iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025627

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

EAAA01001942

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000007623.3	ENSCINT00000025142.2	ENSCINP00000024896.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-115	386.5	3962	4295
UBD/Alpha-Helix/UBA	4.80e-07	29.5	1318	1354

Active Site

Position(s)	Description	Evidence
4263	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++l++rl+v f gE+g+d+gGv re++  +s+e++np++ lf++s++d+ t+++np s++ np+hl++F+f+Gr+++ka++d++ll+
   Q: 3962 AELRSRLYVVFDGEDGQDAGGVLREWYLVISREIFNPMYALFRTSPGDHGTYTINPLSYI-NPNHLSYFKFVGRIVAKAIYDNKLLE 4047
           6899*******************************************************9.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           + +++sfyk++lgk++++ d+e+ d e+ + l +++e+   di+ lg +l fsv+ e++g+t++++Lk++G+n pV ++Nk+eY +l
   Q: 4048 CYFTRSFYKHILGKPVKYTDMEADDYEFSQGLRYLLEH---DITSLGTELFFSVEIEEFGKTEVRDLKENGRNLPVSEKNKREYAHL 4131
           ************************************99...********************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           v++ +++  ik+q++af eGf+e+ip++l+s+F+e+elelli+G +++d++dl+++t+y++ y+++sp+iqwFw++l++f++ er++
   Q: 4132 VCQEKMTGAIKKQLAAFLEGFYEIIPKRLISIFDEQELELLISGLPNVDIDDLRQNTEYHK-YQPNSPQIQWFWRALRSFDQAERAK 4217
           ***********************************************************66.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           fLqFvTg+s++Pl+Gf +l+     ++f+i++ d+s++rlP ++TCfn+L+LP Y+++++l+e+Ll+Ai+e+ +gF+l
   Q: 4218 FLQFVTGTSKVPLQGFSTLEgmtgVQKFQIHRdDRSTARLPCAHTCFNQLDLPAYENYDKLRERLLLAITECtEGFGL 4295
           ********************99998899999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +  l+qlv+MGF re++lqaL  a  +leaA+e+Ll++
   Q: 1318 QKDLQQLVDMGFAREQVLQALMHA-STLEAATEWLLTH 1354
           6679*******************7.***********98 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MKIDRNKLKK CTTEVPADCR VLIDKLKTCS DEELVTILES TTAWTVGKCE LYHWVDVLDR 60
FDGILSAAAY TGESEWLLTV NTDEHLQELA LAVLHFTSLL IEYSFSRHLY NSVEHLISLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAATTG ACCGAAACAA ACTCAAAAAA TGCACTACAG AAGTGGTAAG TGCTATGAAT 60
GTTAATCGTA GTATTGTTTT TTTTGCGTTT ATTGCTACAT ATATCCATTG CTTTTTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	45.81	2.00e-103	371.00
IUUC-Aml-001684	Ailuropoda melanoleuca	43.73	0.00e+00	1683.00
IUUC-Atr-002582	Amborella trichopoda	50.12	5.00e-122	432.00
IUUC-Apl-003729	Anas platyrhynchos	74.50	8.00e-163	564.00
IUUC-Aca-005263	Anolis carolinensis	42.13	0.00e+00	1630.00
IUUC-Aly-006157	Arabidopsis lyrata	50.12	3.00e-123	436.00
IUUC-Ath-007472	Arabidopsis thaliana	42.63	6.00e-119	422.00
IUUC-Ago-008005	Ashbya gossypii	51.90	2.00e-127	450.00
IUUC-Acl-008254	Aspergillus clavatus	52.48	2.00e-131	464.00
IUUC-Afl-008712	Aspergillus flavus	52.25	9.00e-132	463.00
IUUC-Afu-009022	Aspergillus fumigatus	52.25	2.00e-131	464.00
IUUC-Ani-009412	Aspergillus nidulans	52.25	1.00e-132	468.00
IUUC-Ang-009771	Aspergillus niger	52.07	2.00e-133	470.00
IUUC-Aor-010186	Aspergillus oryzae	52.04	9.00e-121	427.00
IUUC-Ate-010253	Aspergillus terreus	46.01	2.00e-133	471.00
IUUC-Ame-011067	Astyanax mexicanus	40.65	0.00e+00	1550.00
IUUC-Bgr-012043	Blumeria graminis	44.40	3.00e-130	460.00
IUUC-Bta-012813	Bos taurus	43.50	0.00e+00	1689.00
IUUC-Bci-013995	Botrytis cinerea	51.90	5.00e-133	469.00
IUUC-Bdi-014884	Brachypodium distachyon	50.12	7.00e-123	435.00
IUUC-Bol-016533	Brassica oleracea	55.80	3.00e-89	319.00
IUUC-Bra-016726	Brassica rapa	50.35	5.00e-123	436.00
IUUC-Cel-018179	Caenorhabditis elegans	58.06	5.00e-175	608.00
IUUC-Cja-018741	Callithrix jacchus	43.79	0.00e+00	1690.00
IUUC-Cfa-020083	Canis familiaris	42.93	0.00e+00	1661.00
IUUC-Cpo-021923	Cavia porcellus	43.69	0.00e+00	1681.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.59	1.00e-120	425.00
IUUC-Csa-023853	Chlorocebus sabaeus	43.77	0.00e+00	1689.00
IUUC-Cho-024718	Choloepus hoffmanni	77.39	0.00e+00	656.00
IUUC-Csv-025824	Ciona savignyi	81.71	0.00e+00	2513.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	51.18	6.00e-130	459.00
IUUC-Cne-027095	Cryptococcus neoformans	41.46	7.00e-109	389.00
IUUC-Cme-027267	Cyanidioschyzon merolae	48.62	2.00e-115	409.00
IUUC-Dre-028525	Danio rerio	44.39	0.00e+00	1449.00
IUUC-Dno-029680	Dasypus novemcinctus	44.68	0.00e+00	1646.00
IUUC-Dor-030902	Dipodomys ordii	70.14	0.00e+00	652.00
IUUC-Dse-031197	Dothistroma septosporum	44.19	2.00e-131	463.00
IUUC-Dme-032122	Drosophila melanogaster	71.69	0.00e+00	679.00
IUUC-Ete-032690	Echinops telfairi	66.03	4.00e-143	503.00
IUUC-Eca-033915	Equus caballus	43.43	0.00e+00	1666.00
IUUC-Eeu-034963	Erinaceus europaeus	49.74	0.00e+00	1281.00
IUUC-Fca-035824	Felis catus	43.49	0.00e+00	1685.00
IUUC-Fox-037756	Fusarium oxysporum	52.24	8.00e-132	465.00
IUUC-Fso-038464	Fusarium solani	51.89	2.00e-131	464.00
IUUC-Gmo-039073	Gadus morhua	48.17	0.00e+00	1405.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.59	3.00e-134	473.00
IUUC-Gga-040309	Gallus gallus	80.52	3.00e-156	542.00
IUUC-Gac-042430	Gasterosteus aculeatus	42.46	0.00e+00	1639.00
IUUC-Gma-042956	Glycine max	48.53	5.00e-121	429.00
IUUC-Ggo-044785	Gorilla gorilla	45.25	0.00e+00	1681.00
IUUC-Hsa-046879	Homo sapiens	45.25	0.00e+00	1681.00
IUUC-Hvu-047697	Hordeum vulgare	50.12	4.00e-123	436.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	72.43	0.00e+00	808.00
IUUC-Kpa-049228	Komagataella pastoris	52.80	2.00e-130	461.00
IUUC-Lch-050252	Latimeria chalumnae	47.41	0.00e+00	950.00
IUUC-Lpe-051550	Leersia perrieri	49.65	3.00e-122	433.00
IUUC-Loc-052472	Lepisosteus oculatus	45.41	0.00e+00	1480.00
IUUC-Lma-053159	Leptosphaeria maculans	51.76	7.00e-134	472.00
IUUC-Laf-054154	Loxodonta africana	43.39	0.00e+00	1647.00
IUUC-Mcc-055085	Macaca mulatta	42.99	0.00e+00	1647.00
IUUC-Meu-056727	Macropus eugenii	52.68	0.00e+00	1011.00
IUUC-Mor-057201	Magnaporthe oryzae	53.30	2.00e-135	477.00
IUUC-Mpo-057597	Magnaporthe poae	52.12	4.00e-133	469.00
IUUC-Mtr-058273	Medicago truncatula	50.23	6.00e-124	439.00
IUUC-Mla-058888	Melampsora laricipopulina	49.00	3.00e-114	403.00
IUUC-Mvi-060320	Microbotryum violaceum	49.06	3.00e-120	427.00
IUUC-Mmr-060820	Microcebus murinus	42.89	0.00e+00	1656.00
IUUC-Mdo-062930	Monodelphis domestica	43.08	0.00e+00	1672.00
IUUC-Mmu-063601	Mus musculus	44.68	0.00e+00	1650.00
IUUC-Mac-065229	Musa acuminata	49.19	1.00e-120	428.00
IUUC-Mpu-066653	Mustela putorius furo	42.48	0.00e+00	1578.00
IUUC-Mlu-067418	Myotis lucifugus	43.67	0.00e+00	1709.00
IUUC-Nfi-068278	Neosartorya fischeri	52.48	5.00e-132	466.00
IUUC-Ncr-068813	Neurospora crassa	53.74	2.00e-136	480.00
IUUC-Nle-069418	Nomascus leucogenys	45.34	0.00e+00	1669.00
IUUC-Opr-070187	Ochotona princeps	60.46	8.00e-179	621.00
IUUC-Ont-071300	Oreochromis niloticus	45.83	0.00e+00	1492.00
IUUC-Oan-073046	Ornithorhynchus anatinus	40.17	0.00e+00	1650.00
IUUC-Ocu-074178	Oryctolagus cuniculus	44.02	0.00e+00	1701.00
IUUC-Oba-075757	Oryza barthii	49.65	3.00e-122	433.00
IUUC-Obr-076553	Oryza brachyantha	49.88	3.00e-122	433.00
IUUC-Ogl-077520	Oryza glaberrima	49.65	3.00e-122	433.00
IUUC-Ogu-078278	Oryza glumaepatula	49.65	3.00e-122	433.00
IUUC-Oin-079767	Oryza indica	49.65	3.00e-122	433.00
IUUC-Olo-080380	Oryza longistaminata	49.20	2.00e-120	427.00
IUUC-Ome-081925	Oryza meridionalis	49.20	2.00e-120	427.00
IUUC-Oni-082619	Oryza nivara	49.65	3.00e-122	433.00
IUUC-Opu-083684	Oryza punctata	49.20	1.00e-120	428.00
IUUC-Oru-084501	Oryza rufipogon	49.65	3.00e-122	433.00
IUUC-Osa-086251	Oryza sativa	49.65	3.00e-121	427.00
IUUC-Ola-087437	Oryzias latipes	44.96	0.00e+00	966.00
IUUC-Olu-087813	Ostreococcus lucimarinus	46.96	8.00e-112	395.00
IUUC-Oga-088903	Otolemur garnettii	43.89	0.00e+00	1681.00
IUUC-Oar-090210	Ovis aries	42.71	0.00e+00	1667.00
IUUC-Ptr-090502	Pan troglodytes	41.51	0.00e+00	1106.00
IUUC-Pan-092368	Papio anubis	40.06	0.00e+00	1110.00
IUUC-Pma-094246	Petromyzon marinus	41.72	2.00e-109	389.00
IUUC-Pno-094871	Phaeosphaeria nodorum	51.42	4.00e-132	466.00
IUUC-Ppa-095657	Physcomitrella patens	49.54	2.00e-119	424.00
IUUC-Pfo-096232	Poecilia formosa	44.37	0.00e+00	1456.00
IUUC-Pab-098583	Pongo abelii	45.25	0.00e+00	1679.00
IUUC-Pop-099468	Populus trichocarpa	49.65	2.00e-121	430.00
IUUC-Pca-100310	Procavia capensis	43.41	0.00e+00	767.00
IUUC-Ppe-101641	Prunus persica	50.12	1.00e-123	437.00
IUUC-Pva-102116	Pteropus vampyrus	43.87	0.00e+00	1696.00
IUUC-Pgr-103465	Puccinia graminis	41.01	6.00e-120	426.00
IUUC-Ptt-103813	Puccinia triticina	39.02	2.00e-106	381.00
IUUC-Pte-104018	Pyrenophora teres	51.18	2.00e-131	464.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	51.54	5.00e-131	462.00
IUUC-Rno-105889	Rattus norvegicus	50.38	0.00e+00	1247.00
IUUC-Sce-106449	Saccharomyces cerevisiae	50.92	1.00e-123	437.00
IUUC-Sha-106961	Sarcophilus harrisii	42.57	0.00e+00	1662.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	44.92	5.00e-126	446.00
IUUC-Spo-108024	Schizosaccharomyces pombe	51.18	7.00e-126	445.00
IUUC-Smo-109428	Selaginella moellendorffii	50.46	8.00e-126	445.00
IUUC-Sit-110598	Setaria italica	50.58	1.00e-123	438.00
IUUC-Sly-111706	Solanum lycopersicum	50.81	6.00e-125	442.00
IUUC-Stu-112894	Solanum tuberosum	30.94	6.00e-55	207.00
IUUC-Sar-113291	Sorex araneus	63.17	0.00e+00	860.00
IUUC-Sbi-114042	Sorghum bicolor	50.00	5.00e-122	432.00
IUUC-Sre-114958	Sporisorium reilianum	54.59	3.00e-135	474.00
IUUC-Ssc-115754	Sus scrofa	43.75	0.00e+00	1683.00
IUUC-Tru-118570	Takifugu rubripes	42.16	0.00e+00	1646.00
IUUC-Tsy-119159	Tarsius syrichta	54.13	0.00e+00	1006.00
IUUC-Tni-120836	Tetraodon nigroviridis	69.20	0.00e+00	769.00
IUUC-Tca-121479	Theobroma cacao	49.19	4.00e-121	429.00
IUUC-Tre-121909	Trichoderma reesei	44.07	9.00e-130	458.00
IUUC-Tvi-122370	Trichoderma virens	51.06	2.00e-129	457.00
IUUC-Tae-125214	Triticum aestivum	49.08	8.00e-121	427.00
IUUC-Tme-127172	Tuber melanosporum	44.01	1.00e-133	471.00
IUUC-Tbe-127506	Tupaia belangeri	35.55	4.00e-111	396.00
IUUC-Ttr-129253	Tursiops truncatus	62.08	0.00e+00	856.00
IUUC-Uma-129355	Ustilago maydis	46.83	6.00e-135	473.00
IUUC-Vda-129886	Verticillium dahliae	52.24	2.00e-130	460.00
IUUC-Vpa-130708	Vicugna pacos	44.83	0.00e+00	1562.00
IUUC-Vvi-131078	Vitis vinifera	49.65	1.00e-120	428.00
IUUC-Xtr-132123	Xenopus tropicalis	43.14	0.00e+00	1612.00
IUUC-Xma-133869	Xiphophorus maculatus	44.32	0.00e+00	1455.00
IUUC-Yli-134657	Yarrowia lipolytica	45.49	5.00e-131	462.00
IUUC-Zma-135570	Zea mays	49.43	2.00e-122	434.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence