iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062661

Ensembl Protein ID

ENSMODP00000020873.2

UniProt Accession

F7CHI9; F7CHI9_MONDO

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000016719.3	ENSMODT00000021240.3	ENSMODP00000020873.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	86.55	0.00e+00	930.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKSS GVALLHQIQG NELEPLNRQQ LKIPLDRPLG EMYVDSNKTG VYNYPEGAAY 60
DFNTAAAPVY GSSNLTYNPS SETFSSNGLG GFHSLNNVSP SPLVLLHPPP QLSPFLHHHS 120

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Nucleotide Sequence
(Fasta)

TGCCACAGAG CAGATTTCAC CAAAACAGAG AATGCAAGGG CACATGCACA GAAGCTGTTT 60
AATGGGCTAG AAAGGTTAAT AGTCCTTCCT CCTGCATATT CTATAGTATA AGAAGACAGA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

KEGG

mdo:100027187

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	91.54	0.00e+00	783.00
IUUC-Apl-003688	Anas platyrhynchos	85.74	0.00e+00	874.00
IUUC-Aca-005222	Anolis carolinensis	82.68	0.00e+00	947.00
IUUC-Ame-010731	Astyanax mexicanus	52.99	2.00e-139	489.00
IUUC-Bta-013112	Bos taurus	82.21	0.00e+00	915.00
IUUC-Cja-019408	Callithrix jacchus	87.90	0.00e+00	947.00
IUUC-Cfa-020694	Canis familiaris	84.40	0.00e+00	914.00
IUUC-Cpo-021426	Cavia porcellus	80.54	0.00e+00	868.00
IUUC-Csa-023736	Chlorocebus sabaeus	90.35	0.00e+00	850.00
IUUC-Dre-027698	Danio rerio	53.26	4.00e-135	475.00
IUUC-Dno-029477	Dasypus novemcinctus	87.45	0.00e+00	747.00
IUUC-Dor-030572	Dipodomys ordii	88.96	0.00e+00	739.00
IUUC-Ete-032849	Echinops telfairi	70.04	0.00e+00	646.00
IUUC-Eca-033605	Equus caballus	83.03	0.00e+00	914.00
IUUC-Eeu-034683	Erinaceus europaeus	91.12	5.00e-109	387.00
IUUC-Fca-035928	Felis catus	91.50	0.00e+00	777.00
IUUC-Fal-036754	Ficedula albicollis	83.39	0.00e+00	969.00
IUUC-Gmo-038872	Gadus morhua	55.61	1.00e-114	406.00
IUUC-Gga-040988	Gallus gallus	84.41	0.00e+00	960.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.00	7.00e-130	457.00
IUUC-Ggo-044749	Gorilla gorilla	87.56	0.00e+00	942.00
IUUC-Hsa-046944	Homo sapiens	86.55	0.00e+00	930.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	85.38	0.00e+00	928.00
IUUC-Loc-052414	Lepisosteus oculatus	59.65	0.00e+00	670.00
IUUC-Mcc-054781	Macaca mulatta	87.56	0.00e+00	943.00
IUUC-Meu-056232	Macropus eugenii	95.93	0.00e+00	1057.00
IUUC-Mga-059319	Meleagris gallopavo	84.41	0.00e+00	960.00
IUUC-Mmr-061636	Microcebus murinus	85.33	9.00e-161	559.00
IUUC-Mmu-063330	Mus musculus	83.47	0.00e+00	880.00
IUUC-Mpu-065757	Mustela putorius furo	83.92	0.00e+00	938.00
IUUC-Mlu-067712	Myotis lucifugus	86.34	0.00e+00	823.00
IUUC-Nle-069283	Nomascus leucogenys	85.71	0.00e+00	909.00
IUUC-Opr-070391	Ochotona princeps	84.71	0.00e+00	947.00
IUUC-Ont-071369	Oreochromis niloticus	51.27	4.00e-123	435.00
IUUC-Oan-073734	Ornithorhynchus anatinus	78.95	1.00e-143	502.00
IUUC-Ocu-074292	Oryctolagus cuniculus	86.96	0.00e+00	940.00
IUUC-Oba-075103	Oryza barthii	28.21	1.00e-02	35.00
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.00
IUUC-Olo-080944	Oryza longistaminata	28.21	4.00e-03	34.70
IUUC-Oni-082560	Oryza nivara	28.21	8.00e-03	35.00
IUUC-Ola-087052	Oryzias latipes	53.54	9.00e-131	460.00
IUUC-Oga-088586	Otolemur garnettii	87.46	0.00e+00	931.00
IUUC-Oar-090156	Ovis aries	89.71	0.00e+00	805.00
IUUC-Ptr-091321	Pan troglodytes	87.39	0.00e+00	942.00
IUUC-Pan-092851	Papio anubis	87.39	0.00e+00	942.00
IUUC-Psi-093434	Pelodiscus sinensis	84.72	0.00e+00	995.00
IUUC-Pfo-097379	Poecilia formosa	58.21	1.00e-135	476.00
IUUC-Pab-097735	Pongo abelii	87.23	0.00e+00	939.00
IUUC-Pva-102125	Pteropus vampyrus	85.02	0.00e+00	925.00
IUUC-Rno-106121	Rattus norvegicus	83.17	0.00e+00	879.00
IUUC-Sha-107547	Sarcophilus harrisii	98.30	0.00e+00	1084.00
IUUC-Sar-113650	Sorex araneus	76.57	2.00e-176	611.00
IUUC-Tgu-117175	Taeniopygia guttata	83.88	0.00e+00	965.00
IUUC-Tru-117545	Takifugu rubripes	53.21	1.00e-139	490.00
IUUC-Tsy-119586	Tarsius syrichta	73.15	0.00e+00	791.00
IUUC-Tni-120121	Tetraodon nigroviridis	52.20	2.00e-141	496.00
IUUC-Tbe-127548	Tupaia belangeri	79.05	5.00e-178	617.00
IUUC-Ttr-128374	Tursiops truncatus	79.50	0.00e+00	832.00
IUUC-Vpa-130464	Vicugna pacos	80.87	1.00e-151	529.00
IUUC-Xtr-132171	Xenopus tropicalis	74.41	0.00e+00	790.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence