iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090086

Ensembl Protein ID

ENSOARP00000022305.1

UniProt Accession

W5QHV5; W5QHV5_SHEEP

Genbank Protein ID

ENSOARP00000022305

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01004579

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020754.1	ENSOART00000022610.1	ENSOARP00000022305.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	4.40e-37	127.7	184	365
UBD/ZnF/ZnF_A20	1.10e-16	60.7	796	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYALMDKGAEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GagcggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7640.256688****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 796  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 830
           59********************************9 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPPFSEGS 60
GGSRTPEKGF SDRESTRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGTCACA TTAAAAAAGA GTTTGGTGCG GTCTTGCATC TCCTGTCCCC TGAATGCTCT 60
ATCAGTTTCC AGTAGCCTGA ATTTGGCCTG CCTCCCAGTG CTGACCTAGT CAGGGGACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

oas:101116276

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	95.63	0.00e+00	1476.00
IUUC-Apl-003567	Anas platyrhynchos	66.32	0.00e+00	942.00
IUUC-Bta-013398	Bos taurus	98.70	0.00e+00	1474.00
IUUC-Cel-018468	Caenorhabditis elegans	50.16	5.00e-85	308.00
IUUC-Cja-019965	Callithrix jacchus	92.66	0.00e+00	1365.00
IUUC-Cfa-020191	Canis familiaris	95.49	0.00e+00	1442.00
IUUC-Cpo-022232	Cavia porcellus	91.32	0.00e+00	1334.00
IUUC-Csa-023593	Chlorocebus sabaeus	94.31	0.00e+00	1454.00
IUUC-Cho-024729	Choloepus hoffmanni	86.07	8.00e-173	600.00
IUUC-Csv-026177	Ciona savignyi	30.56	4.00e-03	34.70
IUUC-Dno-029900	Dasypus novemcinctus	94.17	0.00e+00	1409.00
IUUC-Dor-031121	Dipodomys ordii	86.31	0.00e+00	695.00
IUUC-Ete-032473	Echinops telfairi	88.64	0.00e+00	1045.00
IUUC-Eca-033946	Equus caballus	97.26	0.00e+00	1070.00
IUUC-Eeu-034670	Erinaceus europaeus	93.59	0.00e+00	1377.00
IUUC-Fca-035871	Felis catus	95.97	0.00e+00	1373.00
IUUC-Fso-038203	Fusarium solani	30.61	1.90e-02	34.70
IUUC-Gmo-039373	Gadus morhua	76.82	0.00e+00	674.00
IUUC-Gga-041105	Gallus gallus	68.39	0.00e+00	976.00
IUUC-Gac-041806	Gasterosteus aculeatus	56.80	0.00e+00	808.00
IUUC-Ggo-045472	Gorilla gorilla	94.54	0.00e+00	1411.00
IUUC-Hsa-046473	Homo sapiens	94.31	0.00e+00	1412.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	95.73	0.00e+00	1437.00
IUUC-Lch-050432	Latimeria chalumnae	64.04	0.00e+00	954.00
IUUC-Mcc-055261	Macaca mulatta	94.07	0.00e+00	1456.00
IUUC-Meu-056477	Macropus eugenii	80.50	0.00e+00	949.00
IUUC-Mga-059533	Meleagris gallopavo	69.88	0.00e+00	977.00
IUUC-Mdo-062847	Monodelphis domestica	83.06	0.00e+00	1145.00
IUUC-Mmu-064260	Mus musculus	89.57	0.00e+00	1318.00
IUUC-Mpu-066876	Mustela putorius furo	91.12	0.00e+00	1365.00
IUUC-Mlu-068039	Myotis lucifugus	95.38	0.00e+00	1439.00
IUUC-Nle-069260	Nomascus leucogenys	93.95	0.00e+00	1409.00
IUUC-Opr-070564	Ochotona princeps	91.38	0.00e+00	787.00
IUUC-Ocu-073824	Oryctolagus cuniculus	95.02	0.00e+00	953.00
IUUC-Opu-083273	Oryza punctata	23.38	5.40e-01	29.30
IUUC-Oga-088124	Otolemur garnettii	94.55	0.00e+00	1417.00
IUUC-Ptr-091622	Pan troglodytes	95.59	0.00e+00	1102.00
IUUC-Pan-092724	Papio anubis	94.19	0.00e+00	1454.00
IUUC-Psi-093333	Pelodiscus sinensis	63.87	0.00e+00	932.00
IUUC-Pab-098667	Pongo abelii	94.07	0.00e+00	1387.00
IUUC-Pca-100701	Procavia capensis	92.56	0.00e+00	731.00
IUUC-Pva-102136	Pteropus vampyrus	93.83	0.00e+00	1412.00
IUUC-Rno-105546	Rattus norvegicus	90.52	0.00e+00	1343.00
IUUC-Sha-106732	Sarcophilus harrisii	82.85	0.00e+00	1063.00
IUUC-Sar-113562	Sorex araneus	82.46	0.00e+00	1162.00
IUUC-Ssc-116191	Sus scrofa	96.32	0.00e+00	1432.00
IUUC-Tgu-116942	Taeniopygia guttata	76.34	0.00e+00	792.00
IUUC-Tsy-119343	Tarsius syrichta	86.66	0.00e+00	1253.00
IUUC-Tbe-127283	Tupaia belangeri	94.55	0.00e+00	770.00
IUUC-Ttr-128692	Tursiops truncatus	93.48	0.00e+00	1333.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence