iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.20e-17	65.1	34	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+lvv+++e+++h++vLaa+S++F++lf+ +   s+    +ei+ vqpe++ a+l+F Yt++l++
   Q: 34   CDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGSLASQ-PYVYEIDFVQPEALAAILEFAYTSTLTI 99
           9************************************9.************************9976 PP

Organism

Mus musculus

Functional Description
(View)

May be a tumor suppressor gene.

Protein Sequence
(Fasta)

MANDIDELIG IPFPNHSSEV LCSLNEQRHA GLLCDVLLVV QEQEYRTHRS VLAACSKYFK 60
KLFTAGSLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT ASNVKHILNA ARMLEIQCIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCCCGCT CGACTGATGC TCGGCTGCAC AGCCGCTGGA GCAACCCGGG CCACGAGACT 60
CTTGACAGCG GCGCGGCCCG CGCGGCTCGG GGGCGCAGGG ACGGACGGAC AGCGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016024--ARM-type_fold
IPR000210--BTB/POZ_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0045600--P:positive regulation of fat cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

KEGG

mmu:207259

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001546	Ailuropoda melanoleuca	92.17	0.00e+00	750.00
IUUC-Aca-005243	Anolis carolinensis	70.69	0.00e+00	780.00
IUUC-Ame-010701	Astyanax mexicanus	61.56	2.00e-106	379.00
IUUC-Bta-013295	Bos taurus	92.25	0.00e+00	988.00
IUUC-Cja-018739	Callithrix jacchus	93.71	0.00e+00	1002.00
IUUC-Cfa-020852	Canis familiaris	91.00	0.00e+00	923.00
IUUC-Cpo-021909	Cavia porcellus	93.39	0.00e+00	1013.00
IUUC-Csa-023671	Chlorocebus sabaeus	93.71	0.00e+00	1000.00
IUUC-Dre-027794	Danio rerio	60.60	4.00e-161	561.00
IUUC-Dno-029000	Dasypus novemcinctus	91.72	0.00e+00	775.00
IUUC-Dor-030312	Dipodomys ordii	91.28	0.00e+00	950.00
IUUC-Ete-032624	Echinops telfairi	82.34	3.00e-165	574.00
IUUC-Eca-033481	Equus caballus	94.02	0.00e+00	1002.00
IUUC-Eeu-035288	Erinaceus europaeus	81.91	4.00e-165	574.00
IUUC-Fca-036011	Felis catus	91.61	0.00e+00	980.00
IUUC-Fal-036885	Ficedula albicollis	66.99	0.00e+00	764.00
IUUC-Gmo-039261	Gadus morhua	85.23	2.00e-77	283.00
IUUC-Gga-040337	Gallus gallus	72.90	0.00e+00	810.00
IUUC-Gac-042323	Gasterosteus aculeatus	85.54	1.00e-86	313.00
IUUC-Ggo-045440	Gorilla gorilla	93.86	0.00e+00	998.00
IUUC-Hsa-045829	Homo sapiens	94.18	0.00e+00	1002.00
IUUC-Itr-048052	Ictidomys tridecemlineatus	94.51	0.00e+00	988.00
IUUC-Lch-049875	Latimeria chalumnae	61.19	0.00e+00	704.00
IUUC-Loc-052483	Lepisosteus oculatus	53.48	4.00e-107	382.00
IUUC-Laf-054036	Loxodonta africana	93.21	0.00e+00	959.00
IUUC-Meu-056614	Macropus eugenii	86.45	0.00e+00	973.00
IUUC-Mga-060118	Meleagris gallopavo	71.29	2.00e-143	501.00
IUUC-Mdo-062777	Monodelphis domestica	87.58	0.00e+00	986.00
IUUC-Mpu-066631	Mustela putorius furo	93.38	0.00e+00	1002.00
IUUC-Mlu-067842	Myotis lucifugus	92.58	0.00e+00	996.00
IUUC-Nle-069214	Nomascus leucogenys	93.38	0.00e+00	998.00
IUUC-Opr-071188	Ochotona princeps	86.24	0.00e+00	931.00
IUUC-Ont-071774	Oreochromis niloticus	86.47	5.00e-91	328.00
IUUC-Oan-072960	Ornithorhynchus anatinus	78.22	5.00e-156	543.00
IUUC-Ocu-074040	Oryctolagus cuniculus	88.68	0.00e+00	914.00
IUUC-Ola-087532	Oryzias latipes	56.11	3.00e-153	535.00
IUUC-Oga-087996	Otolemur garnettii	91.92	0.00e+00	984.00
IUUC-Oar-090238	Ovis aries	85.11	0.00e+00	884.00
IUUC-Ptr-090742	Pan troglodytes	94.18	0.00e+00	1002.00
IUUC-Pan-092309	Papio anubis	93.71	0.00e+00	999.00
IUUC-Psi-093613	Pelodiscus sinensis	73.71	0.00e+00	850.00
IUUC-Pfo-096699	Poecilia formosa	50.98	4.00e-139	488.00
IUUC-Pab-097784	Pongo abelii	93.71	0.00e+00	1003.00
IUUC-Pva-102463	Pteropus vampyrus	93.28	0.00e+00	648.00
IUUC-Rno-105055	Rattus norvegicus	97.90	0.00e+00	1006.00
IUUC-Sha-107012	Sarcophilus harrisii	86.77	0.00e+00	957.00
IUUC-Sar-113172	Sorex araneus	87.18	0.00e+00	881.00
IUUC-Ssc-115309	Sus scrofa	86.80	0.00e+00	878.00
IUUC-Tgu-116832	Taeniopygia guttata	72.58	0.00e+00	799.00
IUUC-Tru-117579	Takifugu rubripes	70.37	4.00e-107	382.00
IUUC-Tni-120538	Tetraodon nigroviridis	84.66	7.00e-85	307.00
IUUC-Tbe-127883	Tupaia belangeri	92.54	0.00e+00	644.00
IUUC-Ttr-128944	Tursiops truncatus	93.66	0.00e+00	706.00
IUUC-Xtr-132858	Xenopus tropicalis	64.61	0.00e+00	712.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence