iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097882

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01048438

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000005001.2	ENSPPYT00000005920.1	ENSPPYP00000005702.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-13	49.8	472	505
UBD/Beta-Prp	1.50e-43	149.2	202	504

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v++++ +d+ +vsG+  g + vWD+rt+ +
   Q: 472  HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRTNQK 505
           7778999999669****************99865 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 202  ELEHVPDAVLRDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 286
           678889999998888..9***********************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 287  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVAVAAAGDLM-YLLKAEDS 374
           ***999999**********************************************************************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g  + +l +  + +++v++s +  +++vsg+ Dg +ri+dlrsg
   Q: 375  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGCRLLKLGNVLRDFTCVNLSdSPPNLMVSGNTDGRVRIHDLRSG 463
           **********************************************99*****************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+ +v++v++   +d+++v+g+e++ v +w++++n+
   Q: 464  NIALSLSAHQLRVSAVQM---DDWKIVSGGEEGLVSVWDYRTNQ 504
           ****************99...*******************9987 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MDDYSLDEFR RRWQEELAQA QAPKKRRRPE VAERRARRPE VGSGHGEQAS GDPTLAQGLL 60
EGAGRPPAAR ATRAEGQVTS RSRSPLAREG AGGEQLVDQL IRDLNEMNDV PFFDIQLPYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGGCTTCC GGTCGCGGCG GACACTTCCC TGGGAGGGAC TGTCCCGTGG CACCCGGTGG 60
AACCGAGGAG AACGTGGAGC GCCGGGAGCG GCGAATATGG ACGACTACAG CCTGGATGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	87.35	0.00e+00	921.00
IUUC-Apl-003239	Anas platyrhynchos	59.27	0.00e+00	667.00
IUUC-Aca-004756	Anolis carolinensis	57.39	2.00e-126	445.00
IUUC-Ame-011198	Astyanax mexicanus	41.69	2.00e-59	222.00
IUUC-Bta-012430	Bos taurus	55.83	3.00e-155	541.00
IUUC-Cja-019131	Callithrix jacchus	89.61	0.00e+00	1024.00
IUUC-Cfa-021022	Canis familiaris	77.96	0.00e+00	910.00
IUUC-Cpo-021898	Cavia porcellus	76.78	0.00e+00	895.00
IUUC-Csa-023452	Chlorocebus sabaeus	95.82	0.00e+00	1113.00
IUUC-Cho-024759	Choloepus hoffmanni	75.25	0.00e+00	823.00
IUUC-Dre-028123	Danio rerio	42.35	6.00e-141	494.00
IUUC-Dno-029045	Dasypus novemcinctus	86.65	0.00e+00	819.00
IUUC-Dor-030433	Dipodomys ordii	76.18	0.00e+00	747.00
IUUC-Ete-032465	Echinops telfairi	74.51	0.00e+00	726.00
IUUC-Eca-034134	Equus caballus	86.59	0.00e+00	887.00
IUUC-Eeu-035047	Erinaceus europaeus	76.73	0.00e+00	764.00
IUUC-Fca-036574	Felis catus	86.89	0.00e+00	870.00
IUUC-Fal-037665	Ficedula albicollis	58.88	2.00e-168	585.00
IUUC-Gmo-039137	Gadus morhua	40.73	2.00e-68	252.00
IUUC-Gga-040711	Gallus gallus	58.60	0.00e+00	653.00
IUUC-Gac-041675	Gasterosteus aculeatus	49.47	1.00e-48	185.00
IUUC-Ggo-045331	Gorilla gorilla	98.78	0.00e+00	1010.00
IUUC-Hsa-046240	Homo sapiens	97.99	0.00e+00	1118.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	87.60	0.00e+00	870.00
IUUC-Loc-052631	Lepisosteus oculatus	48.79	1.00e-162	566.00
IUUC-Laf-054127	Loxodonta africana	72.03	3.00e-55	206.00
IUUC-Mcc-055083	Macaca mulatta	96.66	0.00e+00	1098.00
IUUC-Mga-060113	Meleagris gallopavo	61.82	0.00e+00	638.00
IUUC-Mmr-061780	Microcebus murinus	85.14	0.00e+00	904.00
IUUC-Mdo-063066	Monodelphis domestica	60.84	0.00e+00	702.00
IUUC-Mmu-063524	Mus musculus	76.42	0.00e+00	823.00
IUUC-Mpu-066913	Mustela putorius furo	87.08	0.00e+00	902.00
IUUC-Mlu-067924	Myotis lucifugus	83.58	0.00e+00	910.00
IUUC-Nle-069558	Nomascus leucogenys	96.51	0.00e+00	1039.00
IUUC-Opr-070506	Ochotona princeps	79.60	0.00e+00	888.00
IUUC-Ont-071514	Oreochromis niloticus	45.00	5.00e-142	498.00
IUUC-Ocu-074477	Oryctolagus cuniculus	84.95	0.00e+00	853.00
IUUC-Ola-087416	Oryzias latipes	43.81	1.00e-144	506.00
IUUC-Oga-088643	Otolemur garnettii	80.37	0.00e+00	926.00
IUUC-Oar-090172	Ovis aries	85.86	0.00e+00	872.00
IUUC-Ptr-090870	Pan troglodytes	98.16	0.00e+00	1116.00
IUUC-Pan-092017	Papio anubis	95.32	0.00e+00	1108.00
IUUC-Psi-093794	Pelodiscus sinensis	62.83	0.00e+00	642.00
IUUC-Pfo-096192	Poecilia formosa	49.71	2.00e-143	503.00
IUUC-Pca-100902	Procavia capensis	81.92	1.00e-149	523.00
IUUC-Pva-103139	Pteropus vampyrus	82.97	0.00e+00	938.00
IUUC-Rno-105798	Rattus norvegicus	73.66	0.00e+00	846.00
IUUC-Sha-106576	Sarcophilus harrisii	64.55	0.00e+00	658.00
IUUC-Ssc-115923	Sus scrofa	75.84	0.00e+00	902.00
IUUC-Tgu-116667	Taeniopygia guttata	52.80	6.00e-107	380.00
IUUC-Tru-118323	Takifugu rubripes	43.81	2.00e-135	475.00
IUUC-Tsy-118818	Tarsius syrichta	69.29	3.00e-95	342.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.28	9.00e-135	473.00
IUUC-Tbe-127784	Tupaia belangeri	82.52	3.00e-95	342.00
IUUC-Ttr-128288	Tursiops truncatus	72.27	0.00e+00	795.00
IUUC-Vpa-130307	Vicugna pacos	77.68	0.00e+00	791.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence