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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018686
UUCD1 version UUC-CaE-00028
Ensembl Protein ID C01B7.6
UniProt Accession Q17551; RPM1_CAEEL
Genbank Protein ID CCD62087.1
Protein Name E3 ubiquitin-protein ligase rpm-1; Pam/highwire/rpm-1 protein; RING-type E3 ubiquitin transferase rpm-1; Regulator of presynaptic morphology protein 1; Synapse defective protein 3
Genbank Nucleotide ID FO080217
Gene Name rpm-1; syd-3; C01B7.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004457 C01B7.6 C01B7.6
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20592256; 19172179
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00014 22.6 3517 3567
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplv.lpCgHvfhadCl.....qkwpglknssskefrCPlC 45
           C iC+++      p++ l+CgH+fh++C+      +w + ++   ++ +CPlC
   Q: 3517 CVICFTERlgAA-PCIrLGCGHMFHFHCVrmileRRW-NGPRIVFRFMQCPLC 3567
           ****99665544.554499*********766789999.88888999999**** PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).
Protein Sequence
(Fasta)
MSFFLREIDG ERVCSTSTET SIPEDRKSAR RLRKLLYKCA ENTCKPDILR VPAHCGKLDK 60
EEEKSKTPLD QQQQINFHDI LNSKFVVGPP SPFALVAIAK SILARFGNPE EVSEKEDGSE 120
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Protein Fasta Sequence


>IUUC-Cel-018686|E3,RING|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
ATGTCGTTCT TCTTGCGAGA AATTGATGGT GAACGAGTGT GTTCCACGAG CACCGAAACG 60
TCGATTCCTG AAGATAGGAA AAGTGCACGA AGACTGAGAA AATTGCTATA CAAATGTGCC 120
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Nucleotide Fasta Sequence


>IUUC-Cel-018686|E3,RING|Caenorhabditis elegans
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Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51284--DOC
PS00626--RCC1_2
PS50012--RCC1_3
PS50119--ZF_BBOX
PS50089--ZF_RING_2
Pfam

PF03256--ANAPC10
PF08005--PHR
PF00415--RCC1
PF00643--zf-B_box
PF13639--zf-RING_2
SMART

SM01337--APC10
SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0030424--C:axon
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0036062--C:presynaptic periactive zone
GO:0045202--C:synapse
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0019903--F:protein phosphatase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0010171--P:body morphogenesis
GO:0033563--P:dorsal/ventral axon guidance
GO:0040011--P:locomotion
GO:1905869--P:negative regulation of 3'-UTR-mediated mRNA stabilization
GO:0030517--P:negative regulation of axon extension
GO:0048843--P:negative regulation of axon extension involved in axon guidance
GO:0048692--P:negative regulation of axon extension involved in regeneration
GO:0048681--P:negative regulation of axon regeneration
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043409--P:negative regulation of MAPK cascade
GO:1905490--P:negative regulation of sensory neuron axon guidance
GO:0018991--P:oviposition
GO:1905608--P:positive regulation of presynapse assembly
GO:0051965--P:positive regulation of synapse assembly
GO:1905868--P:regulation of 3'-UTR-mediated mRNA stabilization
GO:0048841--P:regulation of axon extension involved in axon guidance
GO:1905815--P:regulation of dorsal/ventral axon guidance
GO:1905812--P:regulation of motor neuron axon guidance
GO:1905606--P:regulation of presynapse assembly
GO:0031647--P:regulation of protein stability
GO:1905489--P:regulation of sensory neuron axon guidance
GO:0050807--P:regulation of synapse organization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG cel:CELE_C01B7.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001951 Ailuropoda melanoleuca 32.18 0.00e+00 641.00
IUUC-Apl-003625 Anas platyrhynchos 31.56 4.00e-166 579.00
IUUC-Aca-005207 Anolis carolinensis 32.06 9.00e-174 605.00
IUUC-Aor-010074 Aspergillus oryzae 35.97 9.00e-13 66.20
IUUC-Ame-010649 Astyanax mexicanus 32.33 1.00e-177 617.00
IUUC-Bta-012670 Bos taurus 32.31 0.00e+00 639.00
IUUC-Cja-019910 Callithrix jacchus 32.23 0.00e+00 639.00
IUUC-Cfa-020184 Canis familiaris 32.39 0.00e+00 641.00
IUUC-Cpo-021334 Cavia porcellus 41.94 1.00e-140 495.00
IUUC-Csa-023291 Chlorocebus sabaeus 32.31 0.00e+00 642.00
IUUC-Cho-024927 Choloepus hoffmanni 28.16 6.00e-50 193.00
IUUC-Cin-025345 Ciona intestinalis 32.65 1.00e-140 493.00
IUUC-Csv-026264 Ciona savignyi 29.73 4.00e-149 521.00
IUUC-Dre-028645 Danio rerio 32.56 1.00e-178 621.00
IUUC-Dno-029670 Dasypus novemcinctus 32.31 0.00e+00 640.00
IUUC-Dor-030993 Dipodomys ordii 30.40 2.00e-163 570.00
IUUC-Dme-031777 Drosophila melanogaster 38.91 7.00e-122 432.00
IUUC-Ete-032613 Echinops telfairi 45.24 4.00e-133 469.00
IUUC-Eca-034364 Equus caballus 32.14 0.00e+00 639.00
IUUC-Eeu-035200 Erinaceus europaeus 35.56 5.00e-142 499.00
IUUC-Fca-036054 Felis catus 32.31 0.00e+00 639.00
IUUC-Fal-036991 Ficedula albicollis 32.23 9.00e-176 611.00
IUUC-Gmo-038487 Gadus morhua 32.19 0.00e+00 652.00
IUUC-Gga-041035 Gallus gallus 32.47 3.00e-176 613.00
IUUC-Gac-041637 Gasterosteus aculeatus 31.78 4.00e-177 616.00
IUUC-Ggo-045091 Gorilla gorilla 27.30 2.00e-143 503.00
IUUC-Hsa-046977 Homo sapiens 32.31 0.00e+00 642.00
IUUC-Itr-048995 Ictidomys tridecemlineatus 26.92 1.00e-42 167.00
IUUC-Lch-050171 Latimeria chalumnae 39.36 3.00e-114 407.00
IUUC-Loc-052822 Lepisosteus oculatus 32.03 7.00e-178 619.00
IUUC-Laf-054065 Loxodonta africana 32.14 0.00e+00 640.00
IUUC-Mcc-054947 Macaca mulatta 32.31 0.00e+00 642.00
IUUC-Meu-056600 Macropus eugenii 45.87 5.00e-118 419.00
IUUC-Mga-059559 Meleagris gallopavo 32.14 2.00e-173 603.00
IUUC-Mmr-060973 Microcebus murinus 32.31 0.00e+00 641.00
IUUC-Mdo-061938 Monodelphis domestica 32.17 7.00e-176 612.00
IUUC-Mmu-063569 Mus musculus 32.14 0.00e+00 640.00
IUUC-Mpu-066457 Mustela putorius furo 31.53 4.00e-168 586.00
IUUC-Mlu-067165 Myotis lucifugus 27.19 7.00e-144 505.00
IUUC-Nle-069042 Nomascus leucogenys 32.06 3.00e-180 627.00
IUUC-Opr-070201 Ochotona princeps 27.72 3.00e-85 311.00
IUUC-Ont-072263 Oreochromis niloticus 32.37 1.00e-179 624.00
IUUC-Oan-073108 Ornithorhynchus anatinus 27.46 3.00e-138 486.00
IUUC-Ocu-074359 Oryctolagus cuniculus 32.23 0.00e+00 647.00
IUUC-Ola-087074 Oryzias latipes 28.15 4.00e-141 496.00
IUUC-Oga-088322 Otolemur garnettii 32.31 0.00e+00 640.00
IUUC-Oar-089244 Ovis aries 32.39 0.00e+00 642.00
IUUC-Ptr-091449 Pan troglodytes 32.31 0.00e+00 640.00
IUUC-Pan-091756 Papio anubis 32.23 0.00e+00 639.00
IUUC-Psi-093387 Pelodiscus sinensis 32.05 2.00e-171 597.00
IUUC-Pma-094327 Petromyzon marinus 26.49 2.00e-23 101.00
IUUC-Ppa-095276 Physcomitrella patens 38.10 6.00e-50 191.00
IUUC-Pfo-097372 Poecilia formosa 31.94 8.00e-177 615.00
IUUC-Pab-097572 Pongo abelii 32.39 0.00e+00 641.00
IUUC-Pca-101007 Procavia capensis 25.32 5.00e-127 449.00
IUUC-Pva-102217 Pteropus vampyrus 43.13 4.00e-137 483.00
IUUC-Rno-105422 Rattus norvegicus 32.14 0.00e+00 642.00
IUUC-Sha-107119 Sarcophilus harrisii 32.64 2.00e-175 609.00
IUUC-Smo-108712 Selaginella moellendorffii 37.25 1.00e-51 195.00
IUUC-Sar-113595 Sorex araneus 38.42 2.00e-120 427.00
IUUC-Ssc-115690 Sus scrofa 24.68 7.00e-152 532.00
IUUC-Tgu-116555 Taeniopygia guttata 32.23 5.00e-176 612.00
IUUC-Tru-117796 Takifugu rubripes 32.04 9.00e-180 625.00
IUUC-Tsy-118924 Tarsius syrichta 40.26 4.00e-132 466.00
IUUC-Tni-120759 Tetraodon nigroviridis 32.50 1.00e-180 627.00
IUUC-Tre-122202 Trichoderma reesei 52.94 4.00e-05 43.50
IUUC-Tvi-122439 Trichoderma virens 50.00 2.00e-04 41.20
IUUC-Ttr-128814 Tursiops truncatus 32.31 0.00e+00 640.00
IUUC-Uma-129630 Ustilago maydis 26.46 6.00e-09 54.70
IUUC-Vpa-130430 Vicugna pacos 29.58 8.00e-147 515.00
IUUC-Xtr-131898 Xenopus tropicalis 35.01 3.00e-62 232.00
Created Date 25-Jun-2017

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