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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106148
Ensembl Protein ID YLR417W
UniProt Accession Q06696; D6VZ53; VPS36_YEAST
Genbank Protein ID AAB67493.1; DAA09719.1
Protein Name Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36
Genbank Nucleotide ID U20162; BK006945
Gene Name VPS36; GRD12; VAC3; VPL11; YLR417W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YLR417W YLR417W YLR417W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDBSCOP
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/PH/GLUE GLUE 15029239; 15329733; 15755741; 16615893; 16689637
UBD/ZnF/NZF NZF 15029239; 15329733; 15755741; 16615893; 16689637
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/PH/GLUE 24.05 7.00e-04 42.70 IUUC-Ath-006907
UBD/PH/GLUE 22.29 2.40e-01 35.00 IUUC-Hsa-046228
UBD/PH/GLUE 21.66 9.20e-02 36.20 IUUC-Mmu-063115
UBD/ZnF/NZF 23.37 1.00e-30 129.00 IUUC-Spo-108225
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.
 Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Involved in the trafficking of the plasma membrane ATPase. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes.
Protein Sequence
(Fasta)
MEYWHYVETT SSGQPLLREG EKDIFIDQSV GLYHGKSKIL QRQRGRIFLT SQRIIYIDDA 60
KPTQNSLGLE LDDLAYVNYS SGFLTRSPRL ILFFKDPSSK DELGKSAETA SADVVSTWVC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106148|UBD,GLUE;UBD,NZF|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGTACT GGCATTATGT GGAAACTACG TCATCGGGCC AACCTCTTCT TCGAGAAGGT 60
GAAAAAGATA TCTTTATCGA TCAGTCCGTA GGTCTTTACC ATGGCAAATC TAAGATTCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106148|UBD,GLUE;UBD,NZF|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR031558--Vps36-NZF-N
IPR011991--WHTH_DNA-bd_dom
IPR001876--Znf_RanBP2
PROSITE

PS51495--GLUE
Pfam

PF04157--EAP30
PF16988--Vps36-NZF-N
PF11605--Vps36_ESCRT-II
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0000814--C:ESCRT II complex
GO:0031902--C:late endosome membrane
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:1904669--P:ATP export
GO:0032258--P:CVT pathway
GO:0016236--P:macroautophagy
GO:0000433--P:negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0045053--P:protein retention in Golgi apparatus
GO:0006623--P:protein targeting to vacuole
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG sce:YLR417W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000963 Aegilops tauschii 32.65 2.00e-03 33.50
IUUC-Aml-002313 Ailuropoda melanoleuca 21.66 3.00e-04 37.70
IUUC-Apl-003218 Anas platyrhynchos 22.88 8.00e-04 36.20
IUUC-Aca-005332 Anolis carolinensis 61.11 2.20e-02 32.30
