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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106454
UUCD1 version UUC-SaC-00004
Ensembl Protein ID YCR066W
UniProt Accession P10862; D6VR69; Q58AT6; RAD18_YEAST
Genbank Protein ID CAA31059.1; AAA34932.1; CAA31101.1; CAA42281.1; DAA07538.1
Protein Name Postreplication repair E3 ubiquitin-protein ligase RAD18; RING-type E3 ubiquitin transferase RAD18; Radiation sensitivity protein 18
Genbank Nucleotide ID X12542; M36405; X12588; X59720; BK006937
Gene Name RAD18; YCR066W; YCR66W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YCR066W YCR066W YCR066W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17130289
UBD/ZnF/UBZ UBZ 17550899
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.90e-06 24.8 28 65
UBD/ZnF/UBZ 4.70e-09 34.8 189 211
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC++ +k  p+++pCgH+f+  C+          +++ +CPlC
   Q: 28   CHICKDFLKV-PVLTPCGHTFCSLCIRTH------LNNQPNCPLC 65
           99**999988.999************777......8********* PP
   

   UBD/ZnF/UBZ
   S: 3    vCPvCqkmvdqtdfee.HlDeCl 24
           +CP+Cq++++++++e+ HlDeCl
   Q: 189  QCPICQQFYPLKALEKtHLDECL 211
           6*********************8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
 E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.
Protein Sequence
(Fasta)
MDHQITTASD FTTTSIPSLY QLDTLLRCHI CKDFLKVPVL TPCGHTFCSL CIRTHLNNQP 60
NCPLCLFEFR ESLLRSEFLV SEIIQSYTSL RSSLLDALRI PKPTPVPENE EVPGPENSSW 120
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Protein Fasta Sequence


>IUUC-Sce-106454|E3,RING;UBD,UBZ|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGACCACC AAATAACCAC TGCAAGCGAC TTCACGACTA CTTCAATACC GAGCCTGTAC 60
CAATTGGATA CACTTTTGAG ATGTCACATT TGTAAAGATT TTCTAAAAGT CCCCGTCTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106454|E3,RING;UBD,UBZ|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02037--SAP
SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18
Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV
KEGG sce:YCR066W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002086 Ailuropoda melanoleuca 24.85 7.00e-15 73.20
IUUC-Apl-003657 Anas platyrhynchos 25.49 4.00e-20 90.50
IUUC-Aca-005369 Anolis carolinensis 33.33 5.00e-11 58.20
IUUC-Ago-007876 Ashbya gossypii 41.77 2.00e-76 277.00
IUUC-Acl-008246 Aspergillus clavatus 25.39 2.00e-26 111.00
IUUC-Afl-008666 Aspergillus flavus 26.73 6.00e-27 113.00
IUUC-Afu-009052 Aspergillus fumigatus 24.19 4.00e-24 103.00
IUUC-Ani-009488 Aspergillus nidulans 25.18 5.00e-28 116.00
IUUC-Ang-009681 Aspergillus niger 25.19 8.00e-30 122.00
IUUC-Aor-010037 Aspergillus oryzae 24.87 5.00e-28 116.00
IUUC-Ate-010516 Aspergillus terreus 40.91 4.00e-17 79.30
IUUC-Ame-010630 Astyanax mexicanus 22.52 2.00e-18 84.30
IUUC-Bgr-012178 Blumeria graminis 29.52 1.00e-34 138.00
IUUC-Bta-012976 Bos taurus 31.71 2.00e-11 61.60
IUUC-Bci-013680 Botrytis cinerea 26.05 3.00e-35 140.00
IUUC-Cel-018356 Caenorhabditis elegans 47.37 3.00e-09 52.40
IUUC-Cja-019453 Callithrix jacchus 36.11 2.00e-11 62.00
IUUC-Cfa-020856 Canis familiaris 23.88 4.00e-16 77.40
IUUC-Cpo-021950 Cavia porcellus 37.33 1.00e-11 62.40
IUUC-Csa-023997 Chlorocebus sabaeus 36.00 1.00e-11 62.40
IUUC-Cho-024771 Choloepus hoffmanni 34.67 5.00e-11 60.50
IUUC-Cin-025364 Ciona intestinalis 32.14 8.00e-11 58.90
IUUC-Csv-026364 Ciona savignyi 48.84 9.00e-09 52.40
IUUC-Cgl-026668 Colletotrichum gloeosporioides 44.21 8.00e-22 95.90
IUUC-Cme-027202 Cyanidioschyzon merolae 37.18 2.00e-12 64.70
IUUC-Dre-028479 Danio rerio 23.81 1.00e-15 75.50
IUUC-Dno-028943 Dasypus novemcinctus 34.67 3.00e-11 60.80
IUUC-Dor-031046 Dipodomys ordii 29.75 4.00e-05 40.80
IUUC-Dme-031919 Drosophila melanogaster 43.59 2.00e-06 46.60
IUUC-Ete-032455 Echinops telfairi 37.93 3.00e-09 54.30
IUUC-Eca-033725 Equus caballus 36.00 1.00e-11 62.80
IUUC-Eeu-034573 Erinaceus europaeus 36.62 3.00e-11 60.80
IUUC-Fca-036495 Felis catus 24.41 2.00e-15 75.10
IUUC-Fal-036791 Ficedula albicollis 25.83 9.00e-19 86.30
IUUC-Fox-037868 Fusarium oxysporum 42.86 9.00e-23 99.00
IUUC-Fso-038144 Fusarium solani 38.78 7.00e-21 92.40
IUUC-Gmo-039315 Gadus morhua 38.98 7.00e-10 57.00
IUUC-Ggr-039737 Gaeumannomyces graminis 38.95 7.00e-20 89.70
IUUC-Gga-040788 Gallus gallus 26.12 2.00e-20 91.70
IUUC-Gac-041993 Gasterosteus aculeatus 21.34 1.00e-18 85.50
IUUC-Ggo-044889 Gorilla gorilla 36.00 9.00e-12 62.80
IUUC-Hsa-045957 Homo sapiens 36.00 1.00e-11 62.80
IUUC-Itr-048998 Ictidomys tridecemlineatus 32.93 8.00e-12 63.20
IUUC-Kpa-049300 Komagataella pastoris 29.50 5.00e-37 146.00
IUUC-Lch-050172 Latimeria chalumnae 36.00 2.00e-10 57.80
IUUC-Loc-052609 Lepisosteus oculatus 37.78 1.00e-12 65.90
IUUC-Lma-053037 Leptosphaeria maculans 23.55 2.00e-18 85.50
IUUC-Laf-054421 Loxodonta africana 43.94 3.00e-12 65.10
IUUC-Mcc-055853 Macaca mulatta 36.00 1.00e-11 62.40
IUUC-Meu-056070 Macropus eugenii 35.80 2.00e-09 55.50
IUUC-Mor-057071 Magnaporthe oryzae 25.91 2.00e-34 137.00
IUUC-Mpo-057628 Magnaporthe poae 38.46 1.00e-18 85.90
IUUC-Mla-058953 Melampsora laricipopulina 34.34 1.00e-11 62.80
IUUC-Mga-059687 Meleagris gallopavo 25.88 1.00e-16 79.30
IUUC-Mvi-060412 Microbotryum violaceum 39.18 2.00e-15 75.50
IUUC-Mmr-061563 Microcebus murinus 35.14 3.00e-11 60.80
IUUC-Mdo-062655 Monodelphis domestica 37.33 4.00e-13 67.40
IUUC-Mmu-063647 Mus musculus 40.00 1.00e-12 66.20
IUUC-Mac-065027 Musa acuminata 38.89 1.00e-11 62.80
IUUC-Mpu-065778 Mustela putorius furo 23.88 1.00e-15 75.90
IUUC-Mlu-068205 Myotis lucifugus 36.00 7.00e-11 60.10
IUUC-Nfi-068501 Neosartorya fischeri 24.27 2.00e-20 91.30
IUUC-Ncr-068917 Neurospora crassa 26.28 5.00e-32 130.00
IUUC-Nle-068990 Nomascus leucogenys 36.00 1.00e-11 62.40
IUUC-Opr-071146 Ochotona princeps 35.90 2.00e-11 61.60
IUUC-Ont-071835 Oreochromis niloticus 42.17 2.00e-13 68.60
IUUC-Oan-072827 Ornithorhynchus anatinus 33.33 5.00e-14 68.90
IUUC-Ocu-073986 Oryctolagus cuniculus 27.38 8.00e-19 86.30
IUUC-Ola-086997 Oryzias latipes 37.84 6.00e-12 62.80
IUUC-Olu-087771 Ostreococcus lucimarinus 36.84 3.00e-10 57.40
IUUC-Oga-088092 Otolemur garnettii 27.84 9.00e-18 82.80
IUUC-Oar-089651 Ovis aries 32.93 1.00e-11 62.80
IUUC-Ptr-091103 Pan troglodytes 36.00 1.00e-11 62.80
IUUC-Pan-092478 Papio anubis 36.00 1.00e-11 62.40
IUUC-Psi-093356 Pelodiscus sinensis 35.80 2.00e-13 68.20
IUUC-Pma-094517 Petromyzon marinus 36.36 3.00e-06 44.70
IUUC-Pfo-096663 Poecilia formosa 42.17 1.00e-12 65.90
IUUC-Pab-098515 Pongo abelii 36.00 1.00e-11 62.80
IUUC-Pop-098788 Populus trichocarpa 39.47 7.00e-11 59.70
IUUC-Pca-100588 Procavia capensis 30.23 8.00e-09 52.80
IUUC-Ppe-101428 Prunus persica 36.11 5.00e-11 60.10
IUUC-Pva-102377 Pteropus vampyrus 31.76 5.00e-11 60.50
IUUC-Pgr-103556 Puccinia graminis 31.46 3.00e-09 54.70
IUUC-Pte-104362 Pyrenophora teres 33.68 2.00e-15 75.10
IUUC-Pyt-104823 Pyrenophora triticirepentis 35.71 4.00e-14 70.50
IUUC-Rno-105866 Rattus norvegicus 40.00 5.00e-13 67.00
IUUC-Sha-107515 Sarcophilus harrisii 33.65 2.00e-13 67.80
IUUC-Sja-107689 Schizosaccharomyces japonicus 45.45 2.00e-25 108.00
IUUC-Spo-108248 Schizosaccharomyces pombe 27.89 1.00e-32 132.00
IUUC-Ssl-108430 Sclerotinia sclerotiorum 26.54 7.00e-32 129.00
IUUC-Sar-113220 Sorex araneus 37.88 2.00e-08 51.20
IUUC-Sre-115123 Sporisorium reilianum 50.00 2.00e-09 55.10
IUUC-Ssc-115992 Sus scrofa 27.67 1.00e-06 45.40
IUUC-Tgu-117286 Taeniopygia guttata 25.66 5.00e-24 103.00
IUUC-Tru-117959 Takifugu rubripes 48.00 7.00e-11 59.30
IUUC-Tsy-119286 Tarsius syrichta 37.74 5.00e-09 53.50
IUUC-Tni-120570 Tetraodon nigroviridis 38.55 3.00e-11 60.80
IUUC-Tre-121893 Trichoderma reesei 35.71 6.00e-17 79.70
IUUC-Tvi-122405 Trichoderma virens 35.79 3.00e-19 87.40
IUUC-Tbe-127758 Tupaia belangeri 34.67 7.00e-11 60.10
IUUC-Ttr-128841 Tursiops truncatus 36.14 1.00e-11 62.80
IUUC-Uma-129563 Ustilago maydis 51.92 3.00e-09 54.70
IUUC-Vda-130021 Verticillium dahliae 25.00 8.00e-13 65.50
IUUC-Vpa-130169 Vicugna pacos 34.18 3.00e-11 60.80
IUUC-Xtr-132308 Xenopus tropicalis 39.19 7.00e-13 66.20
IUUC-Xma-133868 Xiphophorus maculatus 52.94 4.00e-12 63.90
IUUC-Yli-134474 Yarrowia lipolytica 38.04 2.00e-18 84.30
Created Date 25-Jun-2017

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