iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036222

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02034355

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000015652.3	ENSFCAT00000015656.3	ENSFCAP00000014515.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.60e-08	32.3	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + r++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCRACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC AAMASSCSAA AKDDSVSGTA STGNLSNSFM EETQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC RACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTCCGCGG CTGGGGCCGG GGCTCCGGGC GGCCCGGGGT CGCGGCCGAA GAGGCCTTCG 60
GGTGGAGAGA TTCGCGTGCA GGCAGTCTCA GCTCGGAGTG AGGAGTCTTG GCGGAGTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	88.54	0.00e+00	900.00
IUUC-Apl-004062	Anas platyrhynchos	69.38	0.00e+00	743.00
IUUC-Aca-004636	Anolis carolinensis	67.58	0.00e+00	701.00
IUUC-Ame-011682	Astyanax mexicanus	56.03	1.00e-164	572.00
IUUC-Bta-012692	Bos taurus	84.35	0.00e+00	895.00
IUUC-Cja-019426	Callithrix jacchus	81.55	0.00e+00	851.00
IUUC-Cfa-020948	Canis familiaris	86.12	0.00e+00	784.00
IUUC-Cpo-021378	Cavia porcellus	83.82	0.00e+00	874.00
IUUC-Csa-024045	Chlorocebus sabaeus	83.39	0.00e+00	867.00
IUUC-Cho-024973	Choloepus hoffmanni	62.90	6.00e-75	275.00
IUUC-Csv-026300	Ciona savignyi	37.56	4.00e-35	141.00
IUUC-Dre-027557	Danio rerio	56.40	3.00e-160	558.00
IUUC-Dno-030032	Dasypus novemcinctus	78.29	6.00e-121	426.00
IUUC-Dor-030790	Dipodomys ordii	83.39	0.00e+00	865.00
IUUC-Dme-031921	Drosophila melanogaster	28.29	7.00e-42	164.00
IUUC-Ete-032952	Echinops telfairi	84.37	7.00e-170	590.00
IUUC-Eca-033924	Equus caballus	78.71	0.00e+00	798.00
IUUC-Eeu-034734	Erinaceus europaeus	77.12	0.00e+00	780.00
IUUC-Fal-036834	Ficedula albicollis	66.80	0.00e+00	648.00
IUUC-Gmo-039061	Gadus morhua	58.87	6.00e-74	271.00
IUUC-Gga-040599	Gallus gallus	70.28	0.00e+00	755.00
IUUC-Gac-041977	Gasterosteus aculeatus	52.33	4.00e-151	528.00
IUUC-Ggo-044508	Gorilla gorilla	82.63	0.00e+00	878.00
IUUC-Hsa-046349	Homo sapiens	83.21	0.00e+00	874.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	82.29	0.00e+00	855.00
IUUC-Lch-049821	Latimeria chalumnae	64.90	0.00e+00	693.00
IUUC-Loc-051995	Lepisosteus oculatus	60.40	7.00e-172	597.00
IUUC-Laf-054115	Loxodonta africana	81.00	0.00e+00	872.00
IUUC-Mcc-055298	Macaca mulatta	83.39	0.00e+00	867.00
IUUC-Mga-059340	Meleagris gallopavo	70.09	0.00e+00	752.00
IUUC-Mvi-060553	Microbotryum violaceum	25.45	5.00e-14	72.40
IUUC-Mmr-061063	Microcebus murinus	84.32	0.00e+00	867.00
IUUC-Mdo-062075	Monodelphis domestica	75.09	0.00e+00	808.00
IUUC-Mmu-063780	Mus musculus	80.15	0.00e+00	803.00
IUUC-Mpu-065748	Mustela putorius furo	87.08	0.00e+00	891.00
IUUC-Mlu-067888	Myotis lucifugus	82.54	0.00e+00	861.00
IUUC-Nle-069234	Nomascus leucogenys	83.39	0.00e+00	870.00
IUUC-Opr-070393	Ochotona princeps	94.84	1.00e-121	429.00
IUUC-Ont-072459	Oreochromis niloticus	53.53	5.00e-156	544.00
IUUC-Oan-073578	Ornithorhynchus anatinus	80.00	0.00e+00	856.00
IUUC-Ocu-074201	Oryctolagus cuniculus	85.11	0.00e+00	881.00
IUUC-Ola-087319	Oryzias latipes	54.47	4.00e-68	252.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.51	2.00e-08	53.10
IUUC-Oga-087936	Otolemur garnettii	83.09	0.00e+00	858.00
IUUC-Oar-089379	Ovis aries	84.53	0.00e+00	909.00
IUUC-Ptr-090758	Pan troglodytes	83.58	0.00e+00	868.00
IUUC-Pan-092590	Papio anubis	83.58	0.00e+00	868.00
IUUC-Psi-093948	Pelodiscus sinensis	68.17	0.00e+00	740.00
IUUC-Pma-094434	Petromyzon marinus	42.57	8.00e-110	390.00
IUUC-Pfo-096912	Poecilia formosa	52.33	2.00e-148	518.00
IUUC-Pab-097651	Pongo abelii	83.58	0.00e+00	870.00
IUUC-Pca-100958	Procavia capensis	82.72	5.00e-177	613.00
IUUC-Pva-103247	Pteropus vampyrus	77.08	8.00e-97	347.00
IUUC-Rno-104994	Rattus norvegicus	79.04	0.00e+00	827.00
IUUC-Sha-106494	Sarcophilus harrisii	76.56	0.00e+00	827.00
IUUC-Sar-113375	Sorex araneus	81.35	0.00e+00	853.00
IUUC-Ssc-115417	Sus scrofa	84.13	0.00e+00	890.00
IUUC-Tgu-117232	Taeniopygia guttata	67.31	0.00e+00	710.00
IUUC-Tru-118321	Takifugu rubripes	51.69	4.00e-148	518.00
IUUC-Tni-120475	Tetraodon nigroviridis	53.22	3.00e-147	515.00
IUUC-Tbe-127719	Tupaia belangeri	87.61	3.00e-174	604.00
IUUC-Ttr-129264	Tursiops truncatus	74.41	2.00e-92	333.00
IUUC-Vpa-130244	Vicugna pacos	75.20	2.00e-97	349.00
IUUC-Xtr-131948	Xenopus tropicalis	61.92	0.00e+00	664.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence