iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074915

Ensembl Protein ID

ENSOCUP00000006372.3

UniProt Accession

G1SSX1; G1SSX1_RABIT

Protein Name

Uncharacterized protein

Gene Name

SLX4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000007367.3	ENSOCUT00000007369.3	ENSOCUP00000006372.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.50e-08	33.4	630	699
UBD/ZnF/UBZ	8.70e-09	35.5	234	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflme....leesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+++v+ ge+  ahk vL a+++ +    ++e     e+++ + +v ++dv+++++ra+l++lYt   
   Q: 630  SDVQFQVDsGEVLYAHKFVLYARCPLLIQHVNNEgfcaVEDGDRSQRVLLSDVSAKAVRAFLQYLYTADS 699
           69*************************9999655443356788899*********************865 PP

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++ ++e+H+++Cl
   Q: 234  FFCQICQKNlsmMSVARREQHVNRCL 259
           89****888888*************8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MDESDDDFQE LCASFLQRVK KNGTKQVSGE KKTQKASNGT QIRSKLKKSK QNATKAEPLP 60
GPAEKKPPPG SLSPRAKKTR KTKSQASDLA VTVNGEARAL APAAHQPGLG ERAQGTQTES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGAAGGT AAATGCACCA ACTGTGTTTT ATCACCGTGG GCCCCTTGAA GCGCGCTGTG 60
AGCCCCCCGT TCGTCTGTGT TCTACTTCAG AGGCATCTCT TGGACACCGC TCTCTGACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF09494--Slx4

SMART

SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001225	Ailuropoda melanoleuca	56.55	0.00e+00	1169.00
IUUC-Apl-003261	Anas platyrhynchos	40.76	8.00e-145	508.00
IUUC-Acl-008026	Aspergillus clavatus	25.00	8.30e-01	29.60
IUUC-Ame-010993	Astyanax mexicanus	28.79	2.00e-14	72.40
IUUC-Bta-013472	Bos taurus	54.58	0.00e+00	1233.00
IUUC-Cel-018663	Caenorhabditis elegans	29.03	8.00e-03	35.80
IUUC-Cja-019406	Callithrix jacchus	58.04	0.00e+00	1398.00
IUUC-Cfa-020129	Canis familiaris	56.81	0.00e+00	1301.00
IUUC-Cpo-021944	Cavia porcellus	51.95	0.00e+00	1170.00
IUUC-Csa-023941	Chlorocebus sabaeus	53.80	1.00e-161	563.00
IUUC-Cho-024847	Choloepus hoffmanni	65.47	2.00e-146	513.00
IUUC-Cin-025405	Ciona intestinalis	40.38	4.00e-05	42.00
IUUC-Dre-027764	Danio rerio	32.28	6.00e-79	290.00
IUUC-Dno-030083	Dasypus novemcinctus	55.69	0.00e+00	1256.00
IUUC-Dor-031129	Dipodomys ordii	56.08	0.00e+00	665.00
IUUC-Ete-032536	Echinops telfairi	44.50	3.00e-101	363.00
IUUC-Eca-033407	Equus caballus	58.28	0.00e+00	1164.00
IUUC-Eeu-034473	Erinaceus europaeus	50.00	4.00e-27	117.00
IUUC-Fca-035730	Felis catus	56.21	0.00e+00	1258.00
IUUC-Fal-036850	Ficedula albicollis	41.35	7.00e-131	462.00
IUUC-Gmo-038677	Gadus morhua	43.20	9.00e-33	135.00
IUUC-Gga-041088	Gallus gallus	40.78	1.00e-130	461.00
IUUC-Gac-041824	Gasterosteus aculeatus	73.68	2.00e-12	65.50
IUUC-Ggo-045642	Gorilla gorilla	57.67	0.00e+00	1339.00
IUUC-Hsa-047035	Homo sapiens	59.44	0.00e+00	1434.00
IUUC-Itr-049010	Ictidomys tridecemlineatus	60.69	0.00e+00	1474.00
IUUC-Lch-050364	Latimeria chalumnae	37.13	2.00e-69	257.00
IUUC-Loc-052423	Lepisosteus oculatus	41.64	1.00e-41	166.00
IUUC-Laf-053910	Loxodonta africana	54.72	0.00e+00	1250.00
IUUC-Mcc-055883	Macaca mulatta	59.73	0.00e+00	1447.00
IUUC-Meu-056224	Macropus eugenii	47.95	5.00e-46	180.00
IUUC-Mga-059880	Meleagris gallopavo	44.62	9.00e-137	481.00
IUUC-Mmr-061715	Microcebus murinus	62.49	0.00e+00	1613.00
IUUC-Mdo-062426	Monodelphis domestica	41.71	0.00e+00	929.00
IUUC-Mmu-063947	Mus musculus	53.13	0.00e+00	1265.00
IUUC-Mpu-066184	Mustela putorius furo	62.89	0.00e+00	887.00
IUUC-Mlu-067533	Myotis lucifugus	58.38	0.00e+00	1330.00
IUUC-Nle-069204	Nomascus leucogenys	58.28	0.00e+00	1443.00
IUUC-Opr-070377	Ochotona princeps	62.64	0.00e+00	932.00
IUUC-Ont-072551	Oreochromis niloticus	31.73	2.00e-71	265.00
IUUC-Oan-073350	Ornithorhynchus anatinus	45.99	1.00e-98	353.00
IUUC-Ola-087360	Oryzias latipes	41.31	6.00e-32	130.00
IUUC-Oga-089106	Otolemur garnettii	56.43	0.00e+00	1141.00
IUUC-Oar-089289	Ovis aries	57.27	0.00e+00	811.00
IUUC-Ptr-091469	Pan troglodytes	59.77	0.00e+00	1439.00
IUUC-Pan-091841	Papio anubis	58.09	0.00e+00	1077.00
IUUC-Psi-093842	Pelodiscus sinensis	44.67	4.00e-124	440.00
IUUC-Pma-094732	Petromyzon marinus	54.93	1.00e-08	52.80
IUUC-Pfo-097299	Poecilia formosa	38.33	2.00e-33	138.00
IUUC-Pab-098271	Pongo abelii	59.34	0.00e+00	1434.00
IUUC-Pca-100721	Procavia capensis	57.40	0.00e+00	773.00
IUUC-Pva-102276	Pteropus vampyrus	60.63	0.00e+00	1467.00
IUUC-Rno-105619	Rattus norvegicus	55.52	0.00e+00	1404.00
IUUC-Sha-106722	Sarcophilus harrisii	42.38	0.00e+00	674.00
IUUC-Sar-113673	Sorex araneus	55.47	6.00e-75	276.00
IUUC-Ssc-115383	Sus scrofa	58.31	0.00e+00	719.00
IUUC-Tgu-117243	Taeniopygia guttata	47.93	7.00e-91	327.00
IUUC-Tru-118092	Takifugu rubripes	40.47	2.00e-31	129.00
IUUC-Tsy-119362	Tarsius syrichta	65.13	1.00e-152	535.00
IUUC-Tni-120380	Tetraodon nigroviridis	70.31	1.00e-20	92.80
IUUC-Tbe-127404	Tupaia belangeri	47.99	4.00e-168	586.00
IUUC-Ttr-128317	Tursiops truncatus	58.55	0.00e+00	1290.00
IUUC-Xtr-132533	Xenopus tropicalis	37.81	1.00e-86	315.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence