iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.33	4.00e-153	538.00	IUUC-Hsa-046910

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance.

Protein Sequence
(Fasta)

MEPPMEQSGG EQEPGAVRLL DLPWEDVLLP HVLNWVPLRQ LLRLQRVSRA FRALVQLHLA 60
RLRRFDAAQV GPQIPRAALV RLLRDAEGLQ ELALAPCHEW LLDEDLVPVL ARNPQLRSVA 120

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Nucleotide Sequence
(Fasta)

CACCACTCAG AGGCGGCTAC CGGCCCGCAA CGAAGACCGA AAGCAGTCTT CGCTCGCCGC 60
TACTCCAGCC TCGGGCTTCA AGCCCTGTAG CTGAGAAGAC AACTAATGGT GCATCACTGG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

rno:309453

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002259	Ailuropoda melanoleuca	92.33	5.00e-143	500.00
IUUC-Apl-003471	Anas platyrhynchos	64.41	2.00e-79	288.00
IUUC-Aca-005211	Anolis carolinensis	61.74	2.00e-99	355.00
IUUC-Ame-011477	Astyanax mexicanus	56.15	2.00e-94	338.00
IUUC-Bta-013461	Bos taurus	95.33	1.00e-159	555.00
IUUC-Cja-019278	Callithrix jacchus	96.99	3.00e-146	510.00
IUUC-Cfa-020248	Canis familiaris	96.00	5.00e-151	526.00
IUUC-Cpo-021313	Cavia porcellus	91.67	1.00e-129	455.00
IUUC-Csa-023633	Chlorocebus sabaeus	95.00	2.00e-157	547.00
IUUC-Cin-025760	Ciona intestinalis	30.08	2.00e-36	145.00
IUUC-Csv-025866	Ciona savignyi	31.18	1.00e-39	156.00
IUUC-Dre-027366	Danio rerio	58.09	6.00e-99	353.00
IUUC-Dno-029700	Dasypus novemcinctus	95.33	6.00e-149	520.00
IUUC-Dor-031069	Dipodomys ordii	93.29	2.00e-153	535.00
IUUC-Dme-031701	Drosophila melanogaster	31.52	2.00e-26	112.00
IUUC-Ete-032998	Echinops telfairi	86.62	4.00e-131	461.00
IUUC-Eca-034140	Equus caballus	96.67	6.00e-146	509.00
IUUC-Fca-035431	Felis catus	96.67	2.00e-151	528.00
IUUC-Fal-036960	Ficedula albicollis	64.89	4.00e-101	361.00
IUUC-Gmo-039411	Gadus morhua	57.09	3.00e-94	337.00
IUUC-Gga-040351	Gallus gallus	65.25	7.00e-100	356.00
IUUC-Gac-041972	Gasterosteus aculeatus	57.80	1.00e-86	312.00
IUUC-Ggo-044538	Gorilla gorilla	95.00	5.00e-144	503.00
IUUC-Hsa-046910	Homo sapiens	95.33	2.00e-144	504.00
IUUC-Itr-048011	Ictidomys tridecemlineatus	96.32	1.00e-149	521.00
IUUC-Lch-049710	Latimeria chalumnae	55.96	6.00e-99	353.00
IUUC-Loc-052288	Lepisosteus oculatus	58.45	3.00e-98	351.00
IUUC-Laf-053590	Loxodonta africana	87.76	4.00e-133	467.00
IUUC-Meu-056548	Macropus eugenii	79.86	3.00e-122	431.00
IUUC-Mga-059794	Meleagris gallopavo	64.18	2.00e-98	352.00
IUUC-Mmr-060829	Microcebus murinus	95.33	7.00e-149	519.00
IUUC-Mdo-062207	Monodelphis domestica	80.74	3.00e-132	464.00
IUUC-Mmu-063353	Mus musculus	99.00	1.00e-156	545.00
IUUC-Mpu-065841	Mustela putorius furo	96.33	1.00e-150	525.00
IUUC-Mlu-068035	Myotis lucifugus	92.73	4.00e-139	486.00
IUUC-Nle-069269	Nomascus leucogenys	96.33	1.00e-145	508.00
IUUC-Opr-070289	Ochotona princeps	88.56	6.00e-108	383.00
IUUC-Ont-072581	Oreochromis niloticus	55.17	6.00e-93	333.00
IUUC-Oan-073529	Ornithorhynchus anatinus	66.52	3.00e-77	280.00
IUUC-Ocu-074827	Oryctolagus cuniculus	95.33	5.00e-154	536.00
IUUC-Ola-087306	Oryzias latipes	55.70	1.00e-96	345.00
IUUC-Oga-088596	Otolemur garnettii	95.56	8.00e-136	476.00
IUUC-Oar-089473	Ovis aries	75.12	3.00e-83	300.00
IUUC-Ptr-091197	Pan troglodytes	95.33	1.00e-144	505.00
IUUC-Pan-092908	Papio anubis	95.67	3.00e-154	537.00
IUUC-Psi-093318	Pelodiscus sinensis	60.75	5.00e-69	254.00
IUUC-Pfo-097479	Poecilia formosa	56.42	2.00e-96	344.00
IUUC-Pab-097744	Pongo abelii	95.33	2.00e-144	504.00
IUUC-Pca-100930	Procavia capensis	91.67	5.00e-139	487.00
IUUC-Pva-102763	Pteropus vampyrus	85.71	4.00e-55	208.00
IUUC-Tgu-117097	Taeniopygia guttata	65.60	5.00e-103	367.00
IUUC-Tru-118057	Takifugu rubripes	56.55	1.00e-94	338.00
IUUC-Tni-120693	Tetraodon nigroviridis	56.55	2.00e-93	335.00
IUUC-Tbe-127992	Tupaia belangeri	97.38	5.00e-104	370.00
IUUC-Xtr-132283	Xenopus tropicalis	56.85	7.00e-99	353.00
IUUC-Xma-134238	Xiphophorus maculatus	56.84	4.00e-95	340.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence