iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067261

Ensembl Protein ID

ENSMLUP00000006392.2

UniProt Accession

G1P8A1; G1P8A1_MYOLU

Genbank Protein ID

ENSMLUP00000006392

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAPE02001257

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006970.2	ENSMLUT00000006991.2	ENSMLUP00000006392.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.20e-14	53.4	1712	1752

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1712 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1752
           8*********....*******************....99996.******8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MDQTSELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSTFS EPLNECTMQL STASGTSQNA 60
YGQDSPSCYI PLRKLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP IVCTSLSPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGA CCTCTGAACT ACCCAGAAGA AATTGTCTGC TGCCTTTTTC CAATCCAGTC 60
AATTTAGATG CCCCTGAAGA CAAGGACAGC CCTTTCGGTA ATGGTCAATC CACTTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	29.53	9.00e-12	65.50
IUUC-Aml-001795	Ailuropoda melanoleuca	92.12	0.00e+00	4807.00
IUUC-Apl-003953	Anas platyrhynchos	57.12	0.00e+00	2225.00
IUUC-Aca-005339	Anolis carolinensis	59.64	0.00e+00	1502.00
IUUC-Ame-011932	Astyanax mexicanus	62.61	0.00e+00	922.00
IUUC-Bta-012966	Bos taurus	91.38	0.00e+00	4830.00
IUUC-Bdi-014781	Brachypodium distachyon	29.61	7.00e-13	69.30
IUUC-Bol-016001	Brassica oleracea	28.96	2.00e-16	82.00
IUUC-Bra-017864	Brassica rapa	28.42	3.00e-15	78.20
IUUC-Cja-018780	Callithrix jacchus	88.78	0.00e+00	4361.00
IUUC-Cfa-020975	Canis familiaris	91.42	0.00e+00	4811.00
IUUC-Cpo-021331	Cavia porcellus	86.86	0.00e+00	2644.00
IUUC-Csa-024226	Chlorocebus sabaeus	88.13	0.00e+00	4068.00
IUUC-Cho-024464	Choloepus hoffmanni	75.05	0.00e+00	1380.00
IUUC-Csv-026298	Ciona savignyi	38.54	6.00e-57	214.00
IUUC-Dre-028152	Danio rerio	63.13	0.00e+00	1256.00
IUUC-Dno-029230	Dasypus novemcinctus	87.12	0.00e+00	4495.00
IUUC-Dor-031016	Dipodomys ordii	79.55	0.00e+00	1278.00
IUUC-Dme-032193	Drosophila melanogaster	36.70	1.00e-122	434.00
IUUC-Ete-032488	Echinops telfairi	61.38	0.00e+00	858.00
IUUC-Eca-033591	Equus caballus	90.81	0.00e+00	4242.00
IUUC-Fca-035791	Felis catus	92.05	0.00e+00	4932.00
IUUC-Fal-037378	Ficedula albicollis	58.60	0.00e+00	2056.00
IUUC-Gmo-038919	Gadus morhua	71.20	0.00e+00	937.00
IUUC-Gga-040881	Gallus gallus	56.88	0.00e+00	2159.00
IUUC-Gac-041378	Gasterosteus aculeatus	77.54	0.00e+00	1071.00
IUUC-Hsa-046436	Homo sapiens	89.28	0.00e+00	4645.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	87.59	0.00e+00	4146.00
IUUC-Lch-049684	Latimeria chalumnae	47.89	0.00e+00	1702.00
IUUC-Lpe-051661	Leersia perrieri	28.72	6.00e-12	66.60
IUUC-Loc-052766	Lepisosteus oculatus	66.23	0.00e+00	995.00
IUUC-Laf-054046	Loxodonta africana	88.19	0.00e+00	4054.00
IUUC-Mcc-055593	Macaca mulatta	88.80	0.00e+00	4601.00
IUUC-Meu-056051	Macropus eugenii	66.53	0.00e+00	702.00
IUUC-Mga-059756	Meleagris gallopavo	56.86	0.00e+00	2206.00
IUUC-Mmr-061182	Microcebus murinus	88.17	0.00e+00	4673.00
IUUC-Mdo-061984	Monodelphis domestica	68.70	0.00e+00	3045.00
IUUC-Mmu-063605	Mus musculus	81.86	0.00e+00	4261.00
IUUC-Mpu-066446	Mustela putorius furo	91.49	0.00e+00	4863.00
IUUC-Nle-069818	Nomascus leucogenys	88.50	0.00e+00	4114.00
IUUC-Opr-070842	Ochotona princeps	82.36	0.00e+00	2319.00
IUUC-Ont-072448	Oreochromis niloticus	75.22	0.00e+00	1149.00
IUUC-Oan-073496	Ornithorhynchus anatinus	71.90	0.00e+00	1662.00
IUUC-Ocu-074918	Oryctolagus cuniculus	88.46	0.00e+00	4690.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.50
IUUC-Ogu-078898	Oryza glumaepatula	28.90	1.00e-09	57.00
IUUC-Oin-079557	Oryza indica	28.90	1.00e-09	57.00
IUUC-Olo-080702	Oryza longistaminata	39.91	2.00e-43	171.00
IUUC-Opu-083371	Oryza punctata	41.15	4.00e-45	176.00
IUUC-Osa-085353	Oryza sativa	28.90	1.00e-09	57.40
IUUC-Ola-087518	Oryzias latipes	76.21	0.00e+00	1055.00
IUUC-Oga-088743	Otolemur garnettii	86.75	0.00e+00	3974.00
IUUC-Oar-090265	Ovis aries	90.75	0.00e+00	4798.00
IUUC-Ptr-090521	Pan troglodytes	89.54	0.00e+00	4671.00
IUUC-Psi-093245	Pelodiscus sinensis	59.54	0.00e+00	2047.00
IUUC-Pma-094747	Petromyzon marinus	65.77	0.00e+00	684.00
IUUC-Pfo-096066	Poecilia formosa	61.66	0.00e+00	1225.00
IUUC-Pab-098644	Pongo abelii	88.13	0.00e+00	4075.00
IUUC-Pva-103094	Pteropus vampyrus	90.46	0.00e+00	2767.00
IUUC-Rno-105803	Rattus norvegicus	81.66	0.00e+00	3755.00
IUUC-Sha-107278	Sarcophilus harrisii	69.57	0.00e+00	3477.00
IUUC-Sar-113402	Sorex araneus	76.31	0.00e+00	2617.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	3.00e-13	67.00
IUUC-Ssc-116193	Sus scrofa	90.48	0.00e+00	4131.00
IUUC-Tgu-116532	Taeniopygia guttata	89.70	0.00e+00	1254.00
IUUC-Tru-117988	Takifugu rubripes	77.71	0.00e+00	1203.00
IUUC-Tsy-118830	Tarsius syrichta	87.78	0.00e+00	3691.00
IUUC-Tni-120452	Tetraodon nigroviridis	60.94	0.00e+00	934.00
IUUC-Tca-121456	Theobroma cacao	30.81	6.00e-20	92.80
IUUC-Tae-124687	Triticum aestivum	29.53	1.00e-11	65.50
IUUC-Ttr-128240	Tursiops truncatus	59.78	0.00e+00	919.00
IUUC-Vpa-130666	Vicugna pacos	58.95	0.00e+00	898.00
IUUC-Xtr-132673	Xenopus tropicalis	63.98	0.00e+00	962.00
IUUC-Xma-133606	Xiphophorus maculatus	76.95	0.00e+00	1143.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence