iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074053

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAGW02058868

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006202.2	ENSOCUT00000006217.2	ENSOCUP00000005384.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.00e-30	103.2	272	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           kvC  C+++g+d+ ++++Ce C++ +H  Clk++  eelp ++ w C+ Cr
   Q: 272  KVCQACRKPGNDS-KMLVCETCDKGYHTFCLKPP-MEELPAHS-WKCKACR 319
           58*********87.6*******************.*******8.******8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MASQKPPGED KDSEPAADGA AASEEPGAPE PELPSPHVGE ASVPSPGSPR LQGPRGDCSE 60
GPARRCALCN CGEPSLHGQR ELRRVELPCD WPRCPVVSPG GNPGPSEDLS QIGFPEGLTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGCC AGAAACCGCC TGGCGAGGAT AAAGACTCAG AACCGGCAGG TGAGTAGGGT 60
GCGTCCTGGG TGTGCTGTCA GCTTTCTGTC TTCGTGGGCA ACCTTAGACT CCTGGTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	28.03	8.00e-14	72.40
IUUC-Aml-001806	Ailuropoda melanoleuca	85.95	0.00e+00	3821.00
IUUC-Aca-005364	Anolis carolinensis	51.86	0.00e+00	1272.00
IUUC-Ame-010612	Astyanax mexicanus	81.17	0.00e+00	1010.00
IUUC-Bta-013011	Bos taurus	84.70	0.00e+00	3879.00
IUUC-Cja-019841	Callithrix jacchus	87.50	0.00e+00	3766.00
IUUC-Cfa-021131	Canis familiaris	86.99	0.00e+00	3717.00
IUUC-Cpo-021957	Cavia porcellus	85.76	0.00e+00	3766.00
IUUC-Csa-023722	Chlorocebus sabaeus	88.68	0.00e+00	3701.00
IUUC-Dno-029932	Dasypus novemcinctus	83.17	0.00e+00	2189.00
IUUC-Dor-030192	Dipodomys ordii	83.43	0.00e+00	1702.00
IUUC-Ete-032572	Echinops telfairi	85.08	0.00e+00	1965.00
IUUC-Eca-034166	Equus caballus	87.85	0.00e+00	686.00
IUUC-Eeu-034848	Erinaceus europaeus	91.64	0.00e+00	1316.00
IUUC-Fca-035424	Felis catus	90.33	0.00e+00	3641.00
IUUC-Fal-037179	Ficedula albicollis	66.59	0.00e+00	1168.00
IUUC-Gmo-038719	Gadus morhua	82.21	0.00e+00	909.00
IUUC-Gga-040815	Gallus gallus	58.78	0.00e+00	1915.00
IUUC-Gac-042436	Gasterosteus aculeatus	79.86	0.00e+00	994.00
IUUC-Ggo-044711	Gorilla gorilla	90.42	0.00e+00	3563.00
IUUC-Hsa-046567	Homo sapiens	88.84	0.00e+00	3634.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	89.54	0.00e+00	3617.00
IUUC-Loc-051979	Lepisosteus oculatus	82.81	0.00e+00	1058.00
IUUC-Laf-054377	Loxodonta africana	89.06	0.00e+00	3567.00
IUUC-Mcc-055577	Macaca mulatta	87.92	0.00e+00	3635.00
IUUC-Meu-055992	Macropus eugenii	82.71	0.00e+00	1296.00
IUUC-Mmr-061772	Microcebus murinus	87.30	0.00e+00	3585.00
IUUC-Mdo-062876	Monodelphis domestica	80.73	0.00e+00	1120.00
IUUC-Mmu-063903	Mus musculus	85.53	0.00e+00	3472.00
IUUC-Mpu-066700	Mustela putorius furo	89.95	0.00e+00	3585.00
IUUC-Mlu-068180	Myotis lucifugus	87.03	0.00e+00	3788.00
IUUC-Nle-069362	Nomascus leucogenys	88.79	0.00e+00	3669.00
IUUC-Opr-070304	Ochotona princeps	86.35	0.00e+00	4618.00
IUUC-Ont-071881	Oreochromis niloticus	65.24	0.00e+00	1402.00
IUUC-Ola-086384	Oryzias latipes	60.93	0.00e+00	1313.00
IUUC-Oga-088450	Otolemur garnettii	86.96	0.00e+00	3871.00
IUUC-Oar-089975	Ovis aries	93.75	0.00e+00	2019.00
IUUC-Ptr-091073	Pan troglodytes	88.78	0.00e+00	3662.00
IUUC-Pan-092871	Papio anubis	89.12	0.00e+00	4801.00
IUUC-Pfo-097525	Poecilia formosa	63.59	0.00e+00	1320.00
IUUC-Pab-097679	Pongo abelii	90.43	0.00e+00	3621.00
IUUC-Pca-100499	Procavia capensis	74.30	0.00e+00	2247.00
IUUC-Pva-102898	Pteropus vampyrus	90.54	0.00e+00	3528.00
IUUC-Rno-105660	Rattus norvegicus	85.96	0.00e+00	3540.00
IUUC-Sha-107431	Sarcophilus harrisii	75.38	0.00e+00	3982.00
IUUC-Sbi-113816	Sorghum bicolor	31.78	6.00e-14	73.60
IUUC-Ssc-115678	Sus scrofa	89.97	0.00e+00	3488.00
IUUC-Tru-117922	Takifugu rubripes	80.39	0.00e+00	1009.00
IUUC-Tsy-118905	Tarsius syrichta	84.01	0.00e+00	1633.00
IUUC-Tbe-127625	Tupaia belangeri	75.00	0.00e+00	669.00
IUUC-Ttr-129162	Tursiops truncatus	80.41	0.00e+00	2254.00
IUUC-Xtr-132455	Xenopus tropicalis	64.27	0.00e+00	1301.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence