iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091706

Ensembl Protein ID

ENSPANP00000003662.1

UniProt Accession

A0A096MUZ3; A0A096MUZ3_PAPAN

Genbank Protein ID

ENSPANP00000003662

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01065680

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000014742.1	ENSPANT00000007551.1	ENSPANP00000003662.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-89	299.8	700	1021

Active Site

Position(s)	Description	Evidence
991	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+k+l+v+f+gE g dl Gv+ref+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G l+g++l++ ++ 
   Q: 700  NEDLRKELWVSFSGEIGYDLVGVKREFFYCLFEEMIQPEYGMFMYPEGASCMWFPVRLKI----EKKRYF-FFGLLCGLSLFNCNVA 781
           689******************************************************998....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           +lp++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+
   Q: 782  NLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSIIVNQTNKRDYVS 863
           *************************************87544444.....455555667779999********************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++++y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G +++d+++++k+++y+ gy++++p+i +Fw+++++++ ee+k
   Q: 864  KYIDYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGHTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKK 950
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++rl  + ++++k   f+++++ ++++  ++ TCf++L LP+Ys++e+++e L++Ai++++gF+
   Q: 951  KFLVFLTGTDRLQTKDLKNMK-ITFCCPESWNERDPMRALTCFSVLFLPKYSTMETVEEALQVAINNNRGFG 1021
           *********************.7799999999**************************************96 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MERRSRRKSR RGGRSTAGQT AASQPAKSPD AQLWLFPSAA GFYRALLRRA EVTRQICCSP 60
RRLAVLERGG AGVQVHQVLA GSGGARTPKC IKLGKNMKIH SVDQGADHML ILSSDGKPFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGTCGCGGAG GAAGTCGCGG CGCGGCGGGC GCTCGACCGC GGGCCAGACC 60
GCCGCGTCTC AGCCTGCGAA GTCTCCGGAC GCGCAGCTCT GGCTCTTCCC CAGCGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	75.75	0.00e+00	1561.00
IUUC-Bta-012422	Bos taurus	74.27	0.00e+00	851.00
IUUC-Cja-018751	Callithrix jacchus	89.81	0.00e+00	1858.00
IUUC-Cfa-020247	Canis familiaris	75.85	0.00e+00	1493.00
IUUC-Csa-023204	Chlorocebus sabaeus	98.17	0.00e+00	1782.00
IUUC-Cho-025101	Choloepus hoffmanni	62.17	5.00e-175	608.00
IUUC-Dno-029795	Dasypus novemcinctus	69.19	0.00e+00	1115.00
IUUC-Dor-030862	Dipodomys ordii	65.09	0.00e+00	1261.00
IUUC-Ete-032585	Echinops telfairi	60.39	0.00e+00	828.00
IUUC-Eca-034358	Equus caballus	75.31	0.00e+00	1463.00
IUUC-Eeu-035282	Erinaceus europaeus	64.73	0.00e+00	721.00
IUUC-Fca-036505	Felis catus	77.04	0.00e+00	1564.00
IUUC-Ggo-045445	Gorilla gorilla	90.80	0.00e+00	1762.00
IUUC-Hsa-046342	Homo sapiens	93.87	0.00e+00	1872.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	70.30	0.00e+00	1410.00
IUUC-Laf-053921	Loxodonta africana	72.29	0.00e+00	1453.00
IUUC-Mcc-054850	Macaca mulatta	98.49	0.00e+00	1791.00
IUUC-Mmr-060783	Microcebus murinus	66.63	0.00e+00	1194.00
IUUC-Mpu-066123	Mustela putorius furo	75.13	0.00e+00	1541.00
IUUC-Mlu-067914	Myotis lucifugus	75.67	0.00e+00	1405.00
IUUC-Nle-069986	Nomascus leucogenys	94.77	0.00e+00	1891.00
IUUC-Opr-070513	Ochotona princeps	67.94	0.00e+00	1017.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.13	0.00e+00	1369.00
IUUC-Oga-088858	Otolemur garnettii	65.87	0.00e+00	1208.00
IUUC-Oar-089456	Ovis aries	76.00	0.00e+00	1490.00
IUUC-Ptr-091216	Pan troglodytes	85.59	0.00e+00	1676.00
IUUC-Pab-097883	Pongo abelii	94.29	0.00e+00	763.00
IUUC-Pca-100320	Procavia capensis	65.13	0.00e+00	1321.00
IUUC-Pva-102646	Pteropus vampyrus	76.90	0.00e+00	1553.00
IUUC-Sar-113605	Sorex araneus	75.54	5.00e-147	514.00
IUUC-Tsy-119240	Tarsius syrichta	66.42	0.00e+00	1234.00
IUUC-Tbe-127787	Tupaia belangeri	70.37	0.00e+00	1325.00
IUUC-Ttr-128191	Tursiops truncatus	73.59	0.00e+00	1463.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence