iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046160

Ensembl Protein ID

ENSP00000268607.5

UniProt Accession

Q9GZQ8; Q6NW02; MLP3B_HUMAN

Genbank Protein ID

AAG23182.1; AAG09686.1; AAM10499.1; BAB15169.1; AAH18634.1; AAH41874.1; AAH67797.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta

Genbank Nucleotide ID

AF303888; AF183417; AF087871; AK025556; BC018634; BC041874; BC067797

Gene Name

MAP1LC3B; MAP1ALC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140941.12	ENST00000268607.9	ENSP00000268607.5
ENSG00000140941.12	ENST00000570189.5	ENSP00000457141.1
ENSG00000140941.12	ENST00000565788.1	ENSP00000457225.1
ENSG00000140941.12	ENST00000564844.1	ENSP00000454293.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/ATG8	ATG8	23721406

Classification

Family	E-value	Score	Start	End
ULD/UBL/ATG8	2.30e-48	164.4	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeekded 90
           +r+e+v+ ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++l+kiir+rlql+a++a+fllvn  s+vsvs++++e+ye+ekded
   Q: 15   QRVEDVRLIREQHPTKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGhSMVSVSTPISEVYESEKDED 106
           699*************************99****************************************99******************** PP
   S: 91   gflyvayaseetfG 104
           gfly++yas+etfG
   Q: 107  GFLYMVYASQETFG 120
           *************9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Protein Sequence
(Fasta)

MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SEKDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGATGCCG AGTGCAAAAC GTTAGACTGC CCCGTGTGAG GCTCGAACTC ACGACCTTCA 60
GATTATGAGA CTGACGCGCT GCCTACTGCG CTAACGAGGC TGCTCGGCGA CCACTTCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005622--C:intracellular
GO:0005874--C:microtubule
GO:0005739--C:mitochondrion
GO:0031090--C:organelle membrane
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0000422--P:mitophagy

KEGG

hsa:81631

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001523	Ailuropoda melanoleuca	98.41	3.00e-68	249.00
IUUC-Apl-004007	Anas platyrhynchos	89.92	4.00e-59	219.00
IUUC-Aca-004678	Anolis carolinensis	91.74	4.00e-62	229.00
IUUC-Bta-013149	Bos taurus	99.20	7.00e-70	255.00
IUUC-Cja-019405	Callithrix jacchus	100.00	3.00e-70	256.00
IUUC-Cfa-020120	Canis familiaris	98.41	5.00e-68	249.00
IUUC-Cpo-021922	Cavia porcellus	100.00	1.00e-67	248.00
IUUC-Csa-023961	Chlorocebus sabaeus	100.00	3.00e-70	256.00
IUUC-Cho-024909	Choloepus hoffmanni	89.91	6.00e-53	198.00
IUUC-Cin-025249	Ciona intestinalis	75.83	3.00e-53	199.00
IUUC-Dre-028586	Danio rerio	93.44	9.00e-65	238.00
IUUC-Dno-029506	Dasypus novemcinctus	99.20	5.00e-69	252.00
IUUC-Dor-030793	Dipodomys ordii	96.80	5.00e-68	249.00
IUUC-Ete-032996	Echinops telfairi	98.15	2.00e-59	219.00
IUUC-Eca-034195	Equus caballus	99.20	1.00e-69	254.00
IUUC-Fca-035717	Felis catus	96.46	4.00e-59	219.00
IUUC-Fal-037169	Ficedula albicollis	87.10	2.00e-60	224.00
IUUC-Gmo-038732	Gadus morhua	89.17	2.00e-62	230.00
IUUC-Gga-041131	Gallus gallus	95.20	2.00e-67	246.00
IUUC-Gac-041441	Gasterosteus aculeatus	88.80	9.00e-64	234.00
IUUC-Ggo-044417	Gorilla gorilla	100.00	7.00e-62	228.00
IUUC-Itr-048601	Ictidomys tridecemlineatus	97.22	1.00e-57	214.00
IUUC-Lch-050631	Latimeria chalumnae	95.90	1.00e-66	244.00
IUUC-Loc-052865	Lepisosteus oculatus	96.67	6.00e-66	242.00
IUUC-Laf-053756	Loxodonta africana	97.62	6.00e-68	248.00
IUUC-Mcc-054698	Macaca mulatta	100.00	3.00e-70	256.00
IUUC-Meu-056702	Macropus eugenii	86.40	1.00e-58	218.00
IUUC-Mga-059558	Meleagris gallopavo	87.20	5.00e-61	225.00
IUUC-Mdo-062675	Monodelphis domestica	98.40	8.00e-69	251.00
IUUC-Mmu-063150	Mus musculus	95.20	9.00e-68	248.00
IUUC-Mpu-066210	Mustela putorius furo	90.40	7.00e-63	232.00
IUUC-Mlu-067216	Myotis lucifugus	94.12	2.00e-61	227.00
IUUC-Nle-069962	Nomascus leucogenys	100.00	3.00e-70	256.00
IUUC-Opr-070758	Ochotona princeps	95.45	1.00e-58	217.00
IUUC-Ont-072582	Oreochromis niloticus	94.17	3.00e-64	236.00
IUUC-Oan-072816	Ornithorhynchus anatinus	91.87	7.00e-62	228.00
IUUC-Ocu-073918	Oryctolagus cuniculus	88.62	6.00e-59	218.00
IUUC-Oga-088260	Otolemur garnettii	97.60	5.00e-69	252.00
IUUC-Oar-090154	Ovis aries	99.20	7.00e-70	255.00
IUUC-Ptr-091009	Pan troglodytes	100.00	3.00e-70	256.00
IUUC-Pan-091694	Papio anubis	100.00	3.00e-70	256.00
IUUC-Psi-093327	Pelodiscus sinensis	94.64	5.00e-59	218.00
IUUC-Pma-094489	Petromyzon marinus	83.33	3.00e-57	213.00
IUUC-Pfo-096338	Poecilia formosa	90.83	1.00e-61	228.00
IUUC-Pab-098381	Pongo abelii	100.00	2.00e-69	253.00
IUUC-Pca-100621	Procavia capensis	97.60	6.00e-69	252.00
IUUC-Pva-102563	Pteropus vampyrus	99.20	1.00e-69	254.00
IUUC-Rno-106063	Rattus norvegicus	96.00	2.00e-68	250.00
IUUC-Sha-107561	Sarcophilus harrisii	98.21	9.00e-61	225.00
IUUC-Sar-113048	Sorex araneus	97.73	5.00e-47	178.00
IUUC-Ssc-116253	Sus scrofa	99.20	7.00e-70	255.00
IUUC-Tgu-117120	Taeniopygia guttata	94.40	1.00e-66	244.00
IUUC-Tru-118140	Takifugu rubripes	92.50	2.00e-63	233.00
IUUC-Tsy-118793	Tarsius syrichta	99.10	4.00e-61	225.00
IUUC-Tbe-127594	Tupaia belangeri	97.30	9.00e-60	221.00
IUUC-Ttr-128932	Tursiops truncatus	99.20	7.00e-70	255.00
IUUC-Vpa-130747	Vicugna pacos	98.20	7.00e-61	224.00
IUUC-Xtr-132757	Xenopus tropicalis	94.35	3.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence