iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116291

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU915729

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000014780.3	ENSSSCT00000016131.3	ENSSSCP00000015699.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.00e-08	33.9	16	55
E3 activity/RING/U-box	9.90e-10	38.6	12	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+++ + p++  CgH f+++C+  +      + +   CP+Cr
   Q: 16   CSICLDPMVE-PVSIECGHSFCQECISEV-----GKDGGSVCPVCR 55
           *********9.***************999.....7899999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           +e  C+I l++M +Pv +++G+++ +++I +  ++gg+ cPv+rq++  ++l Pn  + ++++
   Q: 12   DEVTCSICLDPMVEPVSIECGHSFCQECISEVGKDGGSVCPVCRQHFLLRNLRPNRQVANMVD 74
           7889***************************99**********************99888776 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MASALPLARM WDEVTCSICL DPMVEPVSIE CGHSFCQECI SEVGKDGGSV CPVCRQHFLL 60
RNLRPNRQVA NMVDNLKEMS QGVKEGPQWE LCAVHGEKLH LFCKDDGKVL CWVCSQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCAGACTT GCGCTCGACG GGAAATGCGG GAAATCGAAA GTGAAACTTG GAGCCAGCTA 60
TTATCTGCGG AGTCCCTTGA AAAGGTGAGT GGATTCACGA ACTCGGTTAG ACCCGGGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	77.40	0.00e+00	763.00
IUUC-Aca-004891	Anolis carolinensis	42.56	2.00e-98	352.00
IUUC-Bta-013083	Bos taurus	76.65	0.00e+00	714.00
IUUC-Bol-016180	Brassica oleracea	42.00	1.00e-09	56.60
IUUC-Cja-019002	Callithrix jacchus	76.50	0.00e+00	730.00
IUUC-Cfa-020415	Canis familiaris	73.72	0.00e+00	732.00
IUUC-Cpo-021948	Cavia porcellus	68.09	0.00e+00	656.00
IUUC-Csa-023135	Chlorocebus sabaeus	78.42	0.00e+00	684.00
IUUC-Cho-024493	Choloepus hoffmanni	65.73	4.00e-95	340.00
IUUC-Dno-030061	Dasypus novemcinctus	68.60	0.00e+00	669.00
IUUC-Ete-033168	Echinops telfairi	67.90	8.00e-165	572.00
IUUC-Eca-033578	Equus caballus	78.25	0.00e+00	748.00
IUUC-Eeu-034749	Erinaceus europaeus	55.51	7.00e-129	453.00
IUUC-Fca-035468	Felis catus	73.27	0.00e+00	702.00
IUUC-Gma-044304	Glycine max	43.08	4.00e-11	62.00
IUUC-Ggo-045190	Gorilla gorilla	76.50	0.00e+00	703.00
IUUC-Hsa-046583	Homo sapiens	77.14	0.00e+00	707.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	74.89	0.00e+00	686.00
IUUC-Laf-053455	Loxodonta africana	74.22	0.00e+00	674.00
IUUC-Mcc-054609	Macaca mulatta	78.42	0.00e+00	683.00
IUUC-Mmr-061369	Microcebus murinus	72.44	5.00e-177	613.00
IUUC-Mmu-063166	Mus musculus	66.88	1.00e-179	622.00
IUUC-Mpu-066889	Mustela putorius furo	75.43	0.00e+00	746.00
IUUC-Mlu-067647	Myotis lucifugus	76.61	0.00e+00	677.00
IUUC-Nle-069567	Nomascus leucogenys	76.71	0.00e+00	704.00
IUUC-Opr-071178	Ochotona princeps	63.87	3.00e-169	587.00
IUUC-Oar-090413	Ovis aries	81.51	0.00e+00	733.00
IUUC-Ptr-091187	Pan troglodytes	77.14	0.00e+00	707.00
IUUC-Pan-092231	Papio anubis	78.21	0.00e+00	680.00
IUUC-Ppa-095897	Physcomitrella patens	46.43	1.00e-09	57.00
IUUC-Pab-098079	Pongo abelii	73.09	5.00e-141	493.00
IUUC-Pop-099737	Populus trichocarpa	42.86	2.00e-09	57.80
IUUC-Pca-100639	Procavia capensis	70.75	2.00e-141	495.00
IUUC-Pva-102476	Pteropus vampyrus	77.40	0.00e+00	727.00
IUUC-Rno-105054	Rattus norvegicus	66.67	4.00e-164	570.00
IUUC-Sar-113204	Sorex araneus	74.15	0.00e+00	663.00
IUUC-Tsy-118803	Tarsius syrichta	72.67	7.00e-131	460.00
IUUC-Tbe-127337	Tupaia belangeri	58.38	2.00e-102	364.00
IUUC-Ttr-128914	Tursiops truncatus	78.46	0.00e+00	675.00
IUUC-Vpa-130566	Vicugna pacos	77.56	0.00e+00	682.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence