iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027938

Ensembl Protein ID

ENSDARP00000054866.4

UniProt Accession

Q6PBN5; Q6P0U2; AUP1_DANRE

Genbank Protein ID

AAH65447.1; AAH59643.1

Protein Name

Ancient ubiquitous protein 1

Genbank Nucleotide ID

BC065447; BC059643

Gene Name

aup1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000092609.3	ENSDART00000054867.5	ENSDARP00000054866.4
ENSDARG00000092609.3	ENSDART00000140260.2	ENSDARP00000124945.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.30e-09	38.8	308	344

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 5    aleqLkeiFPnldysviqvvLeantgsleaavnnLLeg 42
           +++q+ke++P++++svi+++L  +t++++++++nLLe 
   Q: 308  LAQQVKEVLPDVPVSVITRDL-LQTNCVDTTITNLLER 344
           689******************.**************95 PP

Organism

Danio rerio

Functional Description
(View)

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Protein Sequence
(Fasta)

METRGIEQMF DFQRLPNDRF ILLLLLLYAP VGFCLMLLRI FIGVHVFLVS CALPDSIVRR 60
FIVRIMCSVL GLHVQQNSPR LRDKTTRLYV CNHVTHFDHN IINLLTSCNT PLLEGPVGFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTTTGCG CTTCATCTAG AAACATCAGC CGCGTCTCAA CATGGCGAAA AACAGCACAG 60
GCTAATAGCG GCTAGCGTTT CTCCCCCCTC ACCTTCCGTT TAATCCCGAG GAATAGTATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

SMART

SM00546--CUE

Gene Ontology

GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

dre:324654

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000658	Aegilops tauschii	35.00	2.70e-01	28.50
IUUC-Aml-002330	Ailuropoda melanoleuca	50.55	1.00e-90	327.00
IUUC-Apl-003946	Anas platyrhynchos	58.63	5.00e-112	397.00
IUUC-Aca-004676	Anolis carolinensis	50.00	6.00e-24	103.00
IUUC-Bta-012397	Bos taurus	54.33	1.00e-115	409.00
IUUC-Bdi-014890	Brachypodium distachyon	32.69	2.00e-07	50.40
IUUC-Cel-018644	Caenorhabditis elegans	32.94	2.00e-42	166.00
IUUC-Cja-018775	Callithrix jacchus	48.71	2.00e-70	259.00
IUUC-Cfa-020710	Canis familiaris	53.62	3.00e-108	385.00
IUUC-Cpo-022111	Cavia porcellus	53.35	2.00e-116	412.00
IUUC-Csa-023411	Chlorocebus sabaeus	53.38	2.00e-113	402.00
IUUC-Cin-025458	Ciona intestinalis	40.54	6.00e-18	82.00
IUUC-Dno-028873	Dasypus novemcinctus	53.70	7.00e-114	404.00
IUUC-Dor-030537	Dipodomys ordii	47.67	7.00e-98	350.00
IUUC-Dse-031401	Dothistroma septosporum	27.27	6.40e-02	32.70
IUUC-Ete-032422	Echinops telfairi	56.14	3.00e-29	123.00
IUUC-Eca-033757	Equus caballus	53.73	2.00e-114	405.00
IUUC-Eeu-034556	Erinaceus europaeus	48.76	1.00e-78	286.00
IUUC-Fca-035438	Felis catus	53.62	2.00e-114	405.00
IUUC-Fal-036911	Ficedula albicollis	56.15	1.00e-109	390.00
IUUC-Gmo-039147	Gadus morhua	64.45	7.00e-155	540.00
IUUC-Gga-041239	Gallus gallus	59.76	3.00e-127	448.00
IUUC-Gac-041814	Gasterosteus aculeatus	66.27	4.00e-164	570.00
IUUC-Ggo-044745	Gorilla gorilla	49.35	3.00e-71	262.00
IUUC-Hsa-046167	Homo sapiens	53.62	3.00e-114	405.00
IUUC-Itr-048661	Ictidomys tridecemlineatus	52.51	1.00e-105	376.00
IUUC-Lch-050576	Latimeria chalumnae	59.20	5.00e-127	447.00
IUUC-Lpe-051312	Leersia perrieri	29.13	5.00e-03	36.20
IUUC-Loc-052028	Lepisosteus oculatus	66.12	4.00e-158	550.00
IUUC-Laf-053886	Loxodonta africana	53.64	2.00e-99	355.00
IUUC-Mcc-055399	Macaca mulatta	50.72	8.00e-100	357.00
IUUC-Meu-056355	Macropus eugenii	45.54	1.00e-44	174.00
IUUC-Mga-060065	Meleagris gallopavo	58.64	8.00e-109	386.00
IUUC-Mmu-064080	Mus musculus	50.56	2.00e-86	313.00
IUUC-Mpu-066233	Mustela putorius furo	53.86	2.00e-114	405.00
IUUC-Mlu-067489	Myotis lucifugus	52.90	6.00e-113	400.00
IUUC-Nle-070040	Nomascus leucogenys	49.03	1.00e-70	260.00
IUUC-Ont-071616	Oreochromis niloticus	66.34	7.00e-159	553.00
IUUC-Ocu-074618	Oryctolagus cuniculus	54.00	1.00e-114	406.00
IUUC-Ogl-077799	Oryza glaberrima	30.48	1.20e-02	35.00
IUUC-Ome-081941	Oryza meridionalis	38.46	3.00e-04	40.40
IUUC-Opu-083500	Oryza punctata	38.46	1.00e-04	41.60
IUUC-Ola-086583	Oryzias latipes	53.32	2.00e-136	479.00
IUUC-Oga-089100	Otolemur garnettii	52.98	2.00e-112	399.00
IUUC-Oar-089813	Ovis aries	54.33	6.00e-116	410.00
IUUC-Ptr-091436	Pan troglodytes	53.62	3.00e-114	405.00
IUUC-Pan-092755	Papio anubis	53.62	2.00e-113	402.00
IUUC-Psi-093736	Pelodiscus sinensis	69.62	2.00e-62	231.00
IUUC-Pma-094429	Petromyzon marinus	53.05	8.00e-104	370.00
IUUC-Pfo-097015	Poecilia formosa	67.46	3.00e-159	554.00
IUUC-Pab-098382	Pongo abelii	53.38	1.00e-113	402.00
IUUC-Pca-100900	Procavia capensis	46.41	2.00e-40	160.00
IUUC-Pva-103248	Pteropus vampyrus	46.53	1.00e-63	237.00
IUUC-Rno-105755	Rattus norvegicus	50.85	2.00e-89	322.00
IUUC-Sha-107434	Sarcophilus harrisii	49.66	2.00e-60	226.00
IUUC-Stu-112774	Solanum tuberosum	26.48	2.00e-07	50.80
IUUC-Sar-113104	Sorex araneus	44.30	4.00e-58	218.00
IUUC-Ssc-116047	Sus scrofa	51.54	4.00e-88	318.00
IUUC-Tgu-117436	Taeniopygia guttata	57.85	2.00e-123	435.00
IUUC-Tru-118227	Takifugu rubripes	63.90	5.00e-159	553.00
IUUC-Tni-120873	Tetraodon nigroviridis	63.74	5.00e-158	550.00
IUUC-Ttr-128895	Tursiops truncatus	42.56	2.00e-86	312.00
IUUC-Xtr-131917	Xenopus tropicalis	55.08	6.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence