iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000031534.1	ENSXETT00000065210.1	ENSXETP00000064077.1
ENSXETG00000031534.1	ENSXETT00000061083.1	ENSXETP00000061457.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-80	271.0	415	747

Active Site

Position(s)	Description	Evidence
716	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+f gE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 415  RADLKKKLKVTFMGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSNCHWFSSFKC-----DNYSEFRLVGTLMGLAVYNSITLDI 498
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++l+dl +++pel++ l+e++ + + ++ee  +  tf+v +e++g++k+++LkpgG++ipV
   Q: 499  RFPPCCYKKLLSPpivpcdqnmpvgiaPVTLDDLYQIMPELAHGLNELLCY-DGNVEED-FYSTFQVFQEEFGTIKSYNLKPGGDKIPV 585
           **********999777777777777777*********************99.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l+v++ l+++i +q+ af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++ ++++    l 
   Q: 586  TNQNRKEYVQLYVDFLLNKSIYKQFSAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YLKTDVTVRT---ELG 670
           **********************************************************************77.9999999964...445 PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++       +L  +   s  P      l     v++  + ++ lP ++TCfn+L+LP+Y++k++lk+kL++Ai++++gF+l
   Q: 671  QVVLVLMVILLGMAVAESPFPYLPATLLY---LVVP-GHWKNLLPIAHTCFNQLCLPPYKTKKELKQKLTIAISNAEGFGL 747
           55555678899999999988864433333...3344.47789*************************************98 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MDEEERQRDK LPPILCATSA ASGGMDRGAK GQFSTFSNFI STINQKKEAA GNRNSPTQMV 60
LPNNKNVRDL PPICLDVRQK QCISIDTLPP EMKASILPEP QIPTRNKTLK DFQVDLEKAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAGG AGGAGAGACA GAGAGACAAG CTTCCGCCAA TCCTGTGCGC AACTAGCGCA 60
GCCTCCGGGG TAACTATCTG CCATCCCTCA TCCTCTCCTT CAGGGACTTG TACACCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	79.84	0.00e+00	1216.00
IUUC-Apl-003589	Anas platyrhynchos	79.62	0.00e+00	1176.00
IUUC-Aca-004350	Anolis carolinensis	75.89	0.00e+00	1115.00
IUUC-Acl-008288	Aspergillus clavatus	34.21	9.00e-87	315.00
IUUC-Afl-008402	Aspergillus flavus	32.45	7.00e-81	295.00
IUUC-Afu-008762	Aspergillus fumigatus	33.17	1.00e-83	305.00
IUUC-Ang-009791	Aspergillus niger	34.09	2.00e-83	304.00
IUUC-Aor-009921	Aspergillus oryzae	32.29	5.00e-80	292.00
IUUC-Ate-010295	Aspergillus terreus	30.95	3.00e-89	323.00
IUUC-Ame-010660	Astyanax mexicanus	70.39	3.00e-123	434.00
IUUC-Bta-012945	Bos taurus	78.92	0.00e+00	1186.00
IUUC-Bci-013697	Botrytis cinerea	37.14	7.00e-73	269.00
IUUC-Cja-019263	Callithrix jacchus	77.02	0.00e+00	1162.00
IUUC-Cfa-020486	Canis familiaris	81.24	0.00e+00	1090.00
IUUC-Cpo-021755	Cavia porcellus	78.17	0.00e+00	1196.00
IUUC-Csa-023814	Chlorocebus sabaeus	82.85	0.00e+00	1129.00
IUUC-Cho-024980	Choloepus hoffmanni	63.78	0.00e+00	914.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	40.00	2.00e-87	317.00
IUUC-Dre-028551	Danio rerio	70.07	0.00e+00	1062.00
IUUC-Dno-029497	Dasypus novemcinctus	78.12	0.00e+00	1066.00
IUUC-Dor-030867	Dipodomys ordii	68.86	0.00e+00	978.00
IUUC-Dse-031239	Dothistroma septosporum	30.57	5.00e-79	289.00
IUUC-Ete-032902	Echinops telfairi	67.03	0.00e+00	983.00
IUUC-Eca-033678	Equus caballus	80.00	0.00e+00	1198.00
IUUC-Eeu-035262	Erinaceus europaeus	64.87	0.00e+00	863.00
IUUC-Fca-035590	Felis catus	80.00	0.00e+00	1218.00
IUUC-Fal-037123	Ficedula albicollis	77.08	0.00e+00	1179.00
IUUC-Fso-038388	Fusarium solani	39.48	1.00e-93	338.00
IUUC-Gmo-039553	Gadus morhua	62.03	0.00e+00	766.00
IUUC-Ggr-040110	Gaeumannomyces graminis	38.89	1.00e-89	325.00
IUUC-Gga-040406	Gallus gallus	79.76	0.00e+00	1220.00
IUUC-Gac-042141	Gasterosteus aculeatus	71.80	0.00e+00	1029.00
IUUC-Ggo-045504	Gorilla gorilla	77.11	0.00e+00	1178.00
IUUC-Hsa-045786	Homo sapiens	77.79	0.00e+00	1185.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	74.89	0.00e+00	1020.00
IUUC-Lch-049824	Latimeria chalumnae	80.72	0.00e+00	1027.00
IUUC-Loc-052173	Lepisosteus oculatus	74.70	0.00e+00	1113.00
IUUC-Laf-054017	Loxodonta africana	80.20	0.00e+00	1132.00
IUUC-Mcc-055713	Macaca mulatta	77.82	0.00e+00	1156.00
IUUC-Meu-056212	Macropus eugenii	67.03	5.00e-98	351.00
IUUC-Mla-059187	Melampsora laricipopulina	41.11	4.00e-79	288.00
IUUC-Mga-059884	Meleagris gallopavo	72.99	0.00e+00	1048.00
IUUC-Mmr-061344	Microcebus murinus	79.73	0.00e+00	1177.00
IUUC-Mdo-062653	Monodelphis domestica	79.07	0.00e+00	1172.00
IUUC-Mmu-063775	Mus musculus	76.48	0.00e+00	1096.00
IUUC-Mpu-066069	Mustela putorius furo	80.06	0.00e+00	1107.00
IUUC-Mlu-067925	Myotis lucifugus	78.77	0.00e+00	1161.00
IUUC-Nfi-068439	Neosartorya fischeri	33.00	2.00e-83	304.00
IUUC-Ncr-068903	Neurospora crassa	30.04	3.00e-83	303.00
IUUC-Nle-070046	Nomascus leucogenys	77.78	0.00e+00	1190.00
IUUC-Opr-071085	Ochotona princeps	74.16	8.00e-129	454.00
IUUC-Ont-072126	Oreochromis niloticus	70.45	0.00e+00	1096.00
IUUC-Oan-072933	Ornithorhynchus anatinus	78.40	0.00e+00	1036.00
IUUC-Ocu-073800	Oryctolagus cuniculus	80.36	0.00e+00	1092.00
IUUC-Ola-086988	Oryzias latipes	72.40	0.00e+00	1043.00
IUUC-Oga-088117	Otolemur garnettii	81.69	0.00e+00	957.00
IUUC-Oar-089371	Ovis aries	79.18	0.00e+00	1160.00
IUUC-Ptr-090551	Pan troglodytes	76.44	0.00e+00	1130.00
IUUC-Pan-092067	Papio anubis	78.24	0.00e+00	1162.00
IUUC-Psi-092963	Pelodiscus sinensis	79.54	0.00e+00	1150.00
IUUC-Pfo-096562	Poecilia formosa	67.33	0.00e+00	1048.00
IUUC-Pab-098680	Pongo abelii	78.20	0.00e+00	1189.00
IUUC-Pca-100986	Procavia capensis	72.28	0.00e+00	748.00
IUUC-Pva-102219	Pteropus vampyrus	68.76	0.00e+00	885.00
IUUC-Rno-105270	Rattus norvegicus	75.23	0.00e+00	1100.00
IUUC-Sha-106819	Sarcophilus harrisii	80.16	0.00e+00	1206.00
IUUC-Spo-108271	Schizosaccharomyces pombe	33.15	6.00e-77	282.00
IUUC-Sar-113134	Sorex araneus	72.03	0.00e+00	1041.00
IUUC-Ssc-115441	Sus scrofa	79.86	0.00e+00	1179.00
IUUC-Tgu-117166	Taeniopygia guttata	77.39	0.00e+00	1142.00
IUUC-Tsy-118898	Tarsius syrichta	73.84	0.00e+00	910.00
IUUC-Tvi-122644	Trichoderma virens	37.07	1.00e-84	308.00
IUUC-Tme-127004	Tuber melanosporum	33.08	3.00e-92	333.00
IUUC-Tbe-127292	Tupaia belangeri	65.07	0.00e+00	883.00
IUUC-Ttr-128352	Tursiops truncatus	76.16	0.00e+00	1122.00
IUUC-Vpa-130218	Vicugna pacos	82.37	0.00e+00	925.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence