.00e+00	1555.00
IUUC-Cel-018299	Caenorhabditis elegans	68.05	0.00e+00	850.00
IUUC-Cja-019448	Callithrix jacchus	84.18	0.00e+00	1581.00
IUUC-Cfa-020728	Canis familiaris	84.27	0.00e+00	1560.00
IUUC-Cpo-021635	Cavia porcellus	80.15	0.00e+00	1521.00
IUUC-Csa-023805	Chlorocebus sabaeus	86.54	0.00e+00	1201.00
IUUC-Cho-024943	Choloepus hoffmanni	73.40	0.00e+00	1034.00
IUUC-Cin-025212	Ciona intestinalis	74.09	0.00e+00	915.00
IUUC-Csv-026256	Ciona savignyi	73.18	0.00e+00	909.00
IUUC-Dre-028245	Danio rerio	73.95	0.00e+00	1256.00
IUUC-Dno-029618	Dasypus novemcinctus	83.75	0.00e+00	1563.00
IUUC-Dme-032041	Drosophila melanogaster	71.55	0.00e+00	898.00
IUUC-Ete-032779	Echinops telfairi	91.73	0.00e+00	1081.00
IUUC-Eca-033313	Equus caballus	83.30	0.00e+00	1536.00
IUUC-Eeu-035259	Erinaceus europaeus	75.86	0.00e+00	1383.00
IUUC-Fca-035420	Felis catus	83.30	0.00e+00	1558.00
IUUC-Fal-037335	Ficedula albicollis	95.36	0.00e+00	1759.00
IUUC-Gmo-039172	Gadus morhua	88.01	0.00e+00	1070.00
IUUC-Gga-040246	Gallus gallus	95.89	0.00e+00	1754.00
IUUC-Gac-042211	Gasterosteus aculeatus	92.48	0.00e+00	1184.00
IUUC-Ggo-045001	Gorilla gorilla	83.50	0.00e+00	1387.00
IUUC-Hsa-046544	Homo sapiens	83.85	0.00e+00	1578.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	82.60	0.00e+00	1523.00
IUUC-Lch-050398	Latimeria chalumnae	78.69	0.00e+00	1424.00
IUUC-Loc-052116	Lepisosteus oculatus	76.96	0.00e+00	1424.00
IUUC-Laf-053551	Loxodonta africana	83.23	0.00e+00	1535.00
IUUC-Mga-059986	Meleagris gallopavo	95.46	0.00e+00	1781.00
IUUC-Mmr-060945	Microcebus murinus	80.97	0.00e+00	1498.00
IUUC-Mdo-063024	Monodelphis domestica	82.46	0.00e+00	1501.00
IUUC-Mmu-063202	Mus musculus	81.49	0.00e+00	1489.00
IUUC-Mpu-065773	Mustela putorius furo	84.30	0.00e+00	1559.00
IUUC-Mlu-067373	Myotis lucifugus	93.57	0.00e+00	632.00
IUUC-Nle-069188	Nomascus leucogenys	84.18	0.00e+00	1580.00
IUUC-Opr-070965	Ochotona princeps	80.60	0.00e+00	1483.00
IUUC-Ont-072226	Oreochromis niloticus	90.41	0.00e+00	1189.00
IUUC-Oan-073497	Ornithorhynchus anatinus	86.75	0.00e+00	1568.00
IUUC-Ocu-073891	Oryctolagus cuniculus	80.06	0.00e+00	1465.00
IUUC-Ola-087438	Oryzias latipes	89.98	0.00e+00	1183.00
IUUC-Oga-087922	Otolemur garnettii	83.24	0.00e+00	1545.00
IUUC-Oar-089317	Ovis aries	83.64	0.00e+00	1538.00
IUUC-Ptr-090484	Pan troglodytes	83.75	0.00e+00	1576.00
IUUC-Pan-092117	Papio anubis	83.64	0.00e+00	1573.00
IUUC-Psi-093338	Pelodiscus sinensis	90.60	0.00e+00	1690.00
IUUC-Pma-094279	Petromyzon marinus	74.26	0.00e+00	840.00
IUUC-Pfo-096171	Poecilia formosa	93.65	0.00e+00	1187.00
IUUC-Pab-098654	Pongo abelii	84.23	0.00e+00	1163.00
IUUC-Pva-102811	Pteropus vampyrus	74.65	0.00e+00	1340.00
IUUC-Rno-106125	Rattus norvegicus	81.70	0.00e+00	1500.00
IUUC-Sha-107243	Sarcophilus harrisii	84.66	0.00e+00	1558.00
IUUC-Ssc-115368	Sus scrofa	83.55	0.00e+00	1543.00
IUUC-Tgu-117079	Taeniopygia guttata	95.46	0.00e+00	1723.00
IUUC-Tru-118062	Takifugu rubripes	72.23	0.00e+00	1374.00
IUUC-Tsy-119507	Tarsius syrichta	78.79	0.00e+00	1449.00
IUUC-Tni-120151	Tetraodon nigroviridis	90.68	0.00e+00	1176.00
IUUC-Ttr-129260	Tursiops truncatus	74.03	0.00e+00	1318.00
IUUC-Xtr-132877	Xenopus tropicalis	71.87	0.00e+00	1248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence