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Tag Content
UUCD2 ID IUUC-Bta-012613
UUCD1 version UUC-BoT-00443
Ensembl Protein ID ENSBTAP00000010745.3
UniProt Accession Q32L60; F1MGY4; TRI13_BOVIN
Genbank Protein ID AAI09750.1
Protein Name E3 ubiquitin-protein ligase TRIM13; Putative tumor suppressor RFP2; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13
Genbank Nucleotide ID DAAA02032918
Gene Name TRIM13; RFP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000008173.3 ENSBTAT00000010745.3 ENSBTAP00000010745.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.50e-09 36.1 10 58
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw....pglknssskefrCPlCr 46
           C+iC++ f+d p+vlpC H f+++Cl+ +    +  +   s  f+CP+Cr
   Q: 10   CPICCSLFDD-PRVLPCSHNFCKKCLEGIlegnVRNSLWRSSPFKCPTCR 58
           ********99.**************966667666666679999******8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
 E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Protein Sequence
(Fasta)
MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG NVRNSLWRSS PFKCPTCRKE 60
TSATGVNSLQ VNYSLKGIVE KYNKIKVSPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR 120
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Protein Fasta Sequence


>IUUC-Bta-012613|E3,RING|Bos taurus
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Nucleotide Sequence
(Fasta)
GGTTGCAGGC GGCGGTTGGA GATACCGGAA GGGCTCCCGC CTGCCCTCAC CCGCGGCCTC 60
CCTCCCCGGG GGAAAAGCGA GCCGCGGAAG GCGGAACAAA GGCGCGGCTC GGCGGGGGAG 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012613|E3,RING|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010942--P:positive regulation of cell death
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051865--P:protein autoubiquitination
GO:0010332--P:response to gamma radiation
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG bta:535190
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002269 Ailuropoda melanoleuca 93.86 0.00e+00 733.00
IUUC-Apl-004168 Anas platyrhynchos 76.23 0.00e+00 630.00
IUUC-Aca-004395 Anolis carolinensis 70.59 9.00e-169 586.00
IUUC-Ame-011325 Astyanax mexicanus 46.75 2.00e-68 253.00
IUUC-Cja-018856 Callithrix jacchus 92.38 0.00e+00 784.00
IUUC-Cfa-021019 Canis familiaris 92.38 0.00e+00 725.00
IUUC-Cpo-021845 Cavia porcellus 91.89 0.00e+00 726.00
IUUC-Csa-023380 Chlorocebus sabaeus 91.89 0.00e+00 733.00
IUUC-Cho-024733 Choloepus hoffmanni 82.81 2.00e-89 322.00
IUUC-Dre-028675 Danio rerio 48.31 1.00e-108 386.00
IUUC-Dno-030018 Dasypus novemcinctus 91.18 0.00e+00 739.00
IUUC-Dor-030599 Dipodomys ordii 90.64 9.00e-131 459.00
IUUC-Ete-033134 Echinops telfairi 87.75 0.00e+00 722.00
IUUC-Eca-033931 Equus caballus 94.84 0.00e+00 731.00
IUUC-Eeu-034903 Erinaceus europaeus 91.40 0.00e+00 717.00
IUUC-Fca-035642 Felis catus 93.86 0.00e+00 728.00
IUUC-Fal-037108 Ficedula albicollis 76.96 0.00e+00 643.00
IUUC-Gga-040903 Gallus gallus 75.00 4.00e-180 624.00
IUUC-Ggo-044635 Gorilla gorilla 92.63 0.00e+00 738.00
IUUC-Hsa-046345 Homo sapiens 92.63 0.00e+00 738.00
IUUC-Itr-048220 Ictidomys tridecemlineatus 90.98 0.00e+00 706.00
IUUC-Lch-050599 Latimeria chalumnae 59.95 1.00e-137 482.00
IUUC-Loc-052378 Lepisosteus oculatus 63.73 8.00e-118 416.00
IUUC-Laf-053332 Loxodonta africana 91.42 0.00e+00 723.00
IUUC-Mcc-054705 Macaca mulatta 91.65 0.00e+00 732.00
IUUC-Meu-056825 Macropus eugenii 84.31 0.00e+00 709.00
IUUC-Mga-059528 Meleagris gallopavo 74.51 0.00e+00 633.00
IUUC-Mmr-060688 Microcebus murinus 93.37 0.00e+00 730.00
IUUC-Mdo-061882 Monodelphis domestica 83.09 0.00e+00 711.00
IUUC-Mmu-064352 Mus musculus 89.19 0.00e+00 742.00
IUUC-Mpu-066712 Mustela putorius furo 91.86 0.00e+00 679.00
IUUC-Mlu-068093 Myotis lucifugus 92.14 0.00e+00 715.00
IUUC-Nle-069310 Nomascus leucogenys 93.12 0.00e+00 739.00
IUUC-Ont-071759 Oreochromis niloticus 59.61 6.00e-111 394.00
IUUC-Oan-073673 Ornithorhynchus anatinus 81.62 0.00e+00 701.00
IUUC-Ocu-074192 Oryctolagus cuniculus 92.87 0.00e+00 738.00
IUUC-Ola-087424 Oryzias latipes 59.28 2.00e-109 389.00
IUUC-Oga-088808 Otolemur garnettii 93.12 0.00e+00 736.00
IUUC-Oar-089553 Ovis aries 99.02 0.00e+00 767.00
IUUC-Ptr-090518 Pan troglodytes 92.38 0.00e+00 734.00
IUUC-Pan-092781 Papio anubis 91.40 0.00e+00 729.00
IUUC-Psi-093914 Pelodiscus sinensis 75.31 0.00e+00 631.00
IUUC-Pfo-096346 Poecilia formosa 56.85 7.00e-111 394.00
IUUC-Pca-100914 Procavia capensis 89.46 0.00e+00 735.00
IUUC-Pva-102728 Pteropus vampyrus 93.12 0.00e+00 727.00
IUUC-Rno-105922 Rattus norvegicus 88.70 0.00e+00 686.00
IUUC-Sha-107124 Sarcophilus harrisii 84.31 0.00e+00 724.00
IUUC-Sar-113607 Sorex araneus 89.19 0.00e+00 698.00
IUUC-Ssc-116355 Sus scrofa 96.07 0.00e+00 748.00
IUUC-Tgu-116476 Taeniopygia guttata 76.72 0.00e+00 639.00
IUUC-Tru-118737 Takifugu rubripes 59.93 3.00e-112 398.00
IUUC-Tsy-118908 Tarsius syrichta 92.63 0.00e+00 750.00
IUUC-Tbe-127258 Tupaia belangeri 95.09 0.00e+00 743.00
IUUC-Vpa-130138 Vicugna pacos 95.09 0.00e+00 744.00
IUUC-Xtr-132100 Xenopus tropicalis 60.73 3.00e-138 484.00
Created Date 25-Jun-2017

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