IUUC-Aly-006398 Arabidopsis lyrata 24.05 8.00e-06 42.70
IUUC-Ath-006907 Arabidopsis thaliana 24.05 1.00e-05 42.40
IUUC-Ago-007840 Ashbya gossypii 46.07 1.00e-142 497.00
IUUC-Acl-008117 Aspergillus clavatus 24.60 6.00e-38 150.00
IUUC-Afl-008595 Aspergillus flavus 25.74 1.00e-42 165.00
IUUC-Afu-008918 Aspergillus fumigatus 23.08 4.00e-23 100.00
IUUC-Ani-009206 Aspergillus nidulans 24.43 3.00e-40 157.00
IUUC-Ang-009784 Aspergillus niger 25.00 8.00e-36 142.00
IUUC-Aor-010126 Aspergillus oryzae 25.13 4.00e-38 150.00
IUUC-Ate-010303 Aspergillus terreus 24.29 2.00e-38 151.00
IUUC-Ame-011190 Astyanax mexicanus 21.57 5.00e-04 37.00
IUUC-Bgr-011979 Blumeria graminis 26.36 5.00e-30 123.00
IUUC-Bta-012661 Bos taurus 21.66 3.00e-04 37.40
IUUC-Bci-013982 Botrytis cinerea 23.83 1.00e-34 139.00
IUUC-Bdi-014753 Brachypodium distachyon 25.00 2.00e-06 44.70
IUUC-Bol-015465 Brassica oleracea 24.05 1.00e-05 42.40
IUUC-Bra-016794 Brassica rapa 24.05 1.00e-05 42.70
IUUC-Cel-018514 Caenorhabditis elegans 20.23 5.00e-03 33.10
IUUC-Cja-019285 Callithrix jacchus 21.66 5.00e-04 36.60
IUUC-Cfa-020860 Canis familiaris 29.63 2.00e-03 37.00
IUUC-Cpo-022005 Cavia porcellus 21.66 4.00e-04 37.00
IUUC-Cre-022802 Chlamydomonas reinhardtii 33.33 3.10e-02 33.50
IUUC-Csa-023520 Chlorocebus sabaeus 22.29 1.00e-03 35.80
IUUC-Cho-024957 Choloepus hoffmanni 21.66 5.00e-04 36.60
IUUC-Cin-025456 Ciona intestinalis 50.00 1.20e-01 28.50
IUUC-Csv-025942 Ciona savignyi 23.64 4.00e-03 33.50
IUUC-Cgl-026558 Colletotrichum gloeosporioides 23.94 1.00e-34 139.00
IUUC-Cne-026915 Cryptococcus neoformans 27.21 4.00e-06 43.90
IUUC-Cme-027259 Cyanidioschyzon merolae 32.31 1.00e-01 29.30
IUUC-Dre-027753 Danio rerio 21.57 6.00e-04 36.60
IUUC-Dno-029448 Dasypus novemcinctus 24.65 1.00e-03 37.00
IUUC-Dor-030605 Dipodomys ordii 61.11 4.80e-02 31.20
IUUC-Dse-031368 Dothistroma septosporum 24.55 2.00e-35 141.00
IUUC-Dme-031784 Drosophila melanogaster 61.11 6.90e-02 30.80
IUUC-Ete-032260 Echinops telfairi 30.67 3.50e-02 31.60
IUUC-Eca-033937 Equus caballus 21.46 2.00e-04 37.70
IUUC-Eeu-034483 Erinaceus europaeus 21.02 2.00e-03 35.00
IUUC-Fca-036018 Felis catus 24.07 3.00e-03 35.80
IUUC-Fal-036743 Ficedula albicollis 21.66 3.00e-04 37.70
IUUC-Fox-037685 Fusarium oxysporum 25.46 3.00e-30 124.00
IUUC-Fso-038421 Fusarium solani 25.59 9.00e-35 139.00
IUUC-Gmo-038762 Gadus morhua 31.82 9.00e-03 33.90
IUUC-Ggr-039763 Gaeumannomyces graminis 24.81 1.00e-30 126.00
IUUC-Gga-040556 Gallus gallus 21.88 1.00e-03 35.80
IUUC-Gac-041556 Gasterosteus aculeatus 28.92 1.10e-02 34.30
IUUC-Gma-044185 Glycine max 22.16 4.00e-06 43.90
IUUC-Ggo-044849 Gorilla gorilla 22.29 1.00e-03 35.80
IUUC-Hsa-046228 Homo sapiens 22.29 1.00e-03 35.80
IUUC-Hvu-047244 Hordeum vulgare 21.33 8.00e-03 33.10
IUUC-Itr-048692 Ictidomys tridecemlineatus 22.29 1.00e-03 35.80
IUUC-Kpa-049240 Komagataella pastoris 26.29 1.00e-34 138.00
IUUC-Lch-050060 Latimeria chalumnae 27.83 2.00e-04 41.20
IUUC-Lpe-051363 Leersia perrieri 22.50 1.00e-05 42.40
IUUC-Loc-052866 Lepisosteus oculatus 22.52 2.00e-03 35.00
IUUC-Lma-053139 Leptosphaeria maculans 24.70 5.00e-30 124.00
IUUC-Laf-053881 Loxodonta africana 21.02 3.00e-03 33.90
IUUC-Mcc-055158 Macaca mulatta 22.29 1.00e-03 35.80
IUUC-Meu-056126 Macropus eugenii 22.64 8.00e-03 32.30
IUUC-Mor-057092 Magnaporthe oryzae 23.73 1.00e-31 129.00
IUUC-Mpo-057629 Magnaporthe poae 25.97 3.00e-08 50.40
IUUC-Mtr-058039 Medicago truncatula 24.36 1.00e-06 45.80
IUUC-Mla-058913 Melampsora laricipopulina 22.32 2.00e-17 82.00
IUUC-Mga-059956 Meleagris gallopavo 21.66 1.00e-03 35.40
IUUC-Mvi-060570 Microbotryum violaceum 41.18 2.00e-10 58.90
IUUC-Mmr-061769 Microcebus murinus 22.29 1.00e-03 35.80
IUUC-Mdo-062558 Monodelphis domestica 29.07 2.00e-04 37.70
IUUC-Mmu-063115 Mus musculus 21.66 5.00e-04 36.60
IUUC-Mac-064979 Musa acuminata 24.71 4.00e-07 47.40
IUUC-Mpu-066215 Mustela putorius furo 24.04 9.00e-03 34.30
IUUC-Mlu-067474 Myotis lucifugus 21.66 4.00e-04 37.40
IUUC-Nfi-068588 Neosartorya fischeri 23.05 7.00e-33 133.00
IUUC-Ncr-068855 Neurospora crassa 23.40 3.00e-30 124.00
IUUC-Nle-069660 Nomascus leucogenys 22.29 1.00e-03 35.40
IUUC-Opr-070695 Ochotona princeps 21.66 4.00e-04 37.00
IUUC-Ont-071837 Oreochromis niloticus 21.05 6.70e-02 29.60
IUUC-Oan-072903 Ornithorhynchus anatinus 20.36 2.00e-04 38.10
IUUC-Ocu-074833 Oryctolagus cuniculus 21.66 4.00e-04 37.00
IUUC-Oba-075899 Oryza barthii 23.53 1.00e-05 41.60
IUUC-Obr-076125 Oryza brachyantha 23.17 6.00e-05 40.00
IUUC-Ogl-077538 Oryza glaberrima 42.86 3.00e-03 34.30
IUUC-Ogu-078272 Oryza glumaepatula 22.50 1.00e-05 42.00
IUUC-Oin-079158 Oryza indica 23.53 2.00e-05 41.60
IUUC-Olo-080496 Oryza longistaminata 23.53 1.00e-05 41.20
IUUC-Ome-081440 Oryza meridionalis 25.56 3.00e-05 40.40
IUUC-Oni-083069 Oryza nivara 23.53 2.00e-05 41.60
IUUC-Opu-083838 Oryza punctata 25.56 2.00e-05 41.20
IUUC-Oru-084377 Oryza rufipogon 22.50 1.00e-05 42.00
IUUC-Osa-085976 Oryza sativa 22.50 1.00e-05 42.00
IUUC-Ola-086431 Oryzias latipes 22.56 8.00e-03 32.70
IUUC-Olu-087789 Ostreococcus lucimarinus 28.57 4.00e-05 39.30
IUUC-Oga-089152 Otolemur garnettii 21.66 7.00e-04 36.20
IUUC-Oar-089198 Ovis aries 21.66 3.00e-04 37.40
IUUC-Ptr-091123 Pan troglodytes 22.29 1.00e-03 35.80
IUUC-Pan-092866 Papio anubis 22.29 5.00e-04 36.60
IUUC-Psi-093384 Pelodiscus sinensis 21.02 2.00e-03 34.70
IUUC-Pno-094773 Phaeosphaeria nodorum 27.06 2.00e-23 102.00
IUUC-Ppa-095753 Physcomitrella patens 24.00 7.00e-05 39.70
IUUC-Pfo-096028 Poecilia formosa 21.05 3.70e-02 30.40
IUUC-Pop-098915 Populus trichocarpa 21.43 1.00e-04 38.90
IUUC-Pca-100422 Procavia capensis 22.93 1.00e-04 38.50
IUUC-Ppe-101564 Prunus persica 23.78 3.00e-05 40.80
IUUC-Pgr-103670 Puccinia graminis 21.78 4.00e-18 84.70
IUUC-Ptt-103958 Puccinia triticina 24.59 7.00e-02 29.60
IUUC-Pte-104343 Pyrenophora teres 25.62 3.00e-41 160.00
IUUC-Pyt-104554 Pyrenophora triticirepentis 23.03 2.00e-30 125.00
IUUC-Rno-105775 Rattus norvegicus 21.66 4.00e-04 37.00
IUUC-Sha-106468 Sarcophilus harrisii 21.66 3.00e-03 33.90
IUUC-Sja-107850 Schizosaccharomyces japonicus 29.15 7.00e-20 89.70
IUUC-Spo-108225 Schizosaccharomyces pombe 23.37 1.00e-31 129.00
IUUC-Ssl-108412 Sclerotinia sclerotiorum 20.47 9.00e-16 76.30
IUUC-Smo-109001 Selaginella moellendorffii 23.68 3.00e-08 50.80
IUUC-Sit-110126 Setaria italica 22.44 4.00e-05 40.40
IUUC-Sly-110884 Solanum lycopersicum 22.09 1.00e-05 42.40
IUUC-Stu-112573 Solanum tuberosum 21.47 4.00e-05 40.80
IUUC-Sar-113207 Sorex araneus 61.11 6.30e-02 30.80
IUUC-Sbi-114331 Sorghum bicolor 32.65 3.00e-03 34.30
IUUC-Sre-115135 Sporisorium reilianum 27.71 1.00e-15 76.60
IUUC-Ssc-116158 Sus scrofa 21.66 3.00e-04 37.40
IUUC-Tgu-116962 Taeniopygia guttata 21.66 3.00e-04 37.40
IUUC-Tru-118000 Takifugu rubripes 29.91 4.10e-02 32.00
IUUC-Tsy-119508 Tarsius syrichta 55.56 8.80e-02 30.40
IUUC-Tni-120004 Tetraodon nigroviridis 43.33 3.00e-03 34.30
IUUC-Tca-121097 Theobroma cacao 24.05 1.00e-05 42.40
IUUC-Tre-122075 Trichoderma reesei 24.37 8.00e-31 126.00
IUUC-Tvi-122623 Trichoderma virens 24.96 3.00e-37 147.00
IUUC-Tae-123728 Triticum aestivum 21.71 5.00e-05 40.40
IUUC-Tur-125988 Triticum urartu 22.50 7.00e-05 39.70
IUUC-Tme-126936 Tuber melanosporum 23.81 1.00e-37 149.00
IUUC-Ttr-128160 Tursiops truncatus 21.66 3.00e-04 37.70
IUUC-Uma-129428 Ustilago maydis 24.76 4.00e-19 87.80
IUUC-Vda-129877 Verticillium dahliae 23.43 4.00e-26 110.00
IUUC-Vpa-130358 Vicugna pacos 21.02 1.00e-03 35.00
IUUC-Vvi-131406 Vitis vinifera 23.68 2.00e-05 42.00
IUUC-Xtr-132548 Xenopus tropicalis 20.59 4.00e-03 33.90
IUUC-Xma-133352 Xiphophorus maculatus 21.05 3.70e-02 30.40
IUUC-Yli-134466 Yarrowia lipolytica 31.58 4.00e-29 120.00
IUUC-Zma-135081 Zea mays 22.16 4.00e-04 37.40
Created Date 25-Jun-2017

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