iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059943

UUCD1 version

UUC-MeG-00562

Ensembl Protein ID

ENSMGAP00000002448.2

UniProt Accession

G1MV24; G1MV24_MELGA

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000002737.2	ENSMGAT00000003127.2	ENSMGAP00000002448.2
ENSMGAG00000002737.2	ENSMGAT00000020222.1	ENSMGAP00000018749.1
ENSMGAG00000002737.2	ENSMGAT00000020426.1	ENSMGAP00000017801.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.80e-26	91.8	1124	1177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1124 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1177
           58********************************.*****99999*******876 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

VRQSPRRIKP VRIIPSTKRT DATIAKQLLQ RAKKGAQKKI EKEAAKLQGR KGRTQLKNIR 60
QFIMPVVSAI SSRIIKTPKR FIEDEDYDPP IKISRLESTP NSRFSATSCG SSEKSSAASQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTGTTG AGGTGGGCTA CATCTGAAGG CCTGCGAGAT TGACAGAAGC CACGAAACTG 60
TGTGCTTTCC TTCCTGGGGC TGTGAGCGTG GCTCTTGTGG GAGCAGGGAG AAGCTGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	5.00e-13	69.30
IUUC-Aml-002274	Ailuropoda melanoleuca	77.30	0.00e+00	4545.00
IUUC-Atr-002455	Amborella trichopoda	48.10	2.00e-39	157.00
IUUC-Apl-003478	Anas platyrhynchos	89.04	0.00e+00	4483.00
IUUC-Aca-005086	Anolis carolinensis	65.75	0.00e+00	3544.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	6.00e-40	159.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	1.00e-37	151.00
IUUC-Ame-011195	Astyanax mexicanus	45.14	0.00e+00	786.00
IUUC-Bta-012974	Bos taurus	77.05	0.00e+00	4506.00
IUUC-Bdi-014882	Brachypodium distachyon	33.17	1.00e-25	110.00
IUUC-Bol-016540	Brassica oleracea	48.05	3.00e-38	153.00
IUUC-Cja-019226	Callithrix jacchus	76.23	0.00e+00	4532.00
IUUC-Cfa-021049	Canis familiaris	77.54	0.00e+00	4564.00
IUUC-Cpo-021459	Cavia porcellus	76.22	0.00e+00	3368.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.78	2.00e-39	158.00
IUUC-Csa-023434	Chlorocebus sabaeus	76.24	0.00e+00	4358.00
IUUC-Cho-024652	Choloepus hoffmanni	72.89	0.00e+00	3061.00
IUUC-Cin-025724	Ciona intestinalis	54.78	2.00e-96	347.00
IUUC-Csv-026268	Ciona savignyi	37.20	4.00e-131	462.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	2.00e-12	67.80
IUUC-Dre-028180	Danio rerio	66.67	0.00e+00	1156.00
IUUC-Dno-029068	Dasypus novemcinctus	74.14	0.00e+00	4248.00
IUUC-Dor-030550	Dipodomys ordii	72.46	0.00e+00	4077.00
IUUC-Dme-032023	Drosophila melanogaster	46.82	2.00e-90	328.00
IUUC-Ete-032834	Echinops telfairi	64.93	0.00e+00	1994.00
IUUC-Eca-033615	Equus caballus	77.36	0.00e+00	4439.00
IUUC-Eeu-035136	Erinaceus europaeus	74.38	0.00e+00	1024.00
IUUC-Fca-036453	Felis catus	66.07	0.00e+00	1755.00
IUUC-Fal-037256	Ficedula albicollis	88.15	0.00e+00	5412.00
IUUC-Gmo-038641	Gadus morhua	68.18	0.00e+00	1096.00
IUUC-Gga-040828	Gallus gallus	93.06	0.00e+00	5584.00
IUUC-Gac-041452	Gasterosteus aculeatus	71.06	0.00e+00	1152.00
IUUC-Gma-043554	Glycine max	49.02	5.00e-39	156.00
IUUC-Ggo-045124	Gorilla gorilla	73.54	0.00e+00	4192.00
IUUC-Hsa-046143	Homo sapiens	76.95	0.00e+00	4424.00
IUUC-Hvu-047762	Hordeum vulgare	28.89	8.00e-19	88.20
IUUC-Itr-049024	Ictidomys tridecemlineatus	73.67	0.00e+00	3830.00
IUUC-Lch-049704	Latimeria chalumnae	65.11	0.00e+00	3695.00
IUUC-Lpe-051476	Leersia perrieri	30.09	8.00e-22	98.60
IUUC-Loc-052181	Lepisosteus oculatus	79.17	0.00e+00	1286.00
IUUC-Laf-053946	Loxodonta africana	77.67	0.00e+00	4395.00
IUUC-Mcc-055508	Macaca mulatta	76.48	0.00e+00	4450.00
IUUC-Meu-056485	Macropus eugenii	71.83	0.00e+00	2085.00
IUUC-Mtr-058327	Medicago truncatula	41.96	1.00e-39	158.00
IUUC-Mmr-061178	Microcebus murinus	74.74	0.00e+00	3430.00
IUUC-Mdo-063031	Monodelphis domestica	77.39	0.00e+00	3493.00
IUUC-Mmu-063650	Mus musculus	74.55	0.00e+00	3311.00
IUUC-Mpu-066495	Mustela putorius furo	78.53	0.00e+00	3283.00
IUUC-Mlu-068045	Myotis lucifugus	72.72	0.00e+00	4197.00
IUUC-Nle-069064	Nomascus leucogenys	77.18	0.00e+00	4493.00
IUUC-Opr-071043	Ochotona princeps	70.90	0.00e+00	2893.00
IUUC-Ont-072556	Oreochromis niloticus	64.38	0.00e+00	1125.00
IUUC-Oan-073324	Ornithorhynchus anatinus	74.65	0.00e+00	2050.00
IUUC-Ocu-074190	Oryctolagus cuniculus	76.28	0.00e+00	4470.00
IUUC-Oba-075647	Oryza barthii	49.36	7.00e-39	155.00
IUUC-Obr-076458	Oryza brachyantha	33.00	2.00e-25	110.00
IUUC-Ogl-077851	Oryza glaberrima	31.74	1.00e-24	107.00
IUUC-Ogu-078706	Oryza glumaepatula	31.84	3.00e-25	110.00
IUUC-Oin-079802	Oryza indica	29.13	1.00e-19	91.30
IUUC-Olo-080577	Oryza longistaminata	47.71	2.00e-36	147.00
IUUC-Ome-081214	Oryza meridionalis	49.36	8.00e-39	155.00
IUUC-Oni-083000	Oryza nivara	49.36	8.00e-39	155.00
IUUC-Opu-083842	Oryza punctata	49.36	8.00e-39	155.00
IUUC-Oru-084361	Oryza rufipogon	49.36	8.00e-39	155.00
IUUC-Osa-085421	Oryza sativa	32.49	2.00e-24	107.00
IUUC-Ola-086609	Oryzias latipes	46.74	0.00e+00	735.00
IUUC-Oga-088208	Otolemur garnettii	76.65	0.00e+00	4439.00
IUUC-Oar-090152	Ovis aries	76.75	0.00e+00	4522.00
IUUC-Ptr-091127	Pan troglodytes	77.01	0.00e+00	4429.00
IUUC-Pan-092679	Papio anubis	75.69	0.00e+00	3771.00
IUUC-Psi-094059	Pelodiscus sinensis	83.58	0.00e+00	5013.00
IUUC-Pma-094258	Petromyzon marinus	59.53	0.00e+00	676.00
IUUC-Pfo-096536	Poecilia formosa	68.83	0.00e+00	1127.00
IUUC-Pab-098262	Pongo abelii	77.38	0.00e+00	4504.00
IUUC-Pca-100358	Procavia capensis	73.34	0.00e+00	4163.00
IUUC-Pva-102522	Pteropus vampyrus	71.29	0.00e+00	3656.00
IUUC-Rno-105200	Rattus norvegicus	74.12	0.00e+00	3254.00
IUUC-Sce-106318	Saccharomyces cerevisiae	25.35	5.40e-02	33.10
IUUC-Sha-107174	Sarcophilus harrisii	78.46	0.00e+00	4586.00
IUUC-Smo-109164	Selaginella moellendorffii	51.30	9.00e-41	162.00
IUUC-Sit-110552	Setaria italica	32.19	3.00e-26	113.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	1.00e-36	148.00
IUUC-Stu-112529	Solanum tuberosum	48.37	7.00e-39	154.00
IUUC-Sar-113503	Sorex araneus	64.85	0.00e+00	1790.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	4.00e-10	59.70
IUUC-Ssc-115509	Sus scrofa	51.17	0.00e+00	753.00
IUUC-Tgu-117047	Taeniopygia guttata	87.94	0.00e+00	5355.00
IUUC-Tru-118328	Takifugu rubripes	66.02	0.00e+00	1140.00
IUUC-Tsy-118953	Tarsius syrichta	67.16	0.00e+00	2145.00
IUUC-Tni-120837	Tetraodon nigroviridis	67.51	0.00e+00	1130.00
IUUC-Tae-125629	Triticum aestivum	29.72	7.00e-19	88.20
IUUC-Tbe-127950	Tupaia belangeri	67.75	0.00e+00	2042.00
IUUC-Ttr-128643	Tursiops truncatus	75.89	0.00e+00	4277.00
IUUC-Vpa-130660	Vicugna pacos	79.29	0.00e+00	1784.00
IUUC-Vvi-131476	Vitis vinifera	46.75	5.00e-40	159.00
IUUC-Xtr-132869	Xenopus tropicalis	59.01	0.00e+00	3392.00
IUUC-Xma-133393	Xiphophorus maculatus	65.43	0.00e+00	1079.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence