iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087238

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

BAAF04030089

Gene Name

usp45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000002170.1	ENSORLT00000002701.1	ENSORLP00000002700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.40e-87	292.2	193	802

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprel 73
           +G++NlgNtC++N+v+Q Ls+++ l +l+ e  +k +k++                    + ++l+ ++  +++++ +  k+ ++p+ l
   Q: 193  KGITNLGNTCFFNAVMQNLSQTHMLIDLIQEvkEKGHKMK---IcppvemnlnpltvtLPSPEPLTAAMFVFLQSMKEAGKGPINPKIL 278
           59*****************************542333333...23446666666666666666************************** PP
   S: 74   lkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikc 156
           +++l+++a++f+gy+qqD+qE+l++lld+++ e +k+ +  + +++++ ++++ de      + + k+  + ++++++F g+l+++i+c
   Q: 279  FNQLCQKAPRFKGYQQQDSQELLHYLLDSIRVEETKRVKAAILKAFNNPTEKTADEetkrqvKAYGKEGVKLNFVDRIFVGELTNTIMC 367
           *******************************99999777777777777666666663333335566666666***************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke............................................................ 185
           +ec+++s+ +e f+d+slp+ +++ +k++                                                            
   Q: 368  EECEHISTVKEAFIDISLPIIEERMSKPSnpgrigkasreqdvhtahhdlsvahpvnkntkkqsgqkspfrllfeqkqlrrksssslee 456
           ************************98888************************************************************ PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 457  kgascgaeqpeedgvaggsarwlpvckmaaagslsdgserdsgaqdssndadseasesewaprasshalghtstspqasssspspsllt 545
           ***************************************************************************************** PP
   S: 186  ................................................................slqdcLesftkeeelegenkyycek 210
                                                                           s+q+cL++ft+ e l g+nk+ ce+
   Q: 546  rqcgaveqiaaavskvslgfnsgdgsasahccheeqtqnrdnlqhhqgafqalshsytpsskecSIQSCLHQFTSVELLMGNNKLLCES 634
           ***************************************************************************************** PP
   S: 211  ckkkqe.....................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kk 276
           c+++++                     a+k++ ++ lP+v++lhLkRf  ++++++ +k+n++v+fpl Ldl+pfc+ ++++ +   ++
   Q: 635  CTERRQkqtssvfcafaekkvekiytsARKQMLISLLPPVIMLHLKRF--HQAGMNLRKVNRHVDFPLILDLAPFCSASCKNLAAgeRV 721
           **9999999999999999999***************************..9999************************99888766699 PP
   S: 277  kYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y+L+++v HsGs+++GHY ayvk                        ++g+W++++D++V++v+e++vl+   s+aY+lfY++
   Q: 722  LYSLYGIVEHSGSMRGGHYAAYVKVrppqrrtellhknlsgardascsSQGQWVYVSDTTVQTVPESRVLN---SQAYLLFYEE 802
           *************************999999999999999999999888999*******************...********97 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MRLKDPFSSK AVEMTKRTNK PRKPRDEESS DEVSGLTCQH VNKAVDLGSV KKSVLSGMWL 60
VCSDCLKERT MIDGEPVASH DILVCLKCGF QGCNQSEIQH AVKHHQAFHL ESHCITISLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGTCACG TTAAACTATG CTTTTGGCTA TTGCTACCAA CAGCTTACCG ACTTTTATTT 60
TTAACTAAAT TAAATAATAA AGAACAGCAA AGAAACTGCT ACAATTACAG TCGTTTAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	58.31	3.00e-124	439.00
IUUC-Atr-003015	Amborella trichopoda	29.90	3.00e-33	137.00
IUUC-Apl-003512	Anas platyrhynchos	56.85	0.00e+00	862.00
IUUC-Aca-004284	Anolis carolinensis	55.73	0.00e+00	827.00
IUUC-Ame-010735	Astyanax mexicanus	59.92	8.00e-142	496.00
IUUC-Bta-012880	Bos taurus	52.27	0.00e+00	759.00
IUUC-Bol-015941	Brassica oleracea	30.69	2.00e-30	128.00
IUUC-Bra-016751	Brassica rapa	30.15	8.00e-29	122.00
IUUC-Cja-019144	Callithrix jacchus	53.67	0.00e+00	795.00
IUUC-Cfa-020971	Canis familiaris	59.61	2.00e-144	506.00
IUUC-Cpo-022497	Cavia porcellus	56.39	6.00e-143	501.00
IUUC-Csa-023910	Chlorocebus sabaeus	59.08	6.00e-146	511.00
IUUC-Cho-024358	Choloepus hoffmanni	42.12	3.00e-70	258.00
IUUC-Csv-026075	Ciona savignyi	44.50	2.00e-44	173.00
IUUC-Cme-027348	Cyanidioschyzon merolae	36.24	8.00e-16	79.00
IUUC-Dre-028106	Danio rerio	70.72	0.00e+00	1124.00
IUUC-Dno-029456	Dasypus novemcinctus	49.14	5.00e-113	401.00
IUUC-Dor-030438	Dipodomys ordii	46.65	8.00e-102	364.00
IUUC-Dme-031870	Drosophila melanogaster	49.66	1.00e-34	142.00
IUUC-Ete-032736	Echinops telfairi	45.08	6.00e-174	604.00
IUUC-Eca-034211	Equus caballus	52.08	0.00e+00	797.00
IUUC-Eeu-034797	Erinaceus europaeus	60.51	6.00e-69	254.00
IUUC-Fca-035947	Felis catus	53.73	0.00e+00	745.00
IUUC-Fal-037199	Ficedula albicollis	53.68	0.00e+00	732.00
IUUC-Gmo-039228	Gadus morhua	84.26	0.00e+00	689.00
IUUC-Gga-040823	Gallus gallus	53.14	4.00e-130	457.00
IUUC-Gac-042406	Gasterosteus aculeatus	77.83	0.00e+00	1155.00
IUUC-Ggo-045402	Gorilla gorilla	51.13	0.00e+00	783.00
IUUC-Hsa-046430	Homo sapiens	59.66	3.00e-146	512.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	49.90	8.00e-117	413.00
IUUC-Lch-049547	Latimeria chalumnae	52.72	0.00e+00	813.00
IUUC-Loc-052842	Lepisosteus oculatus	63.41	0.00e+00	1011.00
IUUC-Laf-053988	Loxodonta africana	53.66	1.00e-149	523.00
IUUC-Mcc-055491	Macaca mulatta	60.15	1.00e-143	503.00
IUUC-Meu-056256	Macropus eugenii	50.00	8.00e-127	447.00
IUUC-Mla-059026	Melampsora laricipopulina	31.84	1.00e-18	88.20
IUUC-Mga-059833	Meleagris gallopavo	50.46	7.00e-130	457.00
IUUC-Mmr-060952	Microcebus murinus	55.39	1.00e-147	516.00
IUUC-Mdo-062642	Monodelphis domestica	53.88	0.00e+00	800.00
IUUC-Mmu-063945	Mus musculus	52.41	0.00e+00	795.00
IUUC-Mpu-065944	Mustela putorius furo	50.23	0.00e+00	772.00
IUUC-Mlu-067049	Myotis lucifugus	51.36	0.00e+00	766.00
IUUC-Nle-069828	Nomascus leucogenys	51.25	0.00e+00	791.00
IUUC-Opr-070672	Ochotona princeps	45.72	6.00e-87	315.00
IUUC-Ont-072121	Oreochromis niloticus	78.14	0.00e+00	1182.00
IUUC-Oan-073656	Ornithorhynchus anatinus	54.74	0.00e+00	837.00
IUUC-Ocu-074323	Oryctolagus cuniculus	60.44	2.00e-143	503.00
IUUC-Oga-088379	Otolemur garnettii	52.46	4.00e-136	478.00
IUUC-Oar-089718	Ovis aries	51.73	0.00e+00	754.00
IUUC-Ptr-091358	Pan troglodytes	59.42	3.00e-146	512.00
IUUC-Pan-092023	Papio anubis	59.42	3.00e-147	515.00
IUUC-Psi-093256	Pelodiscus sinensis	59.52	2.00e-154	539.00
IUUC-Ppa-095584	Physcomitrella patens	30.12	3.00e-36	147.00
IUUC-Pfo-097285	Poecilia formosa	75.43	0.00e+00	1100.00
IUUC-Pab-098539	Pongo abelii	51.35	0.00e+00	800.00
IUUC-Pca-100610	Procavia capensis	50.27	3.00e-105	375.00
IUUC-Pva-102985	Pteropus vampyrus	59.52	5.00e-134	471.00
IUUC-Rno-105538	Rattus norvegicus	65.02	2.00e-81	296.00
IUUC-Sha-107022	Sarcophilus harrisii	57.43	1.00e-139	489.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	30.43	3.00e-18	87.00
IUUC-Spo-108149	Schizosaccharomyces pombe	31.13	7.00e-21	95.90
IUUC-Sly-111491	Solanum lycopersicum	28.36	4.00e-32	133.00
IUUC-Sar-113637	Sorex araneus	55.04	5.00e-147	514.00
IUUC-Ssc-115870	Sus scrofa	53.33	0.00e+00	812.00
IUUC-Tgu-116907	Taeniopygia guttata	56.97	0.00e+00	862.00
IUUC-Tru-117835	Takifugu rubripes	67.71	0.00e+00	968.00
IUUC-Tsy-118869	Tarsius syrichta	50.94	0.00e+00	693.00
IUUC-Tni-119716	Tetraodon nigroviridis	74.02	0.00e+00	897.00
IUUC-Tbe-128041	Tupaia belangeri	64.19	4.00e-89	322.00
IUUC-Ttr-128901	Tursiops truncatus	51.09	5.00e-132	464.00
IUUC-Vpa-130331	Vicugna pacos	49.74	0.00e+00	713.00
IUUC-Xtr-131794	Xenopus tropicalis	58.87	1.00e-127	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence