iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092745

Ensembl Protein ID

ENSPANP00000007232.1

UniProt Accession

A0A096N4B9; A0A096N4B9_PAPAN

Genbank Protein ID

ENSPANP00000007232

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01061907

Gene Name

TRIM6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000008345.1	ENSPANT00000008001.1	ENSPANP00000007232.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.60e-08	35.0	15	60
E3 activity/RING/U-box	2.50e-06	27.5	9	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+  +    ++  + +e +CP+C+
   Q: 15   CPICLELLTE-PLSIDCGHSFCQACItpNS-RESMIGQEGERSCPVCQ 60
           ********99.***************8633.478899**********7 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrli 65
           + ee  CpI lel ++P  + +G+++ +++I          ++g+++cPv++++ ++ +l Pn  l +++
   Q: 9    IREEVTCPICLELLTEPLSIDCGHSFCQACITPNSresmigQEGERSCPVCQTSYQPGNLRPNRHLANIV 78
           678999*************************986633334555555*****************9987765 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNSRESMIGQ EGERSCPVCQ 60
TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE HGKVICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTTCAC CAGTACTGGT GGACATACGA GAAGAGGTGA CCTGCCCTAT CTGCCTGGAG 60
CTCCTAACAG AACCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAAGC CTGCATCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	83.20	0.00e+00	805.00
IUUC-Cel-018370	Caenorhabditis elegans	33.75	6.00e-10	58.20
IUUC-Cja-019394	Callithrix jacchus	71.11	7.00e-137	479.00
IUUC-Dno-029492	Dasypus novemcinctus	55.17	4.00e-145	508.00
IUUC-Dor-030480	Dipodomys ordii	79.33	2.00e-132	466.00
IUUC-Fca-035533	Felis catus	82.58	0.00e+00	801.00
IUUC-Hsa-046006	Homo sapiens	97.13	0.00e+00	957.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	79.74	0.00e+00	764.00
IUUC-Laf-053805	Loxodonta africana	79.92	0.00e+00	736.00
IUUC-Mmr-061023	Microcebus murinus	83.92	0.00e+00	796.00
IUUC-Mmu-063682	Mus musculus	80.33	0.00e+00	800.00
IUUC-Mpu-065842	Mustela putorius furo	81.72	0.00e+00	791.00
IUUC-Oga-088267	Otolemur garnettii	85.86	0.00e+00	823.00
IUUC-Ptr-090573	Pan troglodytes	97.34	0.00e+00	959.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence