iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053890

Ensembl Protein ID

ENSLAFP00000023929.1

UniProt Accession

G3U7X1; G3U7X1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000026624.1	ENSLAFT00000029348.1	ENSLAFP00000023164.1
ENSLAFG00000026624.1	ENSLAFT00000037447.1	ENSLAFP00000023929.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.50e-38	130.4	120	301
UBD/ZnF/ZnF_A20	7.20e-17	61.4	550	584

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 120  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 208
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 209  lgtN-GancggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPANQcHRSPLVLAYDQAHFS 296
           7650.255579****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 297  ALVSM 301
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 550  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 584
           59********************************9 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

TPEKGFSDRE STRPPRPTLQ RQDDIVQEKR LSRGISHASS SIVSLARSHV SSNGGGGGSN 60
EHPLEMPICA FQLPDLTVYN EDFRSFIERD LIEQSMLVAL EQAGRLNWWA SVDPTCQRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTCC GTTCCACAGG AGCAGAGCCA 60
GGGCTGGCCC GAGATCTCCT GGAAGGTAAG GAGTCTTTAA GGGAGAGTAA AGAGAGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-024729	Choloepus hoffmanni	93.58	3.00e-109	389.00
IUUC-Dor-031121	Dipodomys ordii	82.58	3.00e-138	484.00
IUUC-Opr-070564	Ochotona princeps	94.55	1.00e-164	573.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence