iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003512

Ensembl Protein ID

ENSAPLP00000006904.1

UniProt Accession

U3II32; U3II32_ANAPL

Genbank Protein ID

ENSAPLP00000006904

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01084637

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007229.1	ENSAPLT00000007555.1	ENSAPLP00000006904.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.30e-84	281.7	192	813

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenp..............kepkgellkslqklfeelwkskkkavsp 70
           +G++NlgNtC++N+v+Q L++++ l el+ e           +  +                ++ g+l++++  +++++ +  ++  sp
   Q: 192  KGINNLGNTCFFNAVMQNLAQTHILNELMYEmkekgT-----KL-KIchtsdsqldplvvnLSSPGPLTSAMFLFLHSMREAGRGPLSP 274
           59*****************************443331.....32.223445556666777777888*********************** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksq 153
           + l+++l+++a++f+g++qqD+qE+l++lld+++ e +k+ ++ + +++++ ++++ de      + +  +  + ++i+++F g+l+s+
   Q: 275  KVLFSQLCQKAPRFKGFQQQDSQELLHYLLDAMRIEETKRIQTGILKAFNNPTTKTADEetrrkvKAYGREGVKMNFIDRIFVGELTST 363
           ***********************************9999788888888777777777773333335555555555************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           ++c+ec+n+s+ +epf+dlslp+ +++  k+                                                          
   Q: 364  VMCEECENISTVKEPFIDLSLPIIEERVAKPVplgrtskgksvqeadlgqcncssistlnnqpkivkkhtltkdknqlnqerrlarkas 452
           ***************************98777********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  sneeerspiimeeknktrelegssgmlypkdptaesavngsqtegsekeasrsessfdadseasesesaskqsafssssnlsalhvnhi 541
           ***************************************************************************************** PP
   S: 186  ..............................................................................slqdcLesftk 196
                                                                                         s+q+cL +ft+
   Q: 542  nmkmphtkpsdnsdevissaisklsfcdtinedekssrgdsglsnnsmfsvdksslsqnpqnafqtlsqtyitsskecSVQSCLYQFTS 630
           ***************************************************************************************** PP
   S: 197  eeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
            e l g+nk+ ce+c+++++                   a+k+l ++++P +LilhLkRf  ++++ s +k+n++v+fpl Ldl+pfc+
   Q: 631  VELLMGNNKLLCESCTERKQkyqkktnsterkmegvytnARKQLLISSVPAILILHLKRF--HQAGLSLRKVNRHVDFPLILDLAPFCS 717
           ****************88888889999999999999999*********************..9999*********************** PP
   S: 267  speekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetg 327
            +++++++  ++ Y+L+++v HsGs+++GHY ayvk                           ++g+W++++D +V+ v+e++vl+   
   Q: 718  ASCKNVTDsaRVLYSLYGIVEHSGSMRGGHYAAYVKVrtpskkllehistsknvlglkeavgtSSGQWVYVSDAHVQMVPESRVLN--- 803
           *99887666699*************************999999999999999999999999888999*******************... PP
   S: 328  staYvlfYkr 337
           ++aY+lfY+r
   Q: 804  AQAYLLFYER 813
           ********98 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MRVKDPSRAN PEKTKRSKRP NRPQDEDSSD DIAVGLTCQH VSQAVDVHHV KRAVAQSIWS 60
VCSECLKERR MSDGEPVAPS DIWLCLKCGS QGCSKNSEGQ HSLKHFQTVR TEPHCIVISL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGTGTGA AAGATCCATC AAGAGCCAAC CCTGAGAAAA CAAAGAGAAG CAAAAGGCCT 60
AACAGGCCAC AGGATGAAGA CTCTTCAGAT GATATTGCAG GTAAATACAT TTAAGGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	61.52	0.00e+00	876.00
IUUC-Aca-004284	Anolis carolinensis	71.41	0.00e+00	1139.00
IUUC-Aly-006422	Arabidopsis lyrata	28.46	9.00e-30	125.00
IUUC-Ath-006732	Arabidopsis thaliana	29.97	1.00e-34	141.00
IUUC-Ame-010735	Astyanax mexicanus	60.38	1.00e-87	316.00
IUUC-Bta-012880	Bos taurus	68.98	0.00e+00	1047.00
IUUC-Cja-019144	Callithrix jacchus	68.04	0.00e+00	1084.00
IUUC-Cfa-020971	Canis familiaris	70.75	0.00e+00	635.00
IUUC-Cpo-022497	Cavia porcellus	72.89	0.00e+00	638.00
IUUC-Csa-023910	Chlorocebus sabaeus	66.75	0.00e+00	981.00
IUUC-Cho-024358	Choloepus hoffmanni	51.43	1.00e-90	326.00
IUUC-Cme-027348	Cyanidioschyzon merolae	36.02	2.00e-20	93.60
IUUC-Dre-028106	Danio rerio	56.83	4.00e-165	574.00
IUUC-Dno-029456	Dasypus novemcinctus	61.00	1.00e-160	559.00
IUUC-Dor-030438	Dipodomys ordii	53.16	0.00e+00	742.00
IUUC-Dme-031870	Drosophila melanogaster	51.30	3.00e-38	153.00
IUUC-Ete-032736	Echinops telfairi	55.56	0.00e+00	790.00
IUUC-Eca-034211	Equus caballus	67.80	0.00e+00	1075.00
IUUC-Eeu-034797	Erinaceus europaeus	76.88	3.00e-79	288.00
IUUC-Fca-035947	Felis catus	65.49	0.00e+00	940.00
IUUC-Fal-037199	Ficedula albicollis	91.15	0.00e+00	1302.00
IUUC-Gmo-039228	Gadus morhua	65.82	2.00e-152	532.00
IUUC-Gga-040823	Gallus gallus	90.64	0.00e+00	860.00
IUUC-Gac-042406	Gasterosteus aculeatus	64.00	6.00e-150	524.00
IUUC-Ggo-045402	Gorilla gorilla	66.99	0.00e+00	1049.00
IUUC-Hsa-046430	Homo sapiens	66.95	0.00e+00	1050.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	65.29	7.00e-165	573.00
IUUC-Lch-049547	Latimeria chalumnae	64.86	0.00e+00	1004.00
IUUC-Loc-052842	Lepisosteus oculatus	60.68	0.00e+00	988.00
IUUC-Laf-053988	Loxodonta africana	68.20	0.00e+00	1074.00
IUUC-Mcc-055491	Macaca mulatta	64.68	0.00e+00	1003.00
IUUC-Meu-056256	Macropus eugenii	67.96	0.00e+00	652.00
IUUC-Mla-059026	Melampsora laricipopulina	31.71	9.00e-19	88.20
IUUC-Mga-059833	Meleagris gallopavo	86.06	0.00e+00	880.00
IUUC-Mmr-060952	Microcebus murinus	67.23	0.00e+00	1045.00
IUUC-Mdo-062642	Monodelphis domestica	74.30	0.00e+00	1157.00
IUUC-Mmu-063945	Mus musculus	63.47	0.00e+00	1018.00
IUUC-Mpu-065944	Mustela putorius furo	65.88	0.00e+00	659.00
IUUC-Mlu-067049	Myotis lucifugus	66.10	0.00e+00	999.00
IUUC-Nle-069828	Nomascus leucogenys	67.60	0.00e+00	1062.00
IUUC-Opr-070672	Ochotona princeps	62.37	4.00e-123	435.00
IUUC-Ont-072121	Oreochromis niloticus	65.52	1.00e-151	530.00
IUUC-Oan-073656	Ornithorhynchus anatinus	77.63	0.00e+00	806.00
IUUC-Ocu-074323	Oryctolagus cuniculus	65.98	0.00e+00	1020.00
IUUC-Ola-087238	Oryzias latipes	56.85	0.00e+00	861.00
IUUC-Oga-088379	Otolemur garnettii	65.10	0.00e+00	1005.00
IUUC-Oar-089718	Ovis aries	68.69	0.00e+00	1045.00
IUUC-Ptr-091358	Pan troglodytes	66.95	0.00e+00	1051.00
IUUC-Pan-092023	Papio anubis	67.11	0.00e+00	1046.00
IUUC-Psi-093256	Pelodiscus sinensis	82.08	0.00e+00	1236.00
IUUC-Ppa-095584	Physcomitrella patens	30.27	1.00e-37	151.00
IUUC-Pfo-097285	Poecilia formosa	57.35	2.00e-129	456.00
IUUC-Pab-098539	Pongo abelii	67.31	0.00e+00	1063.00
IUUC-Pca-100610	Procavia capensis	58.58	1.00e-134	473.00
IUUC-Pva-102985	Pteropus vampyrus	76.61	2.00e-173	602.00
IUUC-Rno-105538	Rattus norvegicus	64.32	0.00e+00	1026.00
IUUC-Sha-107022	Sarcophilus harrisii	78.05	0.00e+00	703.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.85	8.00e-22	98.60
IUUC-Spo-108149	Schizosaccharomyces pombe	31.86	4.00e-23	103.00
IUUC-Sar-113637	Sorex araneus	64.44	0.00e+00	643.00
IUUC-Ssc-115870	Sus scrofa	68.49	0.00e+00	1080.00
IUUC-Tgu-116907	Taeniopygia guttata	90.45	0.00e+00	1467.00
IUUC-Tru-117835	Takifugu rubripes	54.18	2.00e-115	410.00
IUUC-Tsy-118869	Tarsius syrichta	61.94	0.00e+00	928.00
IUUC-Tni-119716	Tetraodon nigroviridis	68.24	5.00e-103	368.00
IUUC-Tbe-128041	Tupaia belangeri	53.45	0.00e+00	722.00
IUUC-Ttr-128901	Tursiops truncatus	65.21	0.00e+00	1007.00
IUUC-Vpa-130331	Vicugna pacos	67.87	0.00e+00	970.00
IUUC-Xtr-131794	Xenopus tropicalis	56.87	0.00e+00	852.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence