iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021346

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02024165

Gene Name

TRAF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000004243.3	ENSCPOT00000004288.2	ENSCPOP00000003828.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	89.42	0.00e+00	926.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MAAASVTPPG SLDLLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLNS 60
ILSSGPQNCA ACVQEGIYEE GVSILETSSA FPDNAARREV ESLPAICPNE GCTWKGTLKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCAG CCAGTGTGAC CCCACCGGGC TCCCTGGACC TTCTGCAGCC TGGCTTTTCC 60
AAGACCCTCC TGGGGACCAA GCTCGAGGCC AAGTACCTGT GCTCCGCCTG TAGAAACGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002344	Ailuropoda melanoleuca	84.89	0.00e+00	891.00
IUUC-Apl-004202	Anas platyrhynchos	73.17	0.00e+00	810.00
IUUC-Aca-005029	Anolis carolinensis	58.28	4.00e-146	510.00
IUUC-Ame-011841	Astyanax mexicanus	55.40	0.00e+00	646.00
IUUC-Bta-013180	Bos taurus	84.57	0.00e+00	880.00
IUUC-Cja-019813	Callithrix jacchus	88.62	0.00e+00	922.00
IUUC-Cfa-021205	Canis familiaris	88.02	0.00e+00	888.00
IUUC-Csa-023809	Chlorocebus sabaeus	87.67	0.00e+00	806.00
IUUC-Dre-027669	Danio rerio	57.74	2.00e-176	612.00
IUUC-Dno-029458	Dasypus novemcinctus	80.81	0.00e+00	862.00
IUUC-Dor-030338	Dipodomys ordii	87.82	0.00e+00	842.00
IUUC-Eca-034401	Equus caballus	86.05	0.00e+00	912.00
IUUC-Eeu-034668	Erinaceus europaeus	92.76	1.00e-82	300.00
IUUC-Fca-036057	Felis catus	84.13	0.00e+00	895.00
IUUC-Fal-037560	Ficedula albicollis	72.64	0.00e+00	733.00
IUUC-Gmo-038964	Gadus morhua	62.03	0.00e+00	665.00
IUUC-Gga-040425	Gallus gallus	74.00	0.00e+00	808.00
IUUC-Gac-041908	Gasterosteus aculeatus	63.49	0.00e+00	670.00
IUUC-Ggo-044606	Gorilla gorilla	82.04	0.00e+00	835.00
IUUC-Hsa-046952	Homo sapiens	89.42	0.00e+00	926.00
IUUC-Itr-049016	Ictidomys tridecemlineatus	79.34	0.00e+00	780.00
IUUC-Lch-049571	Latimeria chalumnae	59.07	0.00e+00	701.00
IUUC-Loc-051973	Lepisosteus oculatus	62.98	3.00e-179	621.00
IUUC-Laf-053815	Loxodonta africana	82.51	0.00e+00	838.00
IUUC-Mcc-054888	Macaca mulatta	89.42	0.00e+00	924.00
IUUC-Meu-056547	Macropus eugenii	71.23	0.00e+00	639.00
IUUC-Mga-059819	Meleagris gallopavo	74.85	0.00e+00	773.00
IUUC-Mdo-062570	Monodelphis domestica	78.29	0.00e+00	830.00
IUUC-Mmu-063133	Mus musculus	88.22	0.00e+00	885.00
IUUC-Mpu-065802	Mustela putorius furo	84.77	0.00e+00	886.00
IUUC-Nle-070155	Nomascus leucogenys	89.42	0.00e+00	931.00
IUUC-Opr-070856	Ochotona princeps	81.58	2.00e-104	372.00
IUUC-Ont-071930	Oreochromis niloticus	63.91	0.00e+00	705.00
IUUC-Ola-087397	Oryzias latipes	60.52	0.00e+00	686.00
IUUC-Oga-088109	Otolemur garnettii	88.22	0.00e+00	916.00
IUUC-Oar-090310	Ovis aries	75.34	0.00e+00	780.00
IUUC-Ptr-090643	Pan troglodytes	89.62	0.00e+00	931.00
IUUC-Pan-091933	Papio anubis	89.22	0.00e+00	921.00
IUUC-Psi-093681	Pelodiscus sinensis	71.96	0.00e+00	770.00
IUUC-Pfo-096148	Poecilia formosa	60.52	0.00e+00	689.00
IUUC-Pab-098631	Pongo abelii	89.62	0.00e+00	931.00
IUUC-Pca-100582	Procavia capensis	65.20	1.00e-84	306.00
IUUC-Pva-102396	Pteropus vampyrus	74.05	0.00e+00	743.00
IUUC-Rno-106120	Rattus norvegicus	87.03	0.00e+00	866.00
IUUC-Sha-106493	Sarcophilus harrisii	79.88	0.00e+00	847.00
IUUC-Sar-113570	Sorex araneus	93.37	3.00e-100	358.00
IUUC-Ssc-115843	Sus scrofa	83.65	0.00e+00	894.00
IUUC-Tgu-117144	Taeniopygia guttata	69.49	0.00e+00	691.00
IUUC-Tru-117853	Takifugu rubripes	61.19	0.00e+00	685.00
IUUC-Tni-120256	Tetraodon nigroviridis	64.27	0.00e+00	711.00
IUUC-Tbe-127943	Tupaia belangeri	66.33	8.00e-96	343.00
IUUC-Ttr-129246	Tursiops truncatus	87.50	0.00e+00	890.00
IUUC-Xtr-132279	Xenopus tropicalis	59.60	8.00e-172	596.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence