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Tag Content
UUCD2 ID IUUC-Ssc-115428
UUCD1 version UUC-SuS-00517
Ensembl Protein ID ENSSSCP00000025173.1
UniProt Accession I3LM52; I3LM52_PIG
Genbank Protein ID ENSSSCP00000025173
Protein Name Histone deacetylase
Genbank Nucleotide ID FP089685
Gene Name HDAC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000024777.1 ENSSSCT00000027033.1 ENSSSCP00000025173.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 92.44 0.00e+00 1659.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
771 N/A {ECO:0000256|PIRSR:PIRSR037911-1}
Organism Sus scrofa
Functional Description
(View)

Functional Description


     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Protein Sequence
(Fasta)
AVDVASALPL QVAPPAVPMD LRLDHQFPLP VTEPGLREQQ LQQELLALKQ KQQLQRQILI 60
AEFQRQHEQL SRQHEAQLHE HIKQQQELLA MKHQQELLEH QRKLERHRQE QELEKQHREQ 120
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Protein Fasta Sequence


>IUUC-Ssc-115428|E3,E3 activity/Other|Sus scrofa
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Nucleotide Sequence
(Fasta)
GCAGTGGATG TGGCCTCGGC GCTGCCTCTG CAAGTGGCTC CCCCGGCGGT GCCCATGGAC 60
CTGCGCCTGG ACCACCAGTT CCCGCTGCCC GTGACGGAGC CCGGCCTCCG GGAGCAGCAG 120
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Nucleotide Fasta Sequence


>IUUC-Ssc-115428|E3,E3 activity/Other|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl
PRINTS

PR01270--HDASUPER
Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002279 Ailuropoda melanoleuca 92.57 0.00e+00 1684.00
IUUC-Apl-003250 Anas platyrhynchos 86.91 0.00e+00 1583.00
IUUC-Aca-004668 Anolis carolinensis 81.82 0.00e+00 1574.00
IUUC-Bta-013215 Bos taurus 94.61 0.00e+00 1701.00
IUUC-Cja-019816 Callithrix jacchus 91.79 0.00e+00 1697.00
IUUC-Cfa-020861 Canis familiaris 92.74 0.00e+00 1662.00
IUUC-Cpo-021562 Cavia porcellus 90.72 0.00e+00 1685.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 51.35 2.00e-53 201.00
IUUC-Csa-023612 Chlorocebus sabaeus 91.55 0.00e+00 1668.00
IUUC-Csv-026359 Ciona savignyi 54.39 2.00e-95 341.00
IUUC-Dre-028284 Danio rerio 86.48 0.00e+00 856.00
IUUC-Dno-029951 Dasypus novemcinctus 90.16 0.00e+00 1587.00
IUUC-Dor-030362 Dipodomys ordii 81.00 0.00e+00 1400.00
IUUC-Dme-031766 Drosophila melanogaster 58.69 3.00e-159 555.00
IUUC-Fca-036187 Felis catus 94.08 0.00e+00 1709.00
IUUC-Gmo-038473 Gadus morhua 76.66 0.00e+00 731.00
IUUC-Gga-040501 Gallus gallus 89.81 0.00e+00 1617.00
IUUC-Gac-042335 Gasterosteus aculeatus 84.55 0.00e+00 835.00
IUUC-Ggo-045380 Gorilla gorilla 91.89 0.00e+00 1665.00
IUUC-Hsa-046925 Homo sapiens 92.37 0.00e+00 1694.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 91.51 0.00e+00 1662.00
IUUC-Lch-050325 Latimeria chalumnae 84.23 0.00e+00 1497.00
IUUC-Loc-052231 Lepisosteus oculatus 80.92 0.00e+00 1460.00
IUUC-Laf-054490 Loxodonta africana 86.00 0.00e+00 1634.00
IUUC-Mcc-055265 Macaca mulatta 91.55 0.00e+00 1671.00
IUUC-Meu-056676 Macropus eugenii 86.71 0.00e+00 747.00
IUUC-Mmr-061633 Microcebus murinus 83.83 0.00e+00 1474.00
IUUC-Mmu-063089 Mus musculus 91.01 0.00e+00 1615.00
IUUC-Mpu-065887 Mustela putorius furo 93.72 0.00e+00 1701.00
IUUC-Mlu-067470 Myotis lucifugus 93.73 0.00e+00 1727.00
IUUC-Nle-069099 Nomascus leucogenys 89.35 0.00e+00 1095.00
IUUC-Ont-071613 Oreochromis niloticus 72.07 0.00e+00 1270.00
IUUC-Oan-073275 Ornithorhynchus anatinus 89.39 0.00e+00 1635.00
IUUC-Ola-087031 Oryzias latipes 67.51 0.00e+00 1178.00
IUUC-Oga-088201 Otolemur garnettii 86.72 0.00e+00 1506.00
IUUC-Oar-089997 Ovis aries 86.07 0.00e+00 1428.00
IUUC-Ptr-091116 Pan troglodytes 92.37 0.00e+00 1707.00
IUUC-Pan-092132 Papio anubis 92.32 0.00e+00 1129.00
IUUC-Psi-093734 Pelodiscus sinensis 89.21 0.00e+00 1555.00
IUUC-Pma-094347 Petromyzon marinus 72.18 0.00e+00 704.00
IUUC-Pfo-096293 Poecilia formosa 69.35 0.00e+00 1194.00
IUUC-Pab-098491 Pongo abelii 89.38 0.00e+00 1609.00
IUUC-Pca-101004 Procavia capensis 82.48 0.00e+00 922.00
IUUC-Pva-102961 Pteropus vampyrus 71.07 0.00e+00 885.00
IUUC-Rno-105005 Rattus norvegicus 91.16 0.00e+00 1591.00
IUUC-Sha-107646 Sarcophilus harrisii 64.99 0.00e+00 959.00
IUUC-Tgu-116776 Taeniopygia guttata 89.45 0.00e+00 1613.00
IUUC-Tru-118180 Takifugu rubripes 70.27 0.00e+00 1273.00
IUUC-Tsy-119468 Tarsius syrichta 88.41 0.00e+00 762.00
IUUC-Tni-120196 Tetraodon nigroviridis 70.32 0.00e+00 1253.00
IUUC-Ttr-128360 Tursiops truncatus 84.75 0.00e+00 988.00
IUUC-Xtr-132956 Xenopus tropicalis 80.97 0.00e+00 1424.00
Created Date 25-Jun-2017

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