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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063571
UUCD1 version UUC-MuM-00412
Ensembl Protein ID ENSMUSP00000084400.4
UniProt Accession Q3UWA4; B2RVT3; TRI40_MOUSE
Genbank Protein ID BAE23012.1; AAI47337.1; AAI47338.1
Protein Name Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase
Genbank Nucleotide ID AK136498; BC147336; BC147337
Gene Name Trim40; Gm319
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000073399.9 ENSMUST00000087158.10 ENSMUSP00000084400.4
ENSMUSG00000073399.9 ENSMUST00000172711.1 ENSMUSP00000133581.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.80e-08 35.9 12 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+  ++++C H+f++ Cl q++   k s s+  +CP+Cr
   Q: 12   CPICLDPLKE-AVSTDCRHLFCRMCLtQHM--DKASVSGILSCPVCR 55
           ********99.999************8777..7778999999****8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity).
 May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity).
Protein Sequence
(Fasta)
MGSLDKDNQD ICPICLDPLK EAVSTDCRHL FCRMCLTQHM DKASVSGILS CPVCRKPCSE 60
GVLGDNYICH THQKRVRRFC EASGHLLCEE CLQSPEHQSH TELSIENAIS HYKERLNRRS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063571|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGGAGGAA TCTCTTCACC TTCTCCCTAG TTTCACAGGC ATGTGAGTGT ATATAATTGG 60
CATAATTCAA GAAGAACCGG CTCATCTGCT GGTCTTCTCC CTAGGTCTGG AGACCAAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063571|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0008270--F:zinc ion binding
GO:0030308--P:negative regulation of cell growth
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042177--P:negative regulation of protein catabolic process
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0045116--P:protein neddylation
KEGG mmu:195359
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001427 Ailuropoda melanoleuca 50.21 3.00e-44 171.00
IUUC-Afl-008526 Aspergillus flavus 41.38 1.00e-07 49.30
IUUC-Bta-012543 Bos taurus 52.63 6.00e-55 207.00
IUUC-Cja-018793 Callithrix jacchus 54.69 1.00e-55 209.00
IUUC-Csa-023101 Chlorocebus sabaeus 61.28 2.00e-72 265.00
IUUC-Cho-024926 Choloepus hoffmanni 56.34 2.00e-18 85.90
IUUC-Cme-027149 Cyanidioschyzon merolae 34.48 1.00e-06 48.90
IUUC-Dno-029338 Dasypus novemcinctus 46.88 6.00e-39 154.00
IUUC-Dor-030164 Dipodomys ordii 59.91 2.00e-62 232.00
IUUC-Dse-031337 Dothistroma septosporum 45.10 1.00e-07 50.80
IUUC-Ete-032446 Echinops telfairi 43.53 4.00e-44 171.00
IUUC-Eca-034042 Equus caballus 66.52 2.00e-78 285.00
IUUC-Eeu-034444 Erinaceus europaeus 53.85 5.00e-57 213.00
IUUC-Ggo-044410 Gorilla gorilla 62.87 2.00e-75 275.00
IUUC-Hsa-046211 Homo sapiens 62.45 9.00e-75 273.00
IUUC-Itr-048126 Ictidomys tridecemlineatus 60.57 2.00e-71 261.00
IUUC-Laf-054019 Loxodonta africana 51.30 8.00e-48 183.00
IUUC-Mcc-054616 Macaca mulatta 67.93 7.00e-84 303.00
IUUC-Meu-055981 Macropus eugenii 39.34 1.00e-30 125.00
IUUC-Mdo-062958 Monodelphis domestica 44.55 3.00e-33 135.00
IUUC-Nle-069843 Nomascus leucogenys 65.57 6.00e-28 116.00
IUUC-Opr-071083 Ochotona princeps 52.79 1.00e-62 233.00
IUUC-Ocu-073939 Oryctolagus cuniculus 59.13 3.00e-61 228.00
IUUC-Oga-088040 Otolemur garnettii 67.56 2.00e-73 268.00
IUUC-Oar-089914 Ovis aries 57.45 8.00e-67 246.00
IUUC-Ptr-091240 Pan troglodytes 61.28 4.00e-65 240.00
IUUC-Pan-092095 Papio anubis 66.37 2.00e-77 281.00
IUUC-Pab-098406 Pongo abelii 61.73 1.00e-75 275.00
IUUC-Pca-101043 Procavia capensis 52.97 3.00e-56 211.00
IUUC-Pva-102651 Pteropus vampyrus 61.73 2.00e-79 288.00
IUUC-Rno-106090 Rattus norvegicus 85.43 2.00e-112 398.00
IUUC-Ssc-115942 Sus scrofa 58.75 3.00e-71 261.00
IUUC-Tsy-119497 Tarsius syrichta 61.32 2.00e-76 278.00
IUUC-Tbe-127279 Tupaia belangeri 56.79 4.00e-53 201.00
Created Date 25-Jun-2017

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