iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048549

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTP01020178

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000005418.2	ENSSTOT00000005442.2	ENSSTOP00000004869.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.10e-93	311.6	148	689

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 148  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 231
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................a 130
           qqD+qEfl++l+dql+eelk+              +++++++e++e d+s ++de                                 +
   Q: 232  QQDTQEFLRCLMDQLHEELKEpavaatvgltdtrdSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrsgggsqaeaellipdE 320
           *******************9955544444444433333333333333333333336666555555555555555554444444444441 PP
   S: 131  eekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.................................. 185
                                                              ++ +                                  
   Q: 321  -------------------------------------------------AGRAISekermkdrkfswgqqranseqldedadvdtamaa 360
           .................................................3222223333333333333333333345555555555555 PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 361  lddqpaeaqppsppsispcrtpepdndahlrsssrpcspvhhreghaklsssppraspvrmgpsyvlkkaqalstgtapchtpsdllcs 449
           55555556666677777888888888888888888888888999999999999999999999999999999999999999999999999 PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 450  sevlcgrpgeghqdpgpftgrgaitssrtwwgrsrlvhllaklarwacgasglsrrcqsppilsgpalvaltafclcrfvvsctpswfw 538
           999999999999999999999999999999999******************************************************** PP
   S: 186  ....slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspe 269
               +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf  ++e + + ki+++v+fple Ldl+pf+++++
   Q: 539  gpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF--RHEVMYSFKISSHVSFPLEgLDLRPFLAKEC 625
           ********************************************************..9999*************************** PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           ++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v+    ++aYvlfY++
   Q: 626  TSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQH---AEAYVLFYRK 689
           999..9**************************78999*******************...********98 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MGDPRDFCPH LDSIGEVTKE DLLLKSKGSC QSCGVAGPNL WACLQVACPY VGCGESFADH 60
STIHAQVETK TKTTNICSIQ LVVRVLNFSL CSCFFPDILE IKLFIIANKK YKQDSPLPSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTGACC CCAGGGACTT CTGCCCTCAT CTGGACTCCA TAGGGGAAGT GACCAAAGAG 60
GACTTGCTGC TCAAATCTAA GGTAAAGGGG CAGACCTTAT GACCAGGGCC CATGCCCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	79.68	0.00e+00	1377.00
IUUC-Apl-003351	Anas platyrhynchos	74.12	0.00e+00	1295.00
IUUC-Aca-005077	Anolis carolinensis	69.74	0.00e+00	1002.00
IUUC-Ame-011777	Astyanax mexicanus	66.21	0.00e+00	1112.00
IUUC-Bta-013063	Bos taurus	80.93	0.00e+00	1370.00
IUUC-Cja-019868	Callithrix jacchus	81.84	0.00e+00	1427.00
IUUC-Cfa-020761	Canis familiaris	80.53	0.00e+00	1397.00
IUUC-Cpo-022267	Cavia porcellus	75.11	0.00e+00	1278.00
IUUC-Csa-024251	Chlorocebus sabaeus	82.36	0.00e+00	1436.00
IUUC-Cho-024483	Choloepus hoffmanni	96.23	2.00e-123	436.00
IUUC-Csv-025889	Ciona savignyi	44.64	1.00e-35	142.00
IUUC-Dre-028061	Danio rerio	63.96	0.00e+00	991.00
IUUC-Dno-029423	Dasypus novemcinctus	81.39	0.00e+00	1407.00
IUUC-Dor-030877	Dipodomys ordii	77.41	0.00e+00	888.00
IUUC-Ete-032802	Echinops telfairi	73.45	6.00e-118	418.00
IUUC-Eca-034283	Equus caballus	79.96	0.00e+00	1368.00
IUUC-Eeu-034620	Erinaceus europaeus	73.59	0.00e+00	905.00
IUUC-Fca-036357	Felis catus	80.95	0.00e+00	1392.00
IUUC-Fal-037411	Ficedula albicollis	74.09	0.00e+00	1297.00
IUUC-Gga-041101	Gallus gallus	74.52	0.00e+00	1293.00
IUUC-Gac-041315	Gasterosteus aculeatus	63.77	0.00e+00	1100.00
IUUC-Ggo-045600	Gorilla gorilla	82.35	0.00e+00	1397.00
IUUC-Hsa-045825	Homo sapiens	82.90	0.00e+00	1412.00
IUUC-Loc-052574	Lepisosteus oculatus	66.95	0.00e+00	1162.00
IUUC-Laf-054428	Loxodonta africana	80.54	0.00e+00	1362.00
IUUC-Mcc-055736	Macaca mulatta	82.36	0.00e+00	1434.00
IUUC-Mga-059781	Meleagris gallopavo	73.89	0.00e+00	1284.00
IUUC-Mdo-063048	Monodelphis domestica	75.03	0.00e+00	1257.00
IUUC-Mmu-064079	Mus musculus	79.96	0.00e+00	1363.00
IUUC-Mpu-066616	Mustela putorius furo	79.42	0.00e+00	1426.00
IUUC-Mlu-067294	Myotis lucifugus	79.89	0.00e+00	1350.00
IUUC-Nle-070015	Nomascus leucogenys	81.53	0.00e+00	1370.00
IUUC-Opr-070328	Ochotona princeps	80.45	0.00e+00	1400.00
IUUC-Ont-071464	Oreochromis niloticus	65.68	0.00e+00	1088.00
IUUC-Ocu-074630	Oryctolagus cuniculus	77.60	0.00e+00	1286.00
IUUC-Ola-087240	Oryzias latipes	64.38	0.00e+00	1062.00
IUUC-Oga-088761	Otolemur garnettii	81.36	0.00e+00	1409.00
IUUC-Oar-089490	Ovis aries	75.24	0.00e+00	1218.00
IUUC-Ptr-091662	Pan troglodytes	82.68	0.00e+00	1410.00
IUUC-Pan-092199	Papio anubis	81.97	0.00e+00	1424.00
IUUC-Psi-093726	Pelodiscus sinensis	74.68	0.00e+00	1292.00
IUUC-Pab-098632	Pongo abelii	82.20	0.00e+00	1403.00
IUUC-Rno-105215	Rattus norvegicus	79.83	0.00e+00	1367.00
IUUC-Sha-106601	Sarcophilus harrisii	74.39	0.00e+00	1258.00
IUUC-Ssc-115533	Sus scrofa	79.13	0.00e+00	1347.00
IUUC-Tgu-117364	Taeniopygia guttata	74.22	0.00e+00	1281.00
IUUC-Tru-117770	Takifugu rubripes	63.25	0.00e+00	1065.00
IUUC-Ttr-128732	Tursiops truncatus	80.82	0.00e+00	1383.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence