iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094354

UUCD1 version

UUC-PeM-00426

Ensembl Protein ID

ENSPMAP00000005620.1

UniProt Accession

S4RK87; S4RK87_PETMA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000005071.1	ENSPMAT00000005641.1	ENSPMAP00000005620.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-96	323.2	424	741

Active Site

Position(s)	Description	Evidence
721	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           + dlkkrl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 424  PRDLKKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAI-NPEHLSYFHFVGRIMGMAVFHGHYIDG 511
           679********************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetk.eeeLkpgGenipVtneNkeeYvklvv 178
            ++ +fyk+llgk+++l d+e+vdpel+ksl +i++n   d++ l    + +v+++  g ++ +   + +G   ++  + ++ Yv    
   Q: 512  GFTLPFYKQLLGKPITLADMETVDPELHKSLVWILNNS--DVNIL---HEHTVHSCWGGRVQfCFRTVNKGVPAMIRLAPRRLYV---- 591
           ***********************************994..55554...2233334443333312224667888888888887665.... PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+ +gi+ q+ a+++Gfne+ip+ ll++F+e+elel+i G  +idv+d+k++t+ k+ +t++s++++wFw+++e+f++e r+++LqF
   Q: 592  SWRFLRGIEAQFLALQKGFNELIPQPLLKSFDEKELELIIGGLGKIDVSDWKSNTRLKH-CTPESSVVRWFWRAVESFDEERRARLLQF 679
           7********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLP..eYsskeilkek 322
           vTgssr+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++   +Y++ + ++++
   Q: 680  VTGSSRVPLQGFKALQgaagPRLFTIHLiDAKTDNLPKAHTCFNRIDITrnPYETNNNIYDR 741
           ****************************9*****************9953357777666666 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

MSNAVTRRNG ATKLRLTVLC AKNLAKKDFF RLPDPFAKIM VEGSGECHST DTVRNTLDPK 60
WNQHYDLYIS KSDSITISVW NRKKIHKKQG AGFLGCVRLL SNLISRIKDT GYQRLDLCRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGAGCGA GCGGGAGAGC GAGCGGGCGG CTTTGAGGCT TTTTCCCCTC GCGCCACAAA 60
CATGTCCAAC GCGGTCACGC GACGGAACGG TGCCACCAAG CTCCGACTTA CGGGTAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	74.57	0.00e+00	1118.00
IUUC-Apl-003513	Anas platyrhynchos	74.73	0.00e+00	1126.00
IUUC-Aca-005358	Anolis carolinensis	74.09	0.00e+00	1137.00
IUUC-Ame-011320	Astyanax mexicanus	71.37	0.00e+00	1110.00
IUUC-Bta-013399	Bos taurus	74.70	0.00e+00	1115.00
IUUC-Cja-019355	Callithrix jacchus	73.56	0.00e+00	1118.00
IUUC-Cfa-020568	Canis familiaris	64.92	0.00e+00	967.00
IUUC-Cpo-022200	Cavia porcellus	74.63	0.00e+00	1118.00
IUUC-Csa-024145	Chlorocebus sabaeus	67.81	0.00e+00	1009.00
IUUC-Cho-024963	Choloepus hoffmanni	59.44	6.00e-152	529.00
IUUC-Cin-025126	Ciona intestinalis	61.19	0.00e+00	867.00
IUUC-Csv-026339	Ciona savignyi	60.53	0.00e+00	909.00
IUUC-Dre-027650	Danio rerio	73.01	0.00e+00	1142.00
IUUC-Dno-029534	Dasypus novemcinctus	74.61	0.00e+00	1135.00
IUUC-Dme-031740	Drosophila melanogaster	63.59	2.00e-143	502.00
IUUC-Ete-032715	Echinops telfairi	70.38	0.00e+00	1033.00
IUUC-Eca-033580	Equus caballus	74.77	0.00e+00	1118.00
IUUC-Eeu-034945	Erinaceus europaeus	75.28	0.00e+00	1060.00
IUUC-Fca-035905	Felis catus	67.69	0.00e+00	981.00
IUUC-Fal-037275	Ficedula albicollis	74.20	0.00e+00	1123.00
IUUC-Gmo-039486	Gadus morhua	64.91	0.00e+00	657.00
IUUC-Gga-041060	Gallus gallus	70.89	0.00e+00	1068.00
IUUC-Gac-041295	Gasterosteus aculeatus	73.77	0.00e+00	1125.00
IUUC-Ggo-045408	Gorilla gorilla	59.97	0.00e+00	873.00
IUUC-Hsa-046726	Homo sapiens	74.48	0.00e+00	1133.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	76.17	0.00e+00	777.00
IUUC-Lch-050026	Latimeria chalumnae	73.40	0.00e+00	1135.00
IUUC-Loc-051760	Lepisosteus oculatus	70.82	0.00e+00	1092.00
IUUC-Lma-052980	Leptosphaeria maculans	40.05	4.00e-80	290.00
IUUC-Laf-053753	Loxodonta africana	74.73	0.00e+00	1116.00
IUUC-Mcc-054815	Macaca mulatta	74.74	0.00e+00	1136.00
IUUC-Meu-056436	Macropus eugenii	56.40	0.00e+00	777.00
IUUC-Mga-059723	Meleagris gallopavo	66.62	0.00e+00	992.00
IUUC-Mmr-060806	Microcebus murinus	74.50	0.00e+00	1115.00
IUUC-Mdo-062805	Monodelphis domestica	74.05	0.00e+00	1129.00
IUUC-Mmu-064034	Mus musculus	74.74	0.00e+00	1134.00
IUUC-Mpu-066762	Mustela putorius furo	74.43	0.00e+00	1118.00
IUUC-Mlu-066981	Myotis lucifugus	74.60	0.00e+00	1115.00
IUUC-Nle-069804	Nomascus leucogenys	74.67	0.00e+00	1129.00
IUUC-Opr-070591	Ochotona princeps	70.24	0.00e+00	1030.00
IUUC-Ont-072243	Oreochromis niloticus	71.66	0.00e+00	1129.00
IUUC-Oan-072699	Ornithorhynchus anatinus	72.80	0.00e+00	1135.00
IUUC-Ocu-074913	Oryctolagus cuniculus	74.61	0.00e+00	1134.00
IUUC-Ola-086597	Oryzias latipes	69.38	0.00e+00	1024.00
IUUC-Oga-089116	Otolemur garnettii	72.06	0.00e+00	1067.00
IUUC-Oar-089366	Ovis aries	74.50	0.00e+00	1116.00
IUUC-Ptr-091382	Pan troglodytes	74.48	0.00e+00	1133.00
IUUC-Pan-092479	Papio anubis	64.42	0.00e+00	971.00
IUUC-Psi-093298	Pelodiscus sinensis	74.13	0.00e+00	1118.00
IUUC-Pfo-096071	Poecilia formosa	73.43	0.00e+00	1142.00
IUUC-Pab-098682	Pongo abelii	74.48	0.00e+00	1134.00
IUUC-Pca-100516	Procavia capensis	67.92	5.00e-130	457.00
IUUC-Pva-102754	Pteropus vampyrus	73.46	0.00e+00	1078.00
IUUC-Rno-105600	Rattus norvegicus	73.01	0.00e+00	936.00
IUUC-Sha-107144	Sarcophilus harrisii	73.28	0.00e+00	1012.00
IUUC-Sar-113122	Sorex araneus	64.75	0.00e+00	912.00
IUUC-Ssc-116413	Sus scrofa	67.11	0.00e+00	959.00
IUUC-Tgu-117112	Taeniopygia guttata	73.76	0.00e+00	1137.00
IUUC-Tru-118497	Takifugu rubripes	72.37	0.00e+00	1104.00
IUUC-Tsy-118819	Tarsius syrichta	73.70	0.00e+00	761.00
IUUC-Tni-120829	Tetraodon nigroviridis	68.93	0.00e+00	719.00
IUUC-Tbe-127371	Tupaia belangeri	67.53	0.00e+00	909.00
IUUC-Ttr-129305	Tursiops truncatus	75.25	0.00e+00	1050.00
IUUC-Vpa-130591	Vicugna pacos	70.34	0.00e+00	1018.00
IUUC-Xtr-132979	Xenopus tropicalis	62.65	0.00e+00	884.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence