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Tag Content
UUCD2 ID IUUC-Gga-040617
UUCD1 version UUC-GaG-00636
Ensembl Protein ID ENSGALP00000000989.4
UniProt Accession E1C3L4; E1C3L4_CHICK
Genbank Protein ID ENSGALP00000000989
Protein Name Uncharacterized protein
Genbank Nucleotide ID AADN04000244
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000000699.5 ENSGALT00000000991.4 ENSGALP00000000989.4
ENSGALG00000000699.5 ENSGALT00000077253.1 ENSGALP00000049801.1
ENSGALG00000000699.5 ENSGALT00000055498.1 ENSGALP00000049054.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 8.10e-136 453.2 591 923
Active Site
Position(s) Description Evidence
892 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 591  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 678
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 679  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 764
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 765  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 852
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 853  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 923
           *********************************************************************96 PP
   
Organism Gallus gallus
Protein Sequence
(Fasta)
MASASSSRAR AGLPCEKSQL SVKVVSVKPK AHSRQSRMNC YVEVAGDGLP SETKKTGKQM 60
GSSELLWNEI LILNVTAQSH LDLKVWSCHT LRNELLGTAS VSLWNLLKNG GKLENKQLTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040617|E3,HECT|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAACGGAG CGGCTGCCGG TGAGGTGGGT GAGGGCCGGG CGGTGTGGAG CGGCGCGGTC 60
TGGCGGGGGG TTCTGGCGGT CGCGAGTGCG GGGAGCTGTT TCGTTTCGTT CCGTTCCGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040617|E3,HECT|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 79.69 0.00e+00 1444.00
IUUC-Apl-003912 Anas platyrhynchos 74.04 0.00e+00 1258.00
IUUC-Aca-004291 Anolis carolinensis 76.55 0.00e+00 1413.00
IUUC-Bta-013231 Bos taurus 79.45 0.00e+00 1426.00
IUUC-Cja-019455 Callithrix jacchus 79.98 0.00e+00 1471.00
IUUC-Cfa-021017 Canis familiaris 79.54 0.00e+00 1439.00
IUUC-Cpo-021988 Cavia porcellus 79.54 0.00e+00 1457.00
IUUC-Csa-023549 Chlorocebus sabaeus 79.87 0.00e+00 1470.00
IUUC-Dre-028513 Danio rerio 93.17 0.00e+00 1155.00
IUUC-Dno-028976 Dasypus novemcinctus 81.00 0.00e+00 1466.00
IUUC-Dor-030176 Dipodomys ordii 75.47 0.00e+00 1300.00
IUUC-Eca-033949 Equus caballus 80.31 0.00e+00 1454.00
IUUC-Eeu-034529 Erinaceus europaeus 82.83 0.00e+00 1052.00
IUUC-Fca-036236 Felis catus 79.98 0.00e+00 1465.00
IUUC-Fal-036948 Ficedula albicollis 85.36 0.00e+00 1459.00
IUUC-Gmo-038842 Gadus morhua 89.95 0.00e+00 1079.00
IUUC-Gac-041338 Gasterosteus aculeatus 72.30 0.00e+00 1300.00
IUUC-Ggo-045278 Gorilla gorilla 80.09 0.00e+00 1479.00
IUUC-Hsa-046148 Homo sapiens 80.09 0.00e+00 1480.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 95.52 0.00e+00 1093.00
IUUC-Lch-050663 Latimeria chalumnae 73.95 0.00e+00 1365.00
IUUC-Loc-052604 Lepisosteus oculatus 72.84 0.00e+00 1312.00
IUUC-Laf-053944 Loxodonta africana 80.09 0.00e+00 1464.00
IUUC-Mcc-055655 Macaca mulatta 79.87 0.00e+00 1474.00
IUUC-Meu-055953 Macropus eugenii 71.40 0.00e+00 1278.00
IUUC-Mga-060190 Meleagris gallopavo 96.71 0.00e+00 1744.00
IUUC-Mmr-060896 Microcebus murinus 79.87 0.00e+00 1455.00
IUUC-Mdo-062536 Monodelphis domestica 81.11 0.00e+00 1504.00
IUUC-Mmu-064017 Mus musculus 80.22 0.00e+00 1454.00
IUUC-Mpu-066608 Mustela putorius furo 77.62 0.00e+00 1387.00
IUUC-Mlu-067623 Myotis lucifugus 79.15 0.00e+00 1409.00
IUUC-Nle-069496 Nomascus leucogenys 78.23 0.00e+00 1431.00
IUUC-Opr-071054 Ochotona princeps 95.59 0.00e+00 1161.00
IUUC-Ont-071279 Oreochromis niloticus 89.20 0.00e+00 1117.00
IUUC-Oan-073512 Ornithorhynchus anatinus 78.38 0.00e+00 1417.00
IUUC-Ocu-074271 Oryctolagus cuniculus 79.93 0.00e+00 1436.00
IUUC-Ola-087237 Oryzias latipes 71.77 0.00e+00 1277.00
IUUC-Oga-088164 Otolemur garnettii 80.57 0.00e+00 1460.00
IUUC-Oar-089698 Ovis aries 79.65 0.00e+00 1431.00
IUUC-Ptr-091306 Pan troglodytes 78.77 0.00e+00 1447.00
IUUC-Pan-092814 Papio anubis 76.64 0.00e+00 1384.00
IUUC-Pfo-096709 Poecilia formosa 70.59 0.00e+00 1256.00
IUUC-Pab-098494 Pongo abelii 79.26 0.00e+00 1444.00
IUUC-Pca-100596 Procavia capensis 77.81 0.00e+00 1075.00
IUUC-Pva-103154 Pteropus vampyrus 74.35 0.00e+00 1314.00
IUUC-Rno-104954 Rattus norvegicus 79.31 0.00e+00 1275.00
IUUC-Sha-106781 Sarcophilus harrisii 80.90 0.00e+00 1509.00
IUUC-Ssc-116307 Sus scrofa 77.68 0.00e+00 1366.00
IUUC-Tgu-116530 Taeniopygia guttata 81.23 0.00e+00 1264.00
IUUC-Tru-118287 Takifugu rubripes 91.21 0.00e+00 1092.00
IUUC-Tni-120801 Tetraodon nigroviridis 70.10 0.00e+00 1224.00
IUUC-Tbe-127793 Tupaia belangeri 76.57 0.00e+00 1097.00
IUUC-Ttr-128275 Tursiops truncatus 83.94 0.00e+00 1189.00
IUUC-Uma-129332 Ustilago maydis 46.11 1.00e-142 500.00
IUUC-Xtr-132866 Xenopus tropicalis 84.69 0.00e+00 1136.00
Created Date 25-Jun-2017

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