iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040771

Ensembl Protein ID

ENSGALP00000023298.1

UniProt Accession

Q5ZKY4; ING4_CHICK

Genbank Protein ID

CAG31609.1

Protein Name

Inhibitor of growth protein 4; p29ING4

Genbank Nucleotide ID

AJ719950

Gene Name

ING4; RCJMB04_8l5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000014457.4	ENSGALT00000023343.2	ENSGALP00000023298.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.10e-10	38.9	197	244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 197  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 244
           69*.*******99..********999***********...899996.******97 PP

Organism

Gallus gallus

Functional Description
(View)

Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (By similarity).

Protein Sequence
(Fasta)

MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKS EIDKLATEYI SNARTLSSEE 60
KLGLLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACGCCAGT GTGTCGGGGC CCAAGATGGC GGCGGGGATG TACCTGGAGC ACTACCTGGA 60
CAGTAAGAGC TGCCGGGGCG GGGCCGAGGG CCGCGGCTGA GGATGGACAG GCAGACCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

KEGG

gga:418281

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	95.58	1.00e-123	435.00
IUUC-Atr-002906	Amborella trichopoda	33.73	3.00e-34	137.00
IUUC-Apl-004097	Anas platyrhynchos	96.77	7.00e-123	432.00
IUUC-Aca-004593	Anolis carolinensis	100.00	2.00e-128	451.00
IUUC-Ame-011133	Astyanax mexicanus	81.67	2.00e-118	417.00
IUUC-Bta-012699	Bos taurus	94.38	1.00e-123	434.00
IUUC-Bdi-014504	Brachypodium distachyon	35.86	1.00e-39	155.00
IUUC-Bol-015245	Brassica oleracea	31.33	2.00e-30	125.00
IUUC-Bra-017027	Brassica rapa	31.73	3.00e-31	128.00
IUUC-Cja-019988	Callithrix jacchus	96.79	8.00e-119	419.00
IUUC-Cfa-021282	Canis familiaris	95.98	9.00e-118	415.00
IUUC-Cpo-022011	Cavia porcellus	95.98	2.00e-127	447.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	30.52	5.00e-29	120.00
IUUC-Csa-023203	Chlorocebus sabaeus	96.79	8.00e-119	419.00
IUUC-Dre-028264	Danio rerio	81.27	5.00e-117	412.00
IUUC-Dno-029766	Dasypus novemcinctus	93.15	3.00e-111	394.00
IUUC-Dor-031136	Dipodomys ordii	82.20	2.00e-96	344.00
IUUC-Dme-032200	Drosophila melanogaster	89.86	3.00e-40	158.00
IUUC-Eca-033565	Equus caballus	96.39	2.00e-127	447.00
IUUC-Eeu-034948	Erinaceus europaeus	77.73	5.00e-97	346.00
IUUC-Fca-036368	Felis catus	96.39	2.00e-118	417.00
IUUC-Fal-037120	Ficedula albicollis	96.37	2.00e-121	427.00
IUUC-Gmo-038982	Gadus morhua	82.40	3.00e-117	414.00
IUUC-Gac-042184	Gasterosteus aculeatus	81.71	3.00e-113	400.00
IUUC-Ggo-045559	Gorilla gorilla	96.79	8.00e-119	419.00
IUUC-Hsa-046852	Homo sapiens	96.79	8.00e-119	419.00
IUUC-Hvu-047046	Hordeum vulgare	36.51	1.00e-38	152.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	95.98	5.00e-127	446.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	1.00e-16	79.70
IUUC-Lpe-050822	Leersia perrieri	34.66	3.00e-39	154.00
IUUC-Laf-054057	Loxodonta africana	96.39	2.00e-118	417.00
IUUC-Mcc-055212	Macaca mulatta	90.84	6.00e-113	399.00
IUUC-Meu-056511	Macropus eugenii	95.34	7.00e-118	416.00
IUUC-Mga-059967	Meleagris gallopavo	97.57	3.00e-122	430.00
IUUC-Mmr-060843	Microcebus murinus	94.38	1.00e-123	435.00
IUUC-Mdo-062357	Monodelphis domestica	95.58	1.00e-126	444.00
IUUC-Mmu-064093	Mus musculus	95.98	2.00e-127	447.00
IUUC-Mpu-066923	Mustela putorius furo	84.74	1.00e-95	342.00
IUUC-Mlu-067754	Myotis lucifugus	89.29	2.00e-115	407.00
IUUC-Nle-069062	Nomascus leucogenys	96.79	8.00e-119	419.00
IUUC-Opr-070207	Ochotona princeps	89.83	5.00e-109	386.00
IUUC-Ont-072446	Oreochromis niloticus	82.80	6.00e-116	409.00
IUUC-Ocu-074235	Oryctolagus cuniculus	95.98	9.00e-118	415.00
IUUC-Ogl-077118	Oryza glaberrima	33.73	7.00e-37	146.00
IUUC-Ome-081291	Oryza meridionalis	34.13	2.00e-37	148.00
IUUC-Opu-084171	Oryza punctata	34.68	2.00e-36	145.00
IUUC-Osa-085563	Oryza sativa	34.13	2.00e-37	148.00
IUUC-Ola-086429	Oryzias latipes	78.00	6.00e-107	379.00
IUUC-Oga-089123	Otolemur garnettii	96.39	2.00e-118	417.00
IUUC-Oar-089524	Ovis aries	94.38	1.00e-123	434.00
IUUC-Ptr-090908	Pan troglodytes	96.39	2.00e-118	417.00
IUUC-Pan-092837	Papio anubis	95.98	3.00e-124	436.00
IUUC-Psi-093828	Pelodiscus sinensis	99.57	2.00e-117	414.00
IUUC-Ppa-096009	Physcomitrella patens	32.81	1.00e-32	133.00
IUUC-Pfo-096617	Poecilia formosa	82.40	6.00e-116	409.00
IUUC-Pab-097978	Pongo abelii	96.19	3.00e-108	384.00
IUUC-Pop-099415	Populus trichocarpa	73.68	2.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	64.26	2.00e-82	298.00
IUUC-Pva-102325	Pteropus vampyrus	96.39	2.00e-127	447.00
IUUC-Rno-105178	Rattus norvegicus	94.38	2.00e-132	464.00
IUUC-Sha-106773	Sarcophilus harrisii	95.58	1.00e-126	445.00
IUUC-Sly-111750	Solanum lycopersicum	34.26	2.00e-36	145.00
IUUC-Stu-112250	Solanum tuberosum	34.26	2.00e-36	145.00
IUUC-Sre-115124	Sporisorium reilianum	51.85	9.00e-23	102.00
IUUC-Ssc-115797	Sus scrofa	89.84	2.00e-103	367.00
IUUC-Tgu-117270	Taeniopygia guttata	100.00	2.00e-128	451.00
IUUC-Tru-118253	Takifugu rubripes	81.67	5.00e-116	409.00
IUUC-Tca-121597	Theobroma cacao	69.84	3.00e-28	118.00
IUUC-Tbe-127558	Tupaia belangeri	95.58	1.00e-123	435.00
IUUC-Ttr-128300	Tursiops truncatus	97.27	5.00e-64	236.00
IUUC-Uma-129581	Ustilago maydis	57.63	3.00e-21	96.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence