iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRNAMap	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.00e-10	39.0	193	240

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 193  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 240
           69*.*******99..********999***********...899996.******97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 60
KLALLRQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGATGGCT GCTGGGATGT ATTTGGAACA TTATCTGGAC AGTAAGAGCC GACTGGAGAA 60
GGGGACATGG GTCATAGAGT GGTGTAGAGG GTCCGGGTTG ACAGACTATA TGGCCCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

KEGG

rno:297597

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	98.39	6.00e-127	446.00
IUUC-Atr-002906	Amborella trichopoda	33.20	2.00e-35	142.00
IUUC-Apl-004097	Anas platyrhynchos	88.31	4.00e-117	413.00
IUUC-Aca-004593	Anolis carolinensis	91.57	9.00e-123	432.00
IUUC-Ame-011133	Astyanax mexicanus	82.07	3.00e-118	417.00
IUUC-Bta-012699	Bos taurus	97.98	3.00e-127	447.00
IUUC-Bdi-014504	Brachypodium distachyon	36.44	1.00e-39	156.00
IUUC-Bol-015245	Brassica oleracea	31.84	1.00e-30	125.00
IUUC-Bra-017027	Brassica rapa	32.24	5.00e-31	127.00
IUUC-Cja-019988	Callithrix jacchus	94.78	2.00e-119	421.00
IUUC-Cfa-021282	Canis familiaris	94.78	2.00e-119	421.00
IUUC-Cpo-022011	Cavia porcellus	95.58	7.00e-130	456.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	31.73	4.00e-29	121.00
IUUC-Csa-023203	Chlorocebus sabaeus	94.78	2.00e-119	421.00
IUUC-Cin-025479	Ciona intestinalis	62.82	3.00e-80	291.00
IUUC-Csv-026288	Ciona savignyi	54.31	3.00e-75	275.00
IUUC-Dre-028264	Danio rerio	81.67	1.00e-116	412.00
IUUC-Dno-029766	Dasypus novemcinctus	91.94	9.00e-113	399.00
IUUC-Dor-031136	Dipodomys ordii	80.93	3.00e-98	350.00
IUUC-Dme-032200	Drosophila melanogaster	74.19	2.00e-40	159.00
IUUC-Eca-033565	Equus caballus	94.78	4.00e-129	453.00
IUUC-Eeu-034948	Erinaceus europaeus	79.27	2.00e-100	357.00
IUUC-Fca-036368	Felis catus	95.18	8.00e-120	422.00
IUUC-Fal-037120	Ficedula albicollis	87.90	1.00e-115	409.00
IUUC-Gmo-038982	Gadus morhua	80.80	1.00e-116	412.00
IUUC-Gga-040771	Gallus gallus	91.57	9.00e-123	432.00
IUUC-Gac-042184	Gasterosteus aculeatus	80.08	6.00e-113	399.00
IUUC-Gma-044339	Glycine max	30.24	1.00e-34	139.00
IUUC-Ggo-045559	Gorilla gorilla	94.78	2.00e-119	421.00
IUUC-Hsa-046852	Homo sapiens	94.78	2.00e-119	421.00
IUUC-Hvu-047046	Hordeum vulgare	35.34	2.00e-37	149.00
IUUC-Itr-047978	Ictidomys tridecemlineatus	95.18	2.00e-129	454.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	1.00e-16	79.30
IUUC-Lpe-050822	Leersia perrieri	34.82	4.00e-38	151.00
IUUC-Laf-054057	Loxodonta africana	95.18	8.00e-120	422.00
IUUC-Mcc-055212	Macaca mulatta	92.03	9.00e-115	405.00
IUUC-Meu-056511	Macropus eugenii	91.53	5.00e-120	423.00
IUUC-Mtr-058089	Medicago truncatula	32.26	2.00e-35	142.00
IUUC-Mga-059967	Meleagris gallopavo	89.07	1.00e-116	411.00
IUUC-Mmr-060843	Microcebus murinus	99.19	1.00e-128	451.00
IUUC-Mdo-062357	Monodelphis domestica	94.38	1.00e-128	452.00
IUUC-Mmu-064093	Mus musculus	95.58	7.00e-130	456.00
IUUC-Mac-064625	Musa acuminata	34.01	2.00e-37	148.00
IUUC-Mpu-066923	Mustela putorius furo	81.53	1.00e-96	345.00
IUUC-Mlu-067754	Myotis lucifugus	86.90	4.00e-117	414.00
IUUC-Nle-069062	Nomascus leucogenys	94.78	2.00e-119	421.00
IUUC-Opr-070207	Ochotona princeps	87.71	3.00e-110	390.00
IUUC-Ont-072446	Oreochromis niloticus	81.20	9.00e-114	402.00
IUUC-Ocu-074235	Oryctolagus cuniculus	94.78	2.00e-119	421.00
IUUC-Obr-076266	Oryza brachyantha	35.22	3.00e-38	151.00
IUUC-Ogl-077118	Oryza glaberrima	33.73	3.00e-35	142.00
IUUC-Ome-081291	Oryza meridionalis	34.54	6.00e-36	144.00
IUUC-Opu-084171	Oryza punctata	34.68	7.00e-37	147.00
IUUC-Osa-085563	Oryza sativa	34.54	6.00e-36	144.00
IUUC-Ola-086429	Oryzias latipes	76.40	1.00e-106	378.00
IUUC-Olu-087851	Ostreococcus lucimarinus	34.81	2.00e-20	92.40
IUUC-Oga-089123	Otolemur garnettii	95.18	8.00e-120	422.00
IUUC-Oar-089524	Ovis aries	97.98	3.00e-127	447.00
IUUC-Ptr-090908	Pan troglodytes	94.38	8.00e-119	419.00
IUUC-Pan-092837	Papio anubis	97.98	2.00e-126	444.00
IUUC-Psi-093828	Pelodiscus sinensis	90.99	3.00e-112	397.00
IUUC-Ppa-096009	Physcomitrella patens	34.38	7.00e-35	140.00
IUUC-Pfo-096617	Poecilia formosa	80.80	2.00e-115	407.00
IUUC-Pab-097978	Pongo abelii	94.07	1.00e-108	385.00
IUUC-Pop-099415	Populus trichocarpa	73.68	2.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	64.26	3.00e-84	304.00
IUUC-Ppe-101441	Prunus persica	33.73	3.00e-37	147.00
IUUC-Pva-102325	Pteropus vampyrus	94.78	4.00e-129	453.00
IUUC-Sha-106773	Sarcophilus harrisii	94.38	2.00e-128	451.00
IUUC-Sit-109827	Setaria italica	33.20	6.00e-37	147.00
IUUC-Sly-111750	Solanum lycopersicum	34.68	3.00e-36	144.00
IUUC-Stu-112250	Solanum tuberosum	34.68	3.00e-36	144.00
IUUC-Sbi-114826	Sorghum bicolor	33.20	3.00e-38	151.00
IUUC-Sre-115124	Sporisorium reilianum	58.21	2.00e-22	100.00
IUUC-Ssc-115797	Sus scrofa	88.21	7.00e-104	369.00
IUUC-Tgu-117270	Taeniopygia guttata	91.57	9.00e-123	432.00
IUUC-Tru-118253	Takifugu rubripes	80.08	1.00e-115	409.00
IUUC-Tca-121597	Theobroma cacao	31.05	4.00e-31	127.00
IUUC-Tae-123043	Triticum aestivum	34.75	2.00e-37	149.00
IUUC-Tbe-127558	Tupaia belangeri	98.39	6.00e-127	446.00
IUUC-Ttr-128300	Tursiops truncatus	100.00	1.00e-65	242.00
IUUC-Uma-129581	Ustilago maydis	57.63	3.00e-21	97.10
IUUC-Yli-134326	Yarrowia lipolytica	28.42	5.00e-25	107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence