iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004134

Ensembl Protein ID

ENSAPLP00000013699.1

UniProt Accession

U3J2H2; U3J2H2_ANAPL

Genbank Protein ID

ENSAPLP00000013699

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADON01079211

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000013851.1	ENSAPLT00000014461.1	ENSAPLP00000013699.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/SH3	80.55	0.00e+00	734.00	IUUC-Hsa-047039

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

GDGGVQKGEK LRVLEESGEW WRAQSLTTGQ EGLIPYNFVA MVNSLEPEPW FFKNLSRKDA 60
ERLLASGNTH GSFLIRESET SKGSYSLSVR DFDQNQGETV KHYKIRNMDN GGYYISPRVT 120

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Nucleotide Sequence
(Fasta)

GGTGATGGGG GTGGNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	75.59	0.00e+00	719.00
IUUC-Atr-002778	Amborella trichopoda	34.20	5.00e-23	103.00
IUUC-Aly-005712	Arabidopsis lyrata	31.49	3.00e-19	90.50
IUUC-Ath-007146	Arabidopsis thaliana	31.35	2.00e-22	100.00
IUUC-Bta-013264	Bos taurus	80.09	0.00e+00	729.00
IUUC-Bdi-014122	Brachypodium distachyon	29.69	4.00e-21	96.70
IUUC-Cfa-021161	Canis familiaris	74.73	0.00e+00	713.00
IUUC-Cpo-022492	Cavia porcellus	80.32	0.00e+00	732.00
IUUC-Dno-029365	Dasypus novemcinctus	77.12	0.00e+00	692.00
IUUC-Dor-030892	Dipodomys ordii	75.70	0.00e+00	722.00
IUUC-Eca-033325	Equus caballus	77.85	0.00e+00	703.00
IUUC-Eeu-035004	Erinaceus europaeus	73.17	2.00e-156	545.00
IUUC-Fca-035908	Felis catus	80.55	0.00e+00	733.00
IUUC-Gga-040997	Gallus gallus	89.24	0.00e+00	801.00
IUUC-Gma-043628	Glycine max	30.65	5.00e-23	102.00
IUUC-Ggo-045238	Gorilla gorilla	75.37	0.00e+00	717.00
IUUC-Hsa-047039	Homo sapiens	80.55	0.00e+00	734.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	81.01	0.00e+00	740.00
IUUC-Lch-049568	Latimeria chalumnae	78.03	0.00e+00	712.00
IUUC-Laf-054499	Loxodonta africana	75.16	0.00e+00	718.00
IUUC-Mcc-054872	Macaca mulatta	73.96	0.00e+00	652.00
IUUC-Meu-056879	Macropus eugenii	78.00	0.00e+00	707.00
IUUC-Mtr-058765	Medicago truncatula	30.65	8.00e-22	99.00
IUUC-Mga-059971	Meleagris gallopavo	89.86	0.00e+00	799.00
IUUC-Mmr-060740	Microcebus murinus	81.01	0.00e+00	738.00
IUUC-Mdo-062192	Monodelphis domestica	80.09	0.00e+00	731.00
IUUC-Mmu-064241	Mus musculus	80.32	0.00e+00	736.00
IUUC-Mpu-066595	Mustela putorius furo	79.86	0.00e+00	726.00
IUUC-Mlu-067069	Myotis lucifugus	80.32	0.00e+00	730.00
IUUC-Opr-070472	Ochotona princeps	76.41	0.00e+00	719.00
IUUC-Ont-071711	Oreochromis niloticus	70.55	9.00e-180	622.00
IUUC-Ocu-074221	Oryctolagus cuniculus	79.22	0.00e+00	718.00
IUUC-Obr-076585	Oryza brachyantha	31.49	9.00e-21	95.10
IUUC-Ogu-078147	Oryza glumaepatula	29.89	7.00e-22	99.00
IUUC-Olo-081004	Oryza longistaminata	30.07	3.00e-20	93.60
IUUC-Opu-083690	Oryza punctata	29.54	4.00e-20	93.20
IUUC-Oru-084532	Oryza rufipogon	29.89	7.00e-22	99.00
IUUC-Osa-085517	Oryza sativa	29.89	7.00e-22	99.00
IUUC-Ola-087000	Oryzias latipes	69.43	0.00e+00	633.00
IUUC-Oga-088225	Otolemur garnettii	79.86	0.00e+00	726.00
IUUC-Oar-090244	Ovis aries	68.99	0.00e+00	673.00
IUUC-Pan-091804	Papio anubis	80.78	0.00e+00	736.00
IUUC-Psi-093252	Pelodiscus sinensis	76.07	0.00e+00	655.00
IUUC-Pfo-096542	Poecilia formosa	70.36	0.00e+00	642.00
IUUC-Pab-098168	Pongo abelii	81.01	0.00e+00	736.00
IUUC-Rno-105542	Rattus norvegicus	80.09	0.00e+00	735.00
IUUC-Sha-107524	Sarcophilus harrisii	78.72	0.00e+00	719.00
IUUC-Sit-110451	Setaria italica	32.16	9.00e-22	98.60
IUUC-Sly-111528	Solanum lycopersicum	33.33	2.00e-24	107.00
IUUC-Stu-112331	Solanum tuberosum	32.80	2.00e-24	107.00
IUUC-Sar-113235	Sorex araneus	75.19	4.00e-175	607.00
IUUC-Ssc-115624	Sus scrofa	80.09	0.00e+00	728.00
IUUC-Tru-118559	Takifugu rubripes	68.12	3.00e-179	621.00
IUUC-Tae-123192	Triticum aestivum	29.10	2.00e-22	100.00
IUUC-Ttr-129002	Tursiops truncatus	71.52	0.00e+00	664.00
IUUC-Vvi-131057	Vitis vinifera	34.25	2.00e-24	107.00
IUUC-Xtr-132224	Xenopus tropicalis	75.00	0.00e+00	686.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence