iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033924

Ensembl Protein ID

ENSECAP00000018618.1

UniProt Accession

F6URD5; F6URD5_HORSE

Protein Name

Uncharacterized protein

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021091.1	ENSECAT00000022523.1	ENSECAP00000018618.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.20e-07	30.9	70	129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw...............pglknssskefrCPlC 45
           C+iCl  +++  + +pCgH f++ C+ + +               p ++   + + +CP C
   Q: 70   CPICLMALRE-AVQTPCGHRFCKACIiKSIrdaghkcppdeilyhPASSLTRRESLLCPMC 129
           ********88.888***********97666889999999999999899999999999**99 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MSLLNCENSC GSSQTESDCC AAMASSCSAA AKDDSVSGTA STGNLSSSFM EDIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPPDEI LYHPASSLTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AAATAGCTGT GGATCCAGCC AGACTGAAAG TGACTGCTGT 60
GCAGCCATGG CCAGCTCCTG TAGTGCTGCG GCAAAAGACG ACAGCGTGAG TGGAACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	89.50	0.00e+00	915.00
IUUC-Apl-004062	Anas platyrhynchos	69.98	0.00e+00	757.00
IUUC-Aca-004636	Anolis carolinensis	67.27	0.00e+00	703.00
IUUC-Ame-011682	Astyanax mexicanus	51.17	1.00e-142	499.00
IUUC-Bta-012692	Bos taurus	86.03	0.00e+00	918.00
IUUC-Cja-019426	Callithrix jacchus	85.27	0.00e+00	889.00
IUUC-Cfa-020948	Canis familiaris	87.58	0.00e+00	797.00
IUUC-Cpo-021378	Cavia porcellus	86.42	0.00e+00	911.00
IUUC-Csa-024045	Chlorocebus sabaeus	85.08	0.00e+00	899.00
IUUC-Cho-024973	Choloepus hoffmanni	67.72	4.00e-80	291.00
IUUC-Csv-026300	Ciona savignyi	36.40	2.00e-33	135.00
IUUC-Dre-027557	Danio rerio	54.44	8.00e-153	533.00
IUUC-Dno-030032	Dasypus novemcinctus	82.93	3.00e-132	464.00
IUUC-Dor-030790	Dipodomys ordii	85.64	0.00e+00	898.00
IUUC-Dme-031921	Drosophila melanogaster	25.16	7.00e-32	131.00
IUUC-Ete-032952	Echinops telfairi	72.93	0.00e+00	716.00
IUUC-Eeu-034734	Erinaceus europaeus	78.45	0.00e+00	792.00
IUUC-Fca-036222	Felis catus	81.22	0.00e+00	798.00
IUUC-Fal-036834	Ficedula albicollis	70.61	0.00e+00	679.00
IUUC-Gmo-039061	Gadus morhua	62.90	4.00e-69	255.00
IUUC-Gga-040599	Gallus gallus	70.75	0.00e+00	762.00
IUUC-Gac-041977	Gasterosteus aculeatus	51.55	3.00e-147	514.00
IUUC-Ggo-044508	Gorilla gorilla	80.18	0.00e+00	823.00
IUUC-Hsa-046349	Homo sapiens	85.27	0.00e+00	905.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	85.45	0.00e+00	888.00
IUUC-Lch-049821	Latimeria chalumnae	63.10	0.00e+00	671.00
IUUC-Lpe-051025	Leersia perrieri	24.69	1.00e-05	44.30
IUUC-Loc-051995	Lepisosteus oculatus	56.49	4.00e-163	567.00
IUUC-Laf-054115	Loxodonta africana	83.61	0.00e+00	904.00
IUUC-Mcc-055298	Macaca mulatta	85.08	0.00e+00	896.00
IUUC-Mga-059340	Meleagris gallopavo	70.75	0.00e+00	761.00
IUUC-Mmr-061063	Microcebus murinus	87.11	0.00e+00	903.00
IUUC-Mdo-062075	Monodelphis domestica	76.33	0.00e+00	827.00
IUUC-Mmu-063780	Mus musculus	82.50	0.00e+00	836.00
IUUC-Mac-064529	Musa acuminata	24.71	4.00e-11	62.00
IUUC-Mpu-065748	Mustela putorius furo	88.77	0.00e+00	917.00
IUUC-Mlu-067888	Myotis lucifugus	86.00	0.00e+00	898.00
IUUC-Nle-069234	Nomascus leucogenys	85.27	0.00e+00	902.00
IUUC-Opr-070393	Ochotona princeps	96.71	4.00e-123	434.00
IUUC-Ont-072459	Oreochromis niloticus	52.49	1.00e-152	533.00
IUUC-Oan-073578	Ornithorhynchus anatinus	79.12	0.00e+00	854.00
IUUC-Ocu-074201	Oryctolagus cuniculus	87.85	0.00e+00	917.00
IUUC-Ola-087319	Oryzias latipes	53.59	4.00e-67	249.00
IUUC-Olu-087748	Ostreococcus lucimarinus	21.85	3.00e-10	59.30
IUUC-Oga-087936	Otolemur garnettii	85.82	0.00e+00	898.00
IUUC-Oar-089379	Ovis aries	85.48	0.00e+00	921.00
IUUC-Ptr-090758	Pan troglodytes	85.64	0.00e+00	901.00
IUUC-Pan-092590	Papio anubis	84.90	0.00e+00	895.00
IUUC-Psi-093948	Pelodiscus sinensis	68.49	0.00e+00	743.00
IUUC-Pma-094434	Petromyzon marinus	40.37	2.00e-105	376.00
IUUC-Pfo-096912	Poecilia formosa	51.72	2.00e-146	512.00
IUUC-Pab-097651	Pongo abelii	85.64	0.00e+00	904.00
IUUC-Pop-099898	Populus trichocarpa	26.55	6.00e-08	51.60
IUUC-Pca-100958	Procavia capensis	85.28	0.00e+00	707.00
IUUC-Pva-103247	Pteropus vampyrus	82.28	3.00e-107	382.00
IUUC-Rno-104994	Rattus norvegicus	80.48	0.00e+00	845.00
IUUC-Sha-106494	Sarcophilus harrisii	77.16	0.00e+00	828.00
IUUC-Sar-113375	Sorex araneus	82.69	0.00e+00	868.00
IUUC-Sre-115218	Sporisorium reilianum	33.33	2.00e-09	57.40
IUUC-Ssc-115417	Sus scrofa	88.24	0.00e+00	947.00
IUUC-Tgu-117232	Taeniopygia guttata	70.20	0.00e+00	732.00
IUUC-Tru-118321	Takifugu rubripes	51.05	3.00e-146	511.00
IUUC-Tni-120475	Tetraodon nigroviridis	51.95	1.00e-144	506.00
IUUC-Tbe-127719	Tupaia belangeri	86.29	0.00e+00	697.00
IUUC-Ttr-129264	Tursiops truncatus	79.61	3.00e-102	365.00
IUUC-Vpa-130244	Vicugna pacos	80.00	1.00e-105	376.00
IUUC-Xtr-131948	Xenopus tropicalis	61.79	0.00e+00	665.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence