iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000228001.8	ENST00000429471.6	ENSP00000393674.2
ENSG00000228001.8	ENST00000437563.5	ENSP00000416950.1

Annotation

mRNA Expression
ArrayExpress
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.90e-09	38.2	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC+e++k+  ++++CgH+f++ Cl q++   k s+s+ f CPlCr
   Q: 14   CPICQESLKE-AVSTNCGHLFCRVCLtQHV--EKASASGVFCCPLCR 57
           ********99.999************8888..8889**********8 PP

Organism

Homo sapiens

Functional Description
(View)

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.

Protein Sequence
(Fasta)

MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV FCCPLCRKPC 60
SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM SHHELTIENA LSHYKERLNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAAGAACCA CTCATCTGCT GGCCATCTCT CCAGGTCTGG AGCCAGAGAA GATGATCTGA 60
AATTGTAGCA GGAGAAATTG AGGTAGGATA CTAAGAAAGC TTTTCAGGAG TGGGGCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0008270--F:zinc ion binding
GO:0030308--P:negative regulation of cell growth
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:1901223--P:negative regulation of NIK/NF-kappaB signaling
GO:0042177--P:negative regulation of protein catabolic process
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0045116--P:protein neddylation

KEGG

hsa:135644

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001427	Ailuropoda melanoleuca	60.82	5.00e-61	227.00
IUUC-Csa-023101	Chlorocebus sabaeus	83.86	2.00e-118	418.00
IUUC-Dor-030164	Dipodomys ordii	70.48	5.00e-78	283.00
IUUC-Dse-031337	Dothistroma septosporum	37.04	5.00e-09	55.50
IUUC-Ete-032446	Echinops telfairi	51.23	3.00e-54	204.00
IUUC-Eca-034042	Equus caballus	75.74	3.00e-93	334.00
IUUC-Eeu-034444	Erinaceus europaeus	59.74	4.00e-67	247.00
IUUC-Ggo-044410	Gorilla gorilla	99.22	4.00e-136	476.00
IUUC-Itr-048126	Ictidomys tridecemlineatus	61.60	1.00e-76	279.00
IUUC-Laf-054019	Loxodonta africana	58.37	2.00e-61	228.00
IUUC-Mcc-054616	Macaca mulatta	96.46	3.00e-142	497.00
IUUC-Nle-069843	Nomascus leucogenys	95.71	2.00e-60	224.00
IUUC-Ocu-073939	Oryctolagus cuniculus	70.87	2.00e-83	302.00
IUUC-Oga-088040	Otolemur garnettii	77.95	4.00e-103	367.00
IUUC-Ptr-091240	Pan troglodytes	88.37	1.00e-115	408.00
IUUC-Pan-092095	Papio anubis	96.46	2.00e-126	444.00
IUUC-Pab-098406	Pongo abelii	97.29	5.00e-134	469.00
IUUC-Pca-101043	Procavia capensis	62.88	2.00e-76	278.00
IUUC-Pva-102651	Pteropus vampyrus	70.93	1.00e-102	365.00
IUUC-Smo-109224	Selaginella moellendorffii	46.81	4.00e-06	46.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence