iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072712

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01002947

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000014019.2	ENSOANT00000022109.2	ENSOANP00000022105.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-35	122.2	374	684

Active Site

Position(s)	Description	Evidence
658	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 5    lkkrlevefvgEe....gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            ++ +e++f++E+      d  G+++efl+ll+ +l+n+   lf+ s  + ++++ ++++      ++++++ +Gr+++++l++g + +
   Q: 374  PTETIEIRFSNEKemfgRGDVLGSKQEFLSLLMYHLENSP--LFEGS--SLKNISLDSEA-----LKENYYYEAGRMIAISLVHGGPSP 453
           567899*****98666544667****************98..67444..44454455544.....5799******************** PP
   S: 90   lplsksfyklllgk....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYv 174
            ++sk+++++l++     + ++ed+++vd  +++++  ik+      ++l + l+       + ++ ++  + g+ +     ++k+  v
   Q: 454  GFFSKTLFNCLVHGpenvEPTVEDVADVD--VAQTIIRIKSA-----TTL-ASLKTA-----VHDCFDHLNLAGCLRLVTLLSDKDVLV 529
           ************99444446666665554..66777777733.....443.444444.....456667744556666666689****** PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket...kykggytedspaiqwFwevleefssee 260
           k++++y++ ++++e +e+fr+G++ +  le+++l+ +e +++++++ e i+++ l++     ++ +   ++ +++ + +  l++++  e
   Q: 530  KDLLNYHVIKRVQEPLESFRQGLKALGVLEKMQLYPKEFCSIMCHKPERITAKCLSDLFtihMFSD--VKKARVVGYWMGYLQDVEGGE 616
           ******************************************************999773434444..567788888888999999988 PP
   S: 261  rkafLq....FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet 330
               L+    F+Tg+s++P+ Gfa  + ++ +++      ++P  n+C n+L LP  +++++++e++ +Ai++t
   Q: 617  SEVTLEdilfFATGTSSIPPVGFAMAP-SIEIMHM-----DYPLGNRCNNCLVLPITNTYKEFQENMDFAIRNT 684
           8766555555*************9887.7788887.....*******************************997 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSSGIWQRGK EEEGFYGFLI EDIRKEVNRA SKLKCTICKK NGASIGCVAR KCKRSYHYPC 60
GIQKECIFQF TGNFGSYCWE HRPVQKIPSS NCRGSSPCTI CLEFVEHLPR YNILRSPCCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAATTGTT TTCTAATTTT TTTTTTATTT CTAGTTGATG TCAAGTGGAA TTTGGCAGAG 60
AGGTAAAGAA GAGGAGGGAT TTTATGGTTT TTTAATAGAG GATATCAGAA AGGAAGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

oaa:100082219

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	68.01	0.00e+00	1008.00
IUUC-Apl-003763	Anas platyrhynchos	65.52	0.00e+00	945.00
IUUC-Aca-004328	Anolis carolinensis	61.37	0.00e+00	871.00
IUUC-Ame-011288	Astyanax mexicanus	38.76	1.00e-145	509.00
IUUC-Bta-012496	Bos taurus	66.04	0.00e+00	968.00
IUUC-Cja-019756	Callithrix jacchus	67.34	0.00e+00	987.00
IUUC-Cfa-020806	Canis familiaris	67.43	0.00e+00	998.00
IUUC-Cpo-022519	Cavia porcellus	65.18	0.00e+00	945.00
IUUC-Csa-023957	Chlorocebus sabaeus	68.58	0.00e+00	1012.00
IUUC-Cho-024375	Choloepus hoffmanni	61.41	0.00e+00	868.00
IUUC-Cin-025325	Ciona intestinalis	41.03	1.00e-51	196.00
IUUC-Csv-026262	Ciona savignyi	41.98	7.00e-57	213.00
IUUC-Dre-027829	Danio rerio	37.90	7.00e-143	500.00
IUUC-Dno-029362	Dasypus novemcinctus	67.34	0.00e+00	971.00
IUUC-Dor-030710	Dipodomys ordii	64.25	0.00e+00	945.00
IUUC-Dme-031692	Drosophila melanogaster	33.04	9.00e-35	140.00
IUUC-Ete-032282	Echinops telfairi	62.96	0.00e+00	737.00
IUUC-Eca-033963	Equus caballus	66.62	0.00e+00	989.00
IUUC-Eeu-035029	Erinaceus europaeus	66.71	0.00e+00	980.00
IUUC-Fca-036229	Felis catus	67.29	0.00e+00	1001.00
IUUC-Fal-037015	Ficedula albicollis	62.95	0.00e+00	885.00
IUUC-Gmo-039715	Gadus morhua	40.16	1.00e-76	279.00
IUUC-Gga-040298	Gallus gallus	63.52	0.00e+00	929.00
IUUC-Gac-041444	Gasterosteus aculeatus	36.28	2.00e-125	442.00
IUUC-Gma-044371	Glycine max	32.35	9.00e-10	57.80
IUUC-Ggo-045456	Gorilla gorilla	68.29	0.00e+00	1006.00
IUUC-Hsa-046297	Homo sapiens	68.72	0.00e+00	1015.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	63.82	0.00e+00	716.00
IUUC-Lch-050287	Latimeria chalumnae	67.57	8.00e-92	330.00
IUUC-Loc-052839	Lepisosteus oculatus	56.25	5.00e-19	85.50
IUUC-Laf-053581	Loxodonta africana	68.10	0.00e+00	1001.00
IUUC-Mcc-055615	Macaca mulatta	68.29	0.00e+00	1008.00
IUUC-Meu-056753	Macropus eugenii	52.85	6.00e-75	274.00
IUUC-Mtr-058201	Medicago truncatula	45.83	3.00e-10	59.70
IUUC-Mga-059902	Meleagris gallopavo	63.52	0.00e+00	932.00
IUUC-Mmr-061522	Microcebus murinus	68.49	0.00e+00	1001.00
IUUC-Mdo-063022	Monodelphis domestica	70.95	0.00e+00	933.00
IUUC-Mmu-063609	Mus musculus	63.97	0.00e+00	927.00
IUUC-Mpu-066656	Mustela putorius furo	66.71	0.00e+00	993.00
IUUC-Mlu-067011	Myotis lucifugus	66.43	0.00e+00	977.00
IUUC-Nle-069949	Nomascus leucogenys	68.44	0.00e+00	1008.00
IUUC-Opr-071224	Ochotona princeps	62.78	3.00e-101	362.00
IUUC-Ont-072174	Oreochromis niloticus	36.67	3.00e-129	454.00
IUUC-Ocu-073776	Oryctolagus cuniculus	67.86	0.00e+00	986.00
IUUC-Oba-075953	Oryza barthii	40.43	6.00e-09	55.50
IUUC-Ogl-076938	Oryza glaberrima	40.43	6.00e-09	55.50
IUUC-Oni-082364	Oryza nivara	40.43	6.00e-09	55.50
IUUC-Osa-085434	Oryza sativa	40.43	6.00e-09	55.10
IUUC-Ola-087247	Oryzias latipes	33.94	7.00e-113	400.00
IUUC-Oga-088094	Otolemur garnettii	66.09	0.00e+00	979.00
IUUC-Oar-090248	Ovis aries	65.99	0.00e+00	968.00
IUUC-Ptr-090634	Pan troglodytes	68.44	0.00e+00	1011.00
IUUC-Pan-092876	Papio anubis	68.44	0.00e+00	1009.00
IUUC-Psi-093580	Pelodiscus sinensis	67.29	0.00e+00	986.00
IUUC-Pma-094295	Petromyzon marinus	52.21	4.00e-71	260.00
IUUC-Pfo-096351	Poecilia formosa	36.91	3.00e-134	471.00
IUUC-Pab-097596	Pongo abelii	68.44	0.00e+00	1010.00
IUUC-Pca-100309	Procavia capensis	63.88	4.00e-140	491.00
IUUC-Pva-102526	Pteropus vampyrus	67.73	3.00e-179	621.00
IUUC-Rno-105432	Rattus norvegicus	64.98	0.00e+00	940.00
IUUC-Sha-107089	Sarcophilus harrisii	71.35	0.00e+00	1047.00
IUUC-Sar-113667	Sorex araneus	52.57	3.00e-169	588.00
IUUC-Ssc-116200	Sus scrofa	67.00	0.00e+00	992.00
IUUC-Tgu-116467	Taeniopygia guttata	62.52	0.00e+00	874.00
IUUC-Tru-117690	Takifugu rubripes	35.95	8.00e-138	483.00
IUUC-Tsy-119481	Tarsius syrichta	65.64	0.00e+00	655.00
IUUC-Tni-119669	Tetraodon nigroviridis	36.12	2.00e-122	432.00
IUUC-Tbe-127241	Tupaia belangeri	63.45	0.00e+00	891.00
IUUC-Ttr-129057	Tursiops truncatus	67.58	0.00e+00	758.00
IUUC-Vpa-130685	Vicugna pacos	66.86	0.00e+00	948.00
IUUC-Xtr-132555	Xenopus tropicalis	52.42	0.00e+00	708.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence