iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088267

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03001550

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000013145.2	ENSOGAT00000013152.2	ENSOGAP00000011779.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.50e-10	39.4	15	60
E3 activity/RING/U-box	1.70e-06	28.0	9	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle + + pl+++CgH f++ C+ q+   + n + +e +CP+C+
   Q: 15   CPICLELLTE-PLSVDCGHSFCKACItQNSGESENGQEGESSCPVCQ 60
           ********99.***************88889***************7 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk........tcPvtrqplteedlvPnltlrrl 64
           + ee  CpI lel ++P  + +G+++ +++I +   sg++        +cPv++ + +  +l Pn  l ++
   Q: 9    IQEEVTCPICLELLTEPLSVDCGHSFCKACITQN--SGESengqegesSCPVCQVSYQLGSLRPNRHLANI 77
           67999**************************995..554455777888*****************998766 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

TMTSVLMDIQ EEVTCPICLE LLTEPLSVDC GHSFCKACIT QNSGESENGQ EGESSCPVCQ 60
VSYQLGSLRP NRHLANIAER LREVVLVPGK LPKAILCANH GEKLQLFCKE DGKVICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAATGACTT CTGTGCTGAT GGACATACAA GAGGAAGTGA CCTGCCCCAT CTGCCTGGAG 60
CTCCTGACAG AGCCTTTGAG TGTAGACTGT GGCCACAGCT TCTGTAAAGC CTGCATCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	82.30	0.00e+00	798.00
IUUC-Bta-013110	Bos taurus	55.24	3.00e-152	531.00
IUUC-Cja-019944	Callithrix jacchus	53.75	2.00e-135	475.00
IUUC-Cfa-021152	Canis familiaris	56.16	1.00e-147	516.00
IUUC-Cpo-021369	Cavia porcellus	55.89	6.00e-134	470.00
IUUC-Csa-023785	Chlorocebus sabaeus	57.26	6.00e-154	537.00
IUUC-Cho-024416	Choloepus hoffmanni	62.40	3.00e-86	312.00
IUUC-Dno-029492	Dasypus novemcinctus	55.06	1.00e-149	523.00
IUUC-Dor-030480	Dipodomys ordii	77.85	4.00e-129	455.00
IUUC-Ete-033021	Echinops telfairi	47.79	4.00e-107	381.00
IUUC-Eca-033207	Equus caballus	56.12	6.00e-148	517.00
IUUC-Eeu-034968	Erinaceus europaeus	48.74	1.00e-101	363.00
IUUC-Fca-035533	Felis catus	83.95	0.00e+00	812.00
IUUC-Ggo-044550	Gorilla gorilla	55.31	1.00e-136	479.00
IUUC-Hsa-046006	Homo sapiens	85.07	0.00e+00	847.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	79.96	0.00e+00	756.00
IUUC-Laf-053805	Loxodonta africana	77.16	0.00e+00	708.00
IUUC-Mcc-054743	Macaca mulatta	55.76	1.00e-149	523.00
IUUC-Mmr-061023	Microcebus murinus	87.27	0.00e+00	829.00
IUUC-Mmu-063682	Mus musculus	78.81	0.00e+00	780.00
IUUC-Mpu-065842	Mustela putorius furo	81.72	0.00e+00	789.00
IUUC-Mlu-067658	Myotis lucifugus	59.30	5.00e-146	511.00
IUUC-Nle-068980	Nomascus leucogenys	55.31	1.00e-147	516.00
IUUC-Opr-071057	Ochotona princeps	50.73	2.00e-121	428.00
IUUC-Ocu-073956	Oryctolagus cuniculus	53.22	2.00e-134	473.00
IUUC-Oar-089984	Ovis aries	57.55	2.00e-137	482.00
IUUC-Ptr-090573	Pan troglodytes	85.66	0.00e+00	850.00
IUUC-Pan-092745	Papio anubis	85.86	0.00e+00	832.00
IUUC-Pab-098535	Pongo abelii	55.51	7.00e-147	513.00
IUUC-Pca-100258	Procavia capensis	57.52	2.00e-143	503.00
IUUC-Pva-102482	Pteropus vampyrus	58.11	9.00e-140	491.00
IUUC-Rno-105401	Rattus norvegicus	79.63	0.00e+00	788.00
IUUC-Sar-113094	Sorex araneus	47.84	1.00e-103	370.00
IUUC-Ssc-115715	Sus scrofa	52.73	4.00e-134	471.00
IUUC-Tsy-119181	Tarsius syrichta	84.39	6.00e-123	434.00
IUUC-Tbe-127868	Tupaia belangeri	54.55	3.00e-127	448.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